RS4_THET2
ID RS4_THET2 Reviewed; 209 AA.
AC P62664;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=30S ribosomal protein S4;
GN Name=rpsD; Synonyms=rps4; OrderedLocusNames=TT_C1301;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it helps nucleate assembly of the body and platform
CC of the 30S subunit. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts protein S5. The
CC interaction surface between S4 and S5 is involved in control of
CC translational fidelity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; AE017221; AAS81643.1; -; Genomic_DNA.
DR RefSeq; WP_011173699.1; NC_005835.1.
DR PDB; 4KVB; X-ray; 4.20 A; D=1-209.
DR PDB; 4V4I; X-ray; 3.71 A; e=1-209.
DR PDB; 4V4J; X-ray; 3.83 A; e=1-209.
DR PDB; 4V63; X-ray; 3.21 A; AD/CD=1-209.
DR PDB; 4V67; X-ray; 3.00 A; AD/CD=1-209.
DR PDB; 4V7P; X-ray; 3.62 A; AD/DD=2-209.
DR PDB; 4V83; X-ray; 3.50 A; AD/CD=2-209.
DR PDB; 4V84; X-ray; 3.40 A; AD/CD=2-209.
DR PDB; 4V9J; X-ray; 3.86 A; AD/CD=2-209.
DR PDB; 4V9K; X-ray; 3.50 A; AD/CD=2-209.
DR PDB; 4V9L; X-ray; 3.50 A; AD/CD=2-209.
DR PDB; 4V9M; X-ray; 4.00 A; AD/CD=2-209.
DR PDB; 4V9N; X-ray; 3.40 A; AD/CD=2-209.
DR PDB; 4V9Q; X-ray; 3.40 A; BD/DD=2-209.
DR PDB; 4W29; X-ray; 3.80 A; AD/CD=2-209.
DR PDB; 4XEJ; X-ray; 3.80 A; AS04/BS04=2-209.
DR PDB; 5J4D; X-ray; 3.10 A; MA/RC=1-209.
DR PDBsum; 4KVB; -.
DR PDBsum; 4V4I; -.
DR PDBsum; 4V4J; -.
DR PDBsum; 4V63; -.
DR PDBsum; 4V67; -.
DR PDBsum; 4V7P; -.
DR PDBsum; 4V83; -.
DR PDBsum; 4V84; -.
DR PDBsum; 4V9J; -.
DR PDBsum; 4V9K; -.
DR PDBsum; 4V9L; -.
DR PDBsum; 4V9M; -.
DR PDBsum; 4V9N; -.
DR PDBsum; 4V9Q; -.
DR PDBsum; 4W29; -.
DR PDBsum; 4XEJ; -.
DR PDBsum; 5J4D; -.
DR AlphaFoldDB; P62664; -.
DR SMR; P62664; -.
DR IntAct; P62664; 4.
DR STRING; 262724.TT_C1301; -.
DR EnsemblBacteria; AAS81643; AAS81643; TT_C1301.
DR GeneID; 3168006; -.
DR KEGG; tth:TT_C1301; -.
DR eggNOG; COG0522; Bacteria.
DR HOGENOM; CLU_092403_0_1_0; -.
DR OMA; NVVFRMG; -.
DR OrthoDB; 1211060at2; -.
DR EvolutionaryTrace; P62664; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_01306_B; Ribosomal_S4_B; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR005709; Ribosomal_S4_bac-type.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR PANTHER; PTHR11831:SF4; PTHR11831:SF4; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01017; rpsD_bact; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..209
FT /note="30S ribosomal protein S4"
FT /id="PRO_0000132482"
FT DOMAIN 100..162
FT /note="S4 RNA-binding"
FT ZN_FING 9..31
FT /note="C4-type"
FT BINDING 9
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 12
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 31
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 12..15
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 24..27
FT /evidence="ECO:0007829|PDB:4V67"
FT TURN 33..35
FT /evidence="ECO:0007829|PDB:4V67"
FT TURN 41..43
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 44..46
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 53..68
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 72..84
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 89..99
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 101..107
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 109..113
FT /evidence="ECO:0007829|PDB:4V63"
FT HELIX 114..122
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 145..148
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 150..153
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 156..163
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 165..167
FT /evidence="ECO:0007829|PDB:4V84"
FT STRAND 174..177
FT /evidence="ECO:0007829|PDB:4V67"
FT TURN 178..181
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 182..185
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 191..193
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 200..206
FT /evidence="ECO:0007829|PDB:4V67"
SQ SEQUENCE 209 AA; 24324 MW; 0FF3911816971236 CRC64;
MGRYIGPVCR LCRREGVKLY LKGERCYSPK CAMERRPYPP GQHGQKRARR PSDYAVRLRE
KQKLRRIYGI SERQFRNLFE EASKKKGVTG SVFLGLLESR LDNVVYRLGF AVSRRQARQL
VRHGHITVNG RRVDLPSYRV RPGDEIAVAE KSRNLELIRQ NLEAMKGRKV GPWLSLDVEG
MKGKFLRLPD REDLALPVNE QLVIEFYSR
