ID   BAMBI_RAT               Reviewed;         260 AA.
AC   Q91XN4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=BMP and activin membrane-bound inhibitor homolog;
DE   AltName: Full=Kinase-deficient TGFbeta superfamily receptor subunit;
DE   Flags: Precursor;
GN   Name=Bambi;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=12933693; DOI=10.1210/en.2002-0124;
RA   Loveland K.L., Bakker M., Meehan T., Christy E., von Schonfeldt V.,
RA   Drummond A., de Kretser D.;
RT   "Expression of Bambi is widespread in juvenile and adult rat tissues and is
RT   regulated in male germ cells.";
RL   Endocrinology 144:4180-4186(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Negatively regulates TGF-beta signaling.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in granulosa and thecal cells of adult
CC       ovaries and in spermatogonia, spermatocytes, round spermatids, and
CC       Sertoli cells of adult testes. {ECO:0000269|PubMed:12933693}.
CC   -!- SIMILARITY: Belongs to the BAMBI family. {ECO:0000305}.
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DR   EMBL; AF387513; AAK67353.1; -; mRNA.
DR   EMBL; BC070516; AAH70516.1; -; mRNA.
DR   RefSeq; NP_620782.1; NM_139082.3.
DR   AlphaFoldDB; Q91XN4; -.
DR   STRING; 10116.ENSRNOP00000021801; -.
DR   GlyGen; Q91XN4; 1 site.
DR   PaxDb; Q91XN4; -.
DR   PRIDE; Q91XN4; -.
DR   Ensembl; ENSRNOT00000021801; ENSRNOP00000021801; ENSRNOG00000016066.
DR   GeneID; 83837; -.
DR   KEGG; rno:83837; -.
DR   UCSC; RGD:621831; rat.
DR   CTD; 25805; -.
DR   RGD; 621831; Bambi.
DR   eggNOG; ENOG502QXJJ; Eukaryota.
DR   GeneTree; ENSGT00940000154101; -.
DR   HOGENOM; CLU_093515_0_0_1; -.
DR   InParanoid; Q91XN4; -.
DR   OMA; TMSTLEC; -.
DR   OrthoDB; 1225762at2759; -.
DR   PhylomeDB; Q91XN4; -.
DR   TreeFam; TF333466; -.
DR   Reactome; R-RNO-2173788; Downregulation of TGF-beta receptor signaling.
DR   PRO; PR:Q91XN4; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000016066; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q91XN4; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0005109; F:frizzled binding; ISO:RGD.
DR   GO; GO:0016477; P:cell migration; ISO:RGD.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:RGD.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:RGD.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:RGD.
DR   GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEP:RGD.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR009345; BAMBI.
DR   InterPro; IPR045806; BAMBI_C.
DR   InterPro; IPR045807; BAMBI_N.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR15505:SF1; PTHR15505:SF1; 2.
DR   Pfam; PF06211; BAMBI; 1.
DR   Pfam; PF19337; BAMBI_C; 1.
DR   PIRSF; PIRSF037456; BAMBI; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..260
FT                   /note="BMP and activin membrane-bound inhibitor homolog"
FT                   /id="PRO_0000020781"
FT   TOPO_DOM        27..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29143 MW;  E33CC1729DE260A1 CRC64;
     MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN
     TNSPLTHGCL DSLASTADIC RAKQAQNHSG PTMPTLECCH EDMCNYRGLH DVLSPPKSEA
     SGQGNRYQHD SSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN
     KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQADLSNE
     KILSLVHWGM YSGHGKLEFV