ID   RS4_TETTH               Reviewed;         259 AA.
AC   P0C233;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=40S ribosomal protein S4;
DE   AltName: Full=40S ribosomal protein S7;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   PROTEIN SEQUENCE, AND PHOSPHORYLATION AT THR-248 AND SER-258.
RX   PubMed=7890730; DOI=10.1074/jbc.270.11.6000;
RA   Palm L., Andersen J., Rahbek-Nielsen H., Hansen T.S., Kristiansen K.,
RA   Hoejrup P.;
RT   "The phosphorylated ribosomal protein S7 in Tetrahymena is homologous with
RT   mammalian S4 and the phosphorylated residues are located in the C-terminal
RT   region. Structural characterization of proteins separated by two-
RT   dimensional polyacrylamide gel electrophoresis.";
RL   J. Biol. Chem. 270:6000-6005(1995).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC       {ECO:0000305}.
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DR   PDB; 4BTS; X-ray; 3.70 A; W=1-259.
DR   PDB; 4V5O; X-ray; 3.93 A; AW/BW=1-259.
DR   PDB; 5JPQ; EM; 7.30 A; p=1-259.
DR   PDBsum; 4BTS; -.
DR   PDBsum; 4V5O; -.
DR   PDBsum; 5JPQ; -.
DR   AlphaFoldDB; P0C233; -.
DR   SMR; P0C233; -.
DR   IntAct; P0C233; 1.
DR   iPTMnet; P0C233; -.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd06087; KOW_RPS4; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.740; -; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   HAMAP; MF_00485; Ribosomal_S4e; 1.
DR   InterPro; IPR032277; 40S_S4_C.
DR   InterPro; IPR041982; KOW_RPS4.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central_region.
DR   InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11581; PTHR11581; 1.
DR   Pfam; PF16121; 40S_S4_C; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   PROSITE; PS00528; RIBOSOMAL_S4E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Phosphoprotein; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..259
FT                   /note="40S ribosomal protein S4"
FT                   /id="PRO_0000260291"
FT   DOMAIN          41..105
FT                   /note="S4 RNA-binding"
FT   MOD_RES         248
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:7890730"
FT   MOD_RES         258
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:7890730"
SQ   SEQUENCE   259 AA;  29462 MW;  F3213BDDB5F3C103 CRC64;
     ARGPKKHLKR INAPKSWMLN KLGGIWATRP SQGPHKLRES LPLSVLLKER LNYALNGRDV
     TLILNDKEGN VFVDQKVRRD KGYPTGLMDV VRIEKTDQSF RILYDTKGRF VLKSLSKEEA
     KYKLLKVTAK AIGPNQIPYI VTHDSRTIRF PNPEIKIGDT LKYDLVNNKI ENFAHLESGN
     VCYIQQGNNI GRVGIIQHIE KHQGSFDICH VKDAKGNAFA TRLGNIFVLG QGKKLYIELP
     SGDGVRETIL EERKRKFSY