ABCB5_DICDI
ID ABCB5_DICDI Reviewed; 697 AA.
AC Q8T9W2; Q54D24;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ABC transporter B family member 5;
DE AltName: Full=ABC transporter ABCB.5;
GN Name=abcB5; ORFNames=DDB_G0292554;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Metal importer (TC 3.A.1.210) subfamily. {ECO:0000305}.
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DR EMBL; AF466308; AAL74252.1; -; Genomic_DNA.
DR EMBL; AAFI02000194; EAL61080.1; -; Genomic_DNA.
DR RefSeq; XP_629496.1; XM_629494.1.
DR AlphaFoldDB; Q8T9W2; -.
DR SMR; Q8T9W2; -.
DR STRING; 44689.DDB0201625; -.
DR PaxDb; Q8T9W2; -.
DR EnsemblProtists; EAL61080; EAL61080; DDB_G0292554.
DR GeneID; 8628745; -.
DR KEGG; ddi:DDB_G0292554; -.
DR dictyBase; DDB_G0292554; abcB5.
DR eggNOG; KOG0057; Eukaryota.
DR HOGENOM; CLU_000604_84_1_1; -.
DR InParanoid; Q8T9W2; -.
DR OMA; VTEWRTH; -.
DR PhylomeDB; Q8T9W2; -.
DR Reactome; R-DDI-1369007; Mitochondrial ABC transporters.
DR PRO; PR:Q8T9W2; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IGC:dictyBase.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..697
FT /note="ABC transporter B family member 5"
FT /id="PRO_0000391326"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 140..426
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 460..695
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 73..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 493..500
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 697 AA; 78531 MW; 304CC7BC2F344F2F CRC64;
MYSINRIGIH GISNKILSRP KFFHSSSSIF SLNQNLNNFK NNNNYILNGY NKITHNHHHQ
TLFHRHYSNL KQEQENKQQN VGKNSETSPS STTTTENITT ATTATTKTDI KETQNSTMSM
LKTVFKYLWP KDNNDSKIRI ITSVLLLLSA KVLTVQIPFI FKDIVDSLTT TQSEMLTLPL
GLLLAYGAVK ITSNGFQELR QTIFSKVAHD AIRDVSCSTF KRLHQLDLTF HLSRQTGSLS
RIIDRGGRGI NFLLNSILFH VVPTAFEISL VSYVMYTTLG WEYSALSLAT IAAYTVFTVK
VTKWRTQFRV KMNKMDNEAS NKMMDSLINF ETVKYFNNDA LEVERYHNYL KEYDKASLKT
TSSLSFLNFG QALIFSLSMT AMMIMAAQGV VQGNLSVGDL VLVNGLLFQI SLPLNFLGTV
YREIKQSLVD MDHLFSLLNL NPKISDNKDS KPLKLENGTI VFRDISFKYN DSVQVLNNVS
FECEGGKRIA IVGSSGSGKS TLLRLLYRFY DVSSGSIEID GQDIRGIQLE SLRKHIGVVP
QDTVLFNDTI YYNIAYGNPN ATKEQVENAA RAAHIHEVIL NMKNGYDTVV GERGLKLSGG
EKQRVSIARA ILKDSPIVFY DEATSSLDTE KEKLIMDALR ELFKGRTTIM IAHRLSTIVD
ADEIIVLGTG GIILERGNHQ QLLELEGKYR SMWLAQQ
