ABCB4_DICDI
ID ABCB4_DICDI Reviewed; 767 AA.
AC Q54W24; Q8T9W3;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=ABC transporter B family member 4;
DE AltName: Full=ABC transporter ABCB.4;
GN Name=abcB4; ORFNames=DDB_G0279915;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF466307; AAL74251.2; -; Genomic_DNA.
DR EMBL; AAFI02000035; EAL67429.1; -; Genomic_DNA.
DR RefSeq; XP_641426.1; XM_636334.1.
DR AlphaFoldDB; Q54W24; -.
DR SMR; Q54W24; -.
DR STRING; 44689.DDB0208540; -.
DR PaxDb; Q54W24; -.
DR EnsemblProtists; EAL67429; EAL67429; DDB_G0279915.
DR GeneID; 8622310; -.
DR KEGG; ddi:DDB_G0279915; -.
DR dictyBase; DDB_G0279915; abcB4.
DR eggNOG; KOG0058; Eukaryota.
DR HOGENOM; CLU_000604_84_3_1; -.
DR InParanoid; Q54W24; -.
DR OMA; RVMHDLR; -.
DR PhylomeDB; Q54W24; -.
DR Reactome; R-DDI-1369007; Mitochondrial ABC transporters.
DR Reactome; R-DDI-159418; Recycling of bile acids and salts.
DR Reactome; R-DDI-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-9754706; Atorvastatin ADME.
DR PRO; PR:Q54W24; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IGC:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..767
FT /note="ABC transporter B family member 4"
FT /id="PRO_0000391325"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 211..491
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 524..760
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 81..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 559..566
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 7
FT /note="C -> S (in Ref. 1; AAL74251)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="V -> G (in Ref. 1; AAL74251)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="G -> W (in Ref. 1; AAL74251)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 767 AA; 85337 MW; 65359AA44667F1DA CRC64;
MNSLLRCCLI KPINIKNTTS FINKLNPKSI IQKSNNYNNI NKNILNKFKD SSSNYFINSN
KILEICNNNN NNNKYNVNKR NYSSSSNSGN NNNNNYNNKN NNNNNESFYK KFENSFEIKR
IKDILFIIVG TFVIFKIYDN KIGIVFCENE IDKETILNDP YDKIPNEIIV ELKDSAKDDN
IIEESDEDDG IKKISSFKLF FKTIGNDIWL FGFGIITAFF SSWVGLQIPK VFGVLIDCTK
NGDSLQGPAI QAIFILLAQA GLNFLYSTMI SVACERYSAR LRSTLFGAML EQEIGFFDQN
STGDLINRLS SDVQLVRSAL KHSVSLGVKS FGQIVGGVIS LILISPKLSL GMMTILPTMV
SVGTFYAGWL KSLSVRSQRA QAQSTIVAEE AIGNIRTVQA FSNQHYESER FIEKNQHSLA
LSTESGVQIG IFQGVTSLAL NSVSLLVYWY GGTLVSRGEM TGGQLTSFII HTMNMQSSFS
QLSILFTQIM SAMGGMQRIT ELINRVPLIN SNQGFKLREL KGEIKFINVD FKYPTRPHVH
VLNGLNLTLK PGQVVALAGS SGGGKSTIAG LLERFYDISN GDITIDGYSI KQLNAKWLRS
RIGIVSQEPS LFATTILENL RYGNPNATED EIIEAAKLAN AHQFISNFPK GYETIVGERG
VQLSGGQKQR IAIARAILKN PQIIILDEAT SALDSQSELL VQTALDNLMK GRTTLVIAHR
LSTVQNADLI GVLSHGKIAE FGNHNELMNH KGLYYKLVQR QLSQQQQ
