BAMBI_MOUSE
ID BAMBI_MOUSE Reviewed; 260 AA.
AC Q9D0L6; Q3TP85; Q91XS6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=BMP and activin membrane-bound inhibitor homolog;
DE AltName: Full=Putative transmembrane protein NMA;
DE Flags: Precursor;
GN Name=Bambi; Synonyms=Nma;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=Swiss Webster; TISSUE=Tooth;
RX PubMed=11706948; DOI=10.1177/00220345010800100701;
RA Knight C., Simmons D., Gu T.T., Gluhak-Heinrich J., Pavlin D.,
RA Zeichner-David M., MacDougall M.;
RT "Cloning, characterization, and tissue expression pattern of mouse
RT Nma/BAMBI during odontogenesis.";
RL J. Dent. Res. 80:1895-1902(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negatively regulates TGF-beta signaling. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels during odontogenesis.
CC {ECO:0000269|PubMed:11706948}.
CC -!- SIMILARITY: Belongs to the BAMBI family. {ECO:0000305}.
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DR EMBL; AF153440; AAK60413.1; -; mRNA.
DR EMBL; AK011305; BAB27531.1; -; mRNA.
DR EMBL; AK045192; BAC32256.1; -; mRNA.
DR EMBL; AK164632; BAE37852.1; -; mRNA.
DR EMBL; BC019378; AAH19378.1; -; mRNA.
DR CCDS; CCDS29034.1; -.
DR RefSeq; NP_080781.1; NM_026505.2.
DR AlphaFoldDB; Q9D0L6; -.
DR BioGRID; 212594; 2.
DR IntAct; Q9D0L6; 1.
DR STRING; 10090.ENSMUSP00000025075; -.
DR GlyGen; Q9D0L6; 1 site.
DR PhosphoSitePlus; Q9D0L6; -.
DR PaxDb; Q9D0L6; -.
DR PRIDE; Q9D0L6; -.
DR ProteomicsDB; 277177; -.
DR ABCD; Q9D0L6; 6 sequenced antibodies.
DR Antibodypedia; 26191; 282 antibodies from 31 providers.
DR DNASU; 68010; -.
DR Ensembl; ENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232.
DR GeneID; 68010; -.
DR KEGG; mmu:68010; -.
DR UCSC; uc008dyc.1; mouse.
DR CTD; 25805; -.
DR MGI; MGI:1915260; Bambi.
DR VEuPathDB; HostDB:ENSMUSG00000024232; -.
DR eggNOG; ENOG502QXJJ; Eukaryota.
DR GeneTree; ENSGT00940000154101; -.
DR HOGENOM; CLU_093515_0_0_1; -.
DR InParanoid; Q9D0L6; -.
DR OMA; TMSTLEC; -.
DR OrthoDB; 1225762at2759; -.
DR PhylomeDB; Q9D0L6; -.
DR TreeFam; TF333466; -.
DR Reactome; R-MMU-2173788; Downregulation of TGF-beta receptor signaling.
DR BioGRID-ORCS; 68010; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Bambi; mouse.
DR PRO; PR:Q9D0L6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9D0L6; protein.
DR Bgee; ENSMUSG00000024232; Expressed in calcareous tooth and 283 other tissues.
DR Genevisible; Q9D0L6; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005109; F:frizzled binding; ISO:MGI.
DR GO; GO:0016477; P:cell migration; ISO:MGI.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:MGI.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:MGI.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:MGI.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0008360; P:regulation of cell shape; ISO:MGI.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISA:MGI.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR009345; BAMBI.
DR InterPro; IPR045806; BAMBI_C.
DR InterPro; IPR045807; BAMBI_N.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR15505:SF1; PTHR15505:SF1; 2.
DR Pfam; PF06211; BAMBI; 1.
DR Pfam; PF19337; BAMBI_C; 1.
DR PIRSF; PIRSF037456; BAMBI; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..260
FT /note="BMP and activin membrane-bound inhibitor homolog"
FT /id="PRO_0000020780"
FT TOPO_DOM 27..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 26
FT /note="G -> E (in Ref. 1; AAK60413)"
FT /evidence="ECO:0000305"
FT CONFLICT 116..118
FT /note="SKS -> PRG (in Ref. 1; AAK60413)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="K -> N (in Ref. 1; AAK60413)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="N -> I (in Ref. 1; AAK60413)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29198 MW; 3C27915AFA112693 CRC64;
MDRHSSYFFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN
TNSPLTHGCL DSLASTADIC RAKQAQNHSG PAMPTLECCH EDMCNYRGLH DVLSPSKSEA
SGQGNRYQHD SSRNLITKMQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN
KRLQDERQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQAELSNE
KILSLVHWGM YSGHGKLEFI
