BANK1_HUMAN
ID BANK1_HUMAN Reviewed; 785 AA.
AC Q8NDB2; A8K7W8; B0F3S2; Q8N5K8; Q8NB56; Q8WYN5; Q9NWP2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=B-cell scaffold protein with ankyrin repeats;
GN Name=BANK1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY,
RP PHOSPHORYLATION, INTERACTION WITH LYN; ITPR1 AND ITPR2, FUNCTION, AND
RP VARIANT ARG-650.
RC TISSUE=B-cell;
RX PubMed=11782428; DOI=10.1093/emboj/21.1.83;
RA Yokoyama K., Su I., Tezuka T., Yasuda T., Mikoshiba K., Tarakhovsky A.,
RA Yamamoto T.;
RT "BANK regulates BCR-induced calcium mobilization by promoting tyrosine
RT phosphorylation of IP3 receptor.";
RL EMBO J. 21:83-92(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, POSSIBLE
RP INVOLVEMENT IN SLE, AND VARIANTS HIS-61; THR-383 AND ARG-650.
RX PubMed=18204447; DOI=10.1038/ng.79;
RA Kozyrev S.V., Abelson A.-K., Wojcik J., Zaghlool A., Linga Reddy M.V.P.,
RA Sanchez E., Gunnarsson I., Svenungsson E., Sturfelt G., Joensen A.,
RA Truedsson L., Pons-Estel B.A., Witte T., D'Alfonso S., Barizzone N.,
RA Danieli M.G., Gutierrez C., Suarez A., Junker P., Laustrup H.,
RA Gonzalez-Escribano M.F., Martin J., Abderrahim H., Alarcon-Riquelme M.E.;
RT "Functional variants in the B-cell gene BANK1 are associated with systemic
RT lupus erythematosus.";
RL Nat. Genet. 40:211-216(2008).
RN [3]
RP ERRATUM OF PUBMED:18204447.
RA Kozyrev S.V., Abelson A.-K., Wojcik J., Zaghlool A., Linga Reddy M.V.P.,
RA Sanchez E., Gunnarsson I., Svenungsson E., Sturfelt G., Joensen A.,
RA Truedsson L., Pons-Estel B.A., Witte T., D'Alfonso S., Barizzone N.,
RA Danieli M.G., Gutierrez C., Suarez A., Junker P., Laustrup H.,
RA Gonzalez-Escribano M.F., Martin J., Abderrahim H., Alarcon-Riquelme M.E.;
RL Nat. Genet. 40:484-484(2008).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS
RP THR-383 AND ARG-650.
RC TISSUE=Brain, Ileal mucosa, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-650.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-650.
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization
CC from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3
CC receptors 1 and 2. {ECO:0000269|PubMed:11782428}.
CC -!- SUBUNIT: Interacts with LYN, ITPR1 and ITPR2.
CC {ECO:0000269|PubMed:11782428}.
CC -!- INTERACTION:
CC Q8NDB2; P51451: BLK; NbExp=6; IntAct=EBI-2837677, EBI-2105445;
CC Q8NDB2; P07948: LYN; NbExp=3; IntAct=EBI-2837677, EBI-79452;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NDB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDB2-2; Sequence=VSP_020804, VSP_020805;
CC Name=3;
CC IsoId=Q8NDB2-3; Sequence=VSP_020803;
CC Name=4; Synonyms=delta2;
CC IsoId=Q8NDB2-4; Sequence=VSP_034214;
CC -!- TISSUE SPECIFICITY: Expressed in B-cell but not T-cell or myeloid cell
CC lines. Highest expression in CD19(+) B-cells, with very low expression
CC in other cell populations. {ECO:0000269|PubMed:11782428,
CC ECO:0000269|PubMed:18204447}.
CC -!- PTM: Phosphorylated on tyrosines upon BCR activation.
CC {ECO:0000269|PubMed:11782428}.
CC -!- DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic,
CC relapsing, inflammatory, and often febrile multisystemic disorder of
CC connective tissue, characterized principally by involvement of the
CC skin, joints, kidneys and serosal membranes. It is of unknown etiology,
CC but is thought to represent a failure of the regulatory mechanisms of
CC the autoimmune system. The disease is marked by a wide range of system
CC dysfunctions, an elevated erythrocyte sedimentation rate, and the
CC formation of LE cells in the blood or bone marrow.
