ABCA_ASPFU
ID ABCA_ASPFU Reviewed; 1452 AA.
AC Q4WR59;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=ABC multidrug transporter A-1 {ECO:0000305};
GN Name=abcA {ECO:0000303|PubMed:12172968}; ORFNames=AFUA_1G17440;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=12172968; DOI=10.1007/s00294-002-0313-z;
RA Langfelder K., Gattung S., Brakhage A.A.;
RT "A novel method used to delete a new Aspergillus fumigatus ABC transporter-
RT encoding gene.";
RL Curr. Genet. 41:268-274(2002).
CC -!- FUNCTION: ABC transporter that seems not to be involved in the efflux
CC of toxic substances, at least not the classical compounds such as
CC itraconazole, amphotericin B, voriconazole, posaconazole, ravuconazole,
CC or echinocandins. {ECO:0000269|PubMed:12172968}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Does not lead to growth defects or changes in
CC developmental patterns and does not affect sensitivity to itraconazole,
CC amphotericin B, voriconazole, posaconazole, ravuconazole, or
CC echinocandins. {ECO:0000269|PubMed:12172968}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AAHF01000004; EAL91073.1; -; Genomic_DNA.
DR RefSeq; XP_753111.1; XM_748018.1.
DR AlphaFoldDB; Q4WR59; -.
DR SMR; Q4WR59; -.
DR STRING; 330879.Q4WR59; -.
DR EnsemblFungi; EAL91073; EAL91073; AFUA_1G17440.
DR GeneID; 3510143; -.
DR KEGG; afm:AFUA_1G17440; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; Q4WR59; -.
DR OMA; TFAHFMI; -.
DR OrthoDB; 37708at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1452
FT /note="ABC multidrug transporter A-1"
FT /id="PRO_0000445094"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 725..745
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1153..1173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1183..1203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1223..1243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1271..1291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1297..1317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1324..1344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1418..1438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 110..363
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 802..1044
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 838..845
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 287
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1391
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 1452 AA; 163263 MW; 86B22871D15F116B CRC64;
MNESHEAGKN SSTNVEEREE EVLRLARQFT EQSSYSTAGQ TPFAAEAGSA LDPNGERFNA
RAWCKAMLQM HIGDKEAHPL RTLGVAFSNL NVHGFGSDTD YQKSVGNVWL KTLSLARIAF
GQKQRKVDIL QNLEGLVEAG EMLVVLGPPG SGCSTFLKTI AGETYGFHVD KNSNINFQGI
AKQMAHEFRG EAIYTAEVDV HFPKLTVGDT LYFAARARTP RHIPGGVNAT QYAGHMRDVI
MAMFGISHTK NTIVGNDFIR GVSGGERKRV SIAEACLSNA PLQCWDNSTR GLDSANAIEF
CKTLRMQADI NGTTACVSLY QAPQAAYDYF DKVLVLYEGR EIYFGPTSMA KHYFLQMGFV
CPDRQTDADF LTSMTSHLER VVQPGYEDRV PRTPDEFAAR WKASPQRAQL MQHIKSYNAK
FALDGEYLDK FKQSRRAQQA KAQRVSSPYT LSYVQQVKLC LWRGYQRLKA DPSVTISSLF
GNTIISLVIA SIFYNLKADT STFFQRGALL FFAVLMNALG CGLEMLTLYA QRGIIEKHSR
YALYHPSAEA FSSMIMDLPY KILNAITSNI VLYFMTNLRR EPGAFFFFVF TSFILTLTMS
MFFRSMASLS RSLVQVLPFS AVLLLGLSMY TGFAIPTGYM LGWARWIAYI NPISYGFESL
MINEFHNRDF PCMDYVPSGP GYTDVGLNNR VCSTVRSVPG QAFVNGNAYI ESAYSYTASH
KWRNIGVIFA YMFLLGAVYL VATDFITEKK PKGEILVFPR GHKALKKGKS DEDLEGGGGR
SATVEKIGSD GLAMIERQTA IFQWKDVCFD IKIGKENCRI LDHVDGWVKP GILTALMGVS
GAGKTTLLDV LATRTTMGII SGEMLVDGQP RDESFQRKTG YAQQQDLHLS TATVREALEF
SALLRQSAHV PRQEKIDYVT EVIKLLDMTE YADAVIGVPG EGLNVEQRKR LTIGVELAAR
PQLLLFLDEP TSGLDSQTSW AILDLLDKLK KNGQAILCTI HQPSAMLFQR FDRLLFLQAG
GRTVYFGEIG QNSQILIDYF VRNGAPPCPP DANPAEWMLD VIGAAPGSHT SINWFETWRR
SPEYARVQEH LAELKHERRH QTNLFRTTSG QKREDKDSYR EFAAPFWAQL YQVQVRVFQQ
IWRSPTYIYS KTALCVLSAL FVGFSLFHTP NTIQGLQNQM FGIFMLLTLF GQLIQQIMPH
FVAQRALYEV RDRPAKTYSW KAFLIANIVV ELPWNSLMSV LMFLCWYYPI GLYRNAEPTD
AVHLRGTQMW LMIWTFLLFS STFAHFMIAA FDAAENAGNL GNLLFLLCLL FCGVLATPDQ
LPRFWIFMYR VSPFTYLVSG MLSVGISNTN VTCADNEYLR FDPVNGTCGE YMGSYMSNLG
GYLADEMATA NCSFCPIKET NVFLGRVSSS YSDIWRNFGL MWVFIVFNIF AACSLYWWVR
VPRDKKPVAK AE
