ID   RS6_AEDAE               Reviewed;         346 AA.
AC   Q9U761; Q0C741;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=RpS6; ORFNames=AAEL000032;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10897799; DOI=10.1023/a:1003914513726;
RA   Hernandez V.P., Fallon A.M.;
RT   "Ribosomal protein S6 cDNA from two Aedes mosquitoes encodes a carboxyl-
RT   terminal extension that resembles histone H1 proteins.";
RL   Genetica 106:263-267(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF154067; AAF04790.1; -; mRNA.
DR   EMBL; CH477186; EAT48987.1; -; Genomic_DNA.
DR   EMBL; CH477186; EAT48988.1; -; Genomic_DNA.
DR   RefSeq; XP_001647930.1; XM_001647880.1.
DR   RefSeq; XP_001647931.1; XM_001647881.1.
DR   AlphaFoldDB; Q9U761; -.
DR   SMR; Q9U761; -.
DR   STRING; 7159.AAEL000032-PC; -.
DR   GeneID; 5563590; -.
DR   KEGG; aag:5563590; -.
DR   VEuPathDB; VectorBase:AAEL000032; -.
DR   eggNOG; KOG1646; Eukaryota.
DR   InParanoid; Q9U761; -.
DR   OMA; SEFKGYI; -.
DR   OrthoDB; 1326714at2759; -.
DR   PhylomeDB; Q9U761; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..346
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137321"
FT   REGION          224..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        245
FT                   /note="K -> E (in Ref. 1; AAF04790)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294
FT                   /note="A -> S (in Ref. 1; AAF04790)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        342
FT                   /note="K -> N (in Ref. 1; AAF04790)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   346 AA;  39362 MW;  362A241BEC2527CB CRC64;
     MKLNVSFPAT GAQKTFEVMD DHKLRHFYDK RMGAEITADH LGDEWKGYVF KIAGGNDKQG
     FPMKQGVLTN TRVRLLLKKG HSCYRPRRTG ERKRKSVRGC IVDQNLSALA LIVVKKGEKD
     IPGLTDTTVP RRLGPKRASN IRKLYNLTKE DDVRQFVVKR PLPEKDGKKA RTKAPKIQRL
     ITPVVLQRKR HRLAIKKRRV ESRKEAEAEY MKILHLRRRQ ERIRRRSRLS SMRDSRSSVG
     EERDKEKEKA AAKAAKKVAK KEAKKEVKKV TEAAKKADAK AKTKAEPKKA EKKAETGKKT
     AGDKKEKKVE KKAAPAVAKK EAPKRKPEAA KGDASAAKKE KKQKKK