RS4_STAA8
ID RS4_STAA8 Reviewed; 200 AA.
AC Q2FXK6;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=30S ribosomal protein S4 {ECO:0000255|HAMAP-Rule:MF_01306};
GN Name=rpsD {ECO:0000255|HAMAP-Rule:MF_01306};
GN OrderedLocusNames=SAOUHSC_01829;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- FUNCTION: With S5 and S12 plays an important role in translational
CC accuracy. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts protein S5. The
CC interaction surface between S4 and S5 is involved in control of
CC translational fidelity. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
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DR EMBL; CP000253; ABD30897.1; -; Genomic_DNA.
DR RefSeq; WP_000090512.1; NZ_LS483365.1.
DR RefSeq; YP_500334.1; NC_007795.1.
DR PDB; 5LI0; EM; 3.80 A; d=2-200.
DR PDB; 5ND8; EM; 3.70 A; d=1-200.
DR PDB; 5ND9; EM; 3.70 A; d=1-200.
DR PDB; 5TCU; EM; 3.90 A; SC=3-200.
DR PDB; 6YEF; EM; 3.20 A; d=1-200.
DR PDB; 7BGD; EM; 3.20 A; d=1-200.
DR PDB; 7KWG; EM; 3.75 A; d=1-200.
DR PDB; 7NHL; EM; 3.10 A; e=1-200.
DR PDB; 7NHM; EM; 3.10 A; e=1-200.
DR PDBsum; 5LI0; -.
DR PDBsum; 5ND8; -.
DR PDBsum; 5ND9; -.
DR PDBsum; 5TCU; -.
DR PDBsum; 6YEF; -.
DR PDBsum; 7BGD; -.
DR PDBsum; 7KWG; -.
DR PDBsum; 7NHL; -.
DR PDBsum; 7NHM; -.
DR AlphaFoldDB; Q2FXK6; -.
DR SMR; Q2FXK6; -.
DR IntAct; Q2FXK6; 2.
DR STRING; 1280.SAXN108_1748; -.
DR EnsemblBacteria; ABD30897; ABD30897; SAOUHSC_01829.
DR GeneID; 3921779; -.
DR KEGG; sao:SAOUHSC_01829; -.
DR PATRIC; fig|93061.5.peg.1668; -.
DR eggNOG; COG0522; Bacteria.
DR HOGENOM; CLU_092403_0_1_9; -.
DR OMA; NVVFRMG; -.
DR PRO; PR:Q2FXK6; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0045903; P:positive regulation of translational fidelity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_01306_B; Ribosomal_S4_B; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR005709; Ribosomal_S4_bac-type.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR PANTHER; PTHR11831:SF4; PTHR11831:SF4; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01017; rpsD_bact; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..200
FT /note="30S ribosomal protein S4"
FT /id="PRO_0000293375"
FT DOMAIN 92..155
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01306"
FT HELIX 10..13
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 19..22
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 46..61
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 65..73
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 76..80
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 82..90
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 94..100
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 103..106
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 107..115
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 119..121
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 124..126
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 138..140
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 149..156
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 165..168
FT /evidence="ECO:0007829|PDB:7BGD"
FT TURN 169..172
FT /evidence="ECO:0007829|PDB:7BGD"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:7BGD"
FT HELIX 192..195
FT /evidence="ECO:0007829|PDB:7BGD"
FT TURN 196..199
FT /evidence="ECO:0007829|PDB:7BGD"
SQ SEQUENCE 200 AA; 23013 MW; E4BBB131EF37A6ED CRC64;
MARFRGSNWK KSRRLGISLS GTGKELEKRP YAPGQHGPNQ RKKLSEYGLQ LREKQKLRYL
YGMTERQFRN TFDIAGKKFG VHGENFMILL ASRLDAVVYS LGLARTRRQA RQLVNHGHIL
VDGKRVDIPS YSVKPGQTIS VREKSQKLNI IVESVEINNF VPEYLNFDAD SLTGTFVRLP
ERSELPAEIN EQLIVEYYSR
