ID   BAMBI_SHEEP             Reviewed;         260 AA.
AC   Q8HYZ0;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=BMP and activin membrane-bound inhibitor homolog;
DE   Flags: Precursor;
GN   Name=BAMBI;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Souza C.J.H., McNeilly A.S., Baird D.T.;
RT   "BMP antagonist expression in the sheep ovary.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates TGF-beta signaling. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BAMBI family. {ECO:0000305}.
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DR   EMBL; AY147883; AAN63055.1; -; mRNA.
DR   RefSeq; NP_001009761.1; NM_001009761.1.
DR   AlphaFoldDB; Q8HYZ0; -.
DR   STRING; 9940.ENSOARP00000016286; -.
DR   Ensembl; ENSOART00020031283; ENSOARP00020025846; ENSOARG00020020313.
DR   GeneID; 443242; -.
DR   KEGG; oas:443242; -.
DR   CTD; 25805; -.
DR   eggNOG; ENOG502QXJJ; Eukaryota.
DR   OrthoDB; 1225762at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005109; F:frizzled binding; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR009345; BAMBI.
DR   InterPro; IPR045806; BAMBI_C.
DR   InterPro; IPR045807; BAMBI_N.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR15505:SF1; PTHR15505:SF1; 2.
DR   Pfam; PF06211; BAMBI; 1.
DR   Pfam; PF19337; BAMBI_C; 1.
DR   PIRSF; PIRSF037456; BAMBI; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..260
FT                   /note="BMP and activin membrane-bound inhibitor homolog"
FT                   /id="PRO_0000020782"
FT   TOPO_DOM        27..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29116 MW;  BDB7ED041568763A CRC64;
     MDRHSSYIFV WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN
     TNSPLTHGCL DSLASTADIC QARQARNHSG SPLPSLECCH EDMCNYRGLQ DVLTPPKGEA
     SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN
     KRLQEQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSHD
     RILSLVHWGM YSGHGKLEFV