BAMD_NEIMB
ID BAMD_NEIMB Reviewed; 267 AA.
AC Q9K0B1;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Outer membrane protein assembly factor BamD {ECO:0000255|HAMAP-Rule:MF_00922};
DE AltName: Full=Competence lipoprotein ComL;
DE Flags: Precursor;
GN Name=bamD {ECO:0000255|HAMAP-Rule:MF_00922}; Synonyms=comL;
GN OrderedLocusNames=NMB0703;
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58;
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT "Characterization of the protein content of a meningococcal outer membrane
RT vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT spectrometry.";
RL Hum. Vaccin. 1:80-84(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=NZ98/254 / Serogroup B;
RX PubMed=16645985; DOI=10.1002/pmic.200500821;
RA Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.;
RT "Proteomic analysis of a meningococcal outer membrane vesicle vaccine
RT prepared from the group B strain NZ98/254.";
RL Proteomics 6:3400-3413(2006).
CC -!- FUNCTION: Part of the outer membrane protein assembly complex, which is
CC involved in assembly and insertion of beta-barrel proteins into the
CC outer membrane. Required for efficient transformation of Neisseria
CC meningitidis by species-related DNA. {ECO:0000255|HAMAP-Rule:MF_00922}.
CC -!- SUBUNIT: Part of the Bam complex. {ECO:0000255|HAMAP-Rule:MF_00922}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_00922}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00922}.
CC -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC used as vaccines in human.
CC -!- SIMILARITY: Belongs to the BamD family. {ECO:0000255|HAMAP-
CC Rule:MF_00922}.
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DR EMBL; AE002098; AAF41120.1; -; Genomic_DNA.
DR PIR; H81167; H81167.
DR RefSeq; NP_273745.1; NC_003112.2.
DR RefSeq; WP_002244053.1; NC_003112.2.
DR AlphaFoldDB; Q9K0B1; -.
DR SMR; Q9K0B1; -.
DR STRING; 122586.NMB0703; -.
DR PaxDb; Q9K0B1; -.
DR EnsemblBacteria; AAF41120; AAF41120; NMB0703.
DR KEGG; nme:NMB0703; -.
DR PATRIC; fig|122586.8.peg.895; -.
DR HOGENOM; CLU_065982_0_1_4; -.
DR OMA; VERQHPY; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:1990063; C:Bam protein complex; IBA:GO_Central.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR CDD; cd15830; BamD; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR HAMAP; MF_00922; OM_assembly_BamD; 1.
DR InterPro; IPR017689; BamD.
DR InterPro; IPR039565; BamD-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13525; YfiO; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR03302; OM_YfiO; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Competence; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00922"
FT CHAIN 17..267
FT /note="Outer membrane protein assembly factor BamD"
FT /id="PRO_0000036223"
FT LIPID 17
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00922"
FT LIPID 17
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00922"
SQ SEQUENCE 267 AA; 30915 MW; 26B4588A67A7E223 CRC64;
MKKILLTVSL GLALSACATQ GTVDKDAQIT QDWSVEKLYA EAQDELNSSN YTRAVKLYEI
LESRFPTSRH AQQSQLDTAY AYYKDDEKDK ALAAIDRFRR LHPQHPNMDY ALYLRGLVLF
NEDQSFLNKL ASQDWSDRDP KANREAYQAF AELVQRFPNS KYAADATARM VKLVDALGGN
EMSVARYYMK RGAYIAAANR AQKIIGSYQN TRYVEESLAI LELAYKKLDK PRLAADTRRV
LETNFPKSPF LKQPWRSDDM PWWRYWH
