ABCB1_DICDI
ID ABCB1_DICDI Reviewed; 909 AA.
AC Q54BU4; Q8T9W6;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=ABC transporter B family member 1;
DE AltName: Full=ABC transporter ABCB.1;
GN Name=abcB1; Synonyms=mrpA; ORFNames=DDB_G0293416;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC {ECO:0000305}.
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DR EMBL; AF466304; AAL74248.1; -; Genomic_DNA.
DR EMBL; AAFI02000208; EAL60729.1; -; Genomic_DNA.
DR RefSeq; XP_629144.1; XM_629142.1.
DR AlphaFoldDB; Q54BU4; -.
DR SMR; Q54BU4; -.
DR STRING; 44689.DDB0201666; -.
DR PaxDb; Q54BU4; -.
DR EnsemblProtists; EAL60729; EAL60729; DDB_G0293416.
DR GeneID; 8629215; -.
DR KEGG; ddi:DDB_G0293416; -.
DR dictyBase; DDB_G0293416; abcB1.
DR eggNOG; KOG0058; Eukaryota.
DR HOGENOM; CLU_319700_0_0_1; -.
DR InParanoid; Q54BU4; -.
DR OMA; ATPMVTK; -.
DR PhylomeDB; Q54BU4; -.
DR Reactome; R-DDI-1369007; Mitochondrial ABC transporters.
DR Reactome; R-DDI-159418; Recycling of bile acids and salts.
DR Reactome; R-DDI-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-9754706; Atorvastatin ADME.
DR PRO; PR:Q54BU4; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..909
FT /note="ABC transporter B family member 1"
FT /id="PRO_0000391322"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 350..633
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 666..902
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 701..708
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 903
FT /note="R -> S (in Ref. 1; AAL74248)"
FT /evidence="ECO:0000305"
FT CONFLICT 909
FT /note="D -> G (in Ref. 1; AAL74248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 909 AA; 101293 MW; BC1A166F6CCDD083 CRC64;
MTKKNFNDEE NESLLETYNK QQQKQSISTT NRSDQKFGIN NANKQFSLNN KKSINGEEID
EEELIEDTIF FKFKLDSKQR NSIKLFIQIV SLVILAGYLI SINALYFSTN ARSIIFYPSI
NSNTTDSGSV SPTSTPSPTP TPTPSPTSLL LQTLTSTTTS YDSSEIEALN GGTFNMKYFF
YFSTFDILLI SYFISLFWLL LIFSDSFIYH TISYIITIIA LIYNVIKSYF TITQILSINN
NIITTSSSSN EIYNGSDSYL PNESPLFDSL KVREIIIVIV LVGIPLMVLF LVLHIITLQL
SFKKYKRLSD KEKQFYNQSN EEKRLNKKVE VKHSNLKRLI QLSRPELPII LAAMVALVFS
SLTSLAMPYF FGSIVQVVAT THSFNNLNSS TLALVVIFVI GSISTLVRSW LFYLAGQKFV
ARIRRNLFSS IVNQEIGYFD QCRTGELLSR LSSDSQVIQN SVTVNISMLF RYTIQIIGSV
ILLFITNWRL TLLMLGIVPV LAISTVVYGK KIKQLGKQFQ DELAKSSTTG EEVISNIRTV
RSFSKEQKFI DLYSKDINGS YLIGKSLAVA TGVFSGIVFL VAQLAIVLIV YVGARQVLDG
TLSTGDLTSF LLYTLSLAMS LAFISSLMTD FLKAIGSSDR IFEIFDRVPA INVSGGKQIQ
NPLGEIELKD VEFSYPTRPN NSVLKGLNLK LSKGTITALV GPSGGGKSTV IAMIERFYDP
NSGSITFDGI DIKELDPVWY RGIIGYVSQE PVLFAGSIKD NITFGNDSAT MDQIISAAEK
ANAHSFIEEF ENGYDTIVGE RGVRLSGGQK QRVAIARAMI QNPMILLLDE ATSALDAESE
YLVKQAIDEI MKDRTVIVIA HRLSTVINAN TVVVINQGKI EEMGTHKELL NNTDGIYHNL
VKRQLSSDD