CC {ECO:0000269|PubMed:18204447}. Note=Disease susceptibility may be
CC associated with variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91337.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB063170; BAB79255.1; -; mRNA.
DR EMBL; EU051376; ABW74340.1; -; mRNA.
DR EMBL; AK000713; BAA91337.1; ALT_FRAME; mRNA.
DR EMBL; AK091523; BAC03685.1; -; mRNA.
DR EMBL; AK292133; BAF84822.1; -; mRNA.
DR EMBL; AL834291; CAD38965.2; -; mRNA.
DR EMBL; AC093694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC095062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032241; AAH32241.2; -; mRNA.
DR CCDS; CCDS34038.1; -. [Q8NDB2-1]
DR CCDS; CCDS47115.1; -. [Q8NDB2-4]
DR CCDS; CCDS47116.1; -. [Q8NDB2-3]
DR RefSeq; NP_001077376.2; NM_001083907.2. [Q8NDB2-3]
DR RefSeq; NP_001120979.2; NM_001127507.2. [Q8NDB2-4]
DR RefSeq; NP_060405.4; NM_017935.4. [Q8NDB2-1]
DR RefSeq; XP_016863826.1; XM_017008337.1. [Q8NDB2-3]
DR AlphaFoldDB; Q8NDB2; -.
DR SMR; Q8NDB2; -.
DR BioGRID; 120354; 7.
DR IntAct; Q8NDB2; 11.
DR MINT; Q8NDB2; -.
DR STRING; 9606.ENSP00000320509; -.
DR iPTMnet; Q8NDB2; -.
DR PhosphoSitePlus; Q8NDB2; -.
DR BioMuta; BANK1; -.
DR DMDM; 308153627; -.
DR EPD; Q8NDB2; -.
DR MassIVE; Q8NDB2; -.
DR MaxQB; Q8NDB2; -.
DR PaxDb; Q8NDB2; -.
DR PeptideAtlas; Q8NDB2; -.
DR PRIDE; Q8NDB2; -.
DR ProteomicsDB; 73007; -. [Q8NDB2-1]
DR ProteomicsDB; 73008; -. [Q8NDB2-2]
DR ProteomicsDB; 73009; -. [Q8NDB2-3]
DR ProteomicsDB; 73010; -. [Q8NDB2-4]
DR Antibodypedia; 51626; 110 antibodies from 26 providers.
DR DNASU; 55024; -.
DR Ensembl; ENST00000322953.9; ENSP00000320509.4; ENSG00000153064.12. [Q8NDB2-1]
DR Ensembl; ENST00000428908.5; ENSP00000412748.1; ENSG00000153064.12. [Q8NDB2-4]
DR Ensembl; ENST00000444316.2; ENSP00000388817.2; ENSG00000153064.12. [Q8NDB2-3]
DR Ensembl; ENST00000504592.5; ENSP00000421443.1; ENSG00000153064.12. [Q8NDB2-2]
DR Ensembl; ENST00000508653.5; ENSP00000422314.1; ENSG00000153064.12. [Q8NDB2-4]
DR GeneID; 55024; -.
DR KEGG; hsa:55024; -.
DR MANE-Select; ENST00000322953.9; ENSP00000320509.4; NM_017935.5; NP_060405.5.
DR UCSC; uc003hvx.4; human. [Q8NDB2-1]
DR CTD; 55024; -.
DR DisGeNET; 55024; -.
DR GeneCards; BANK1; -.
DR HGNC; HGNC:18233; BANK1.
DR HPA; ENSG00000153064; Group enriched (intestine, lymphoid tissue).
DR MalaCards; BANK1; -.
DR MIM; 152700; phenotype.
DR MIM; 610292; gene.
DR neXtProt; NX_Q8NDB2; -.
DR OpenTargets; ENSG00000153064; -.
DR Orphanet; 536; Systemic lupus erythematosus.
DR PharmGKB; PA128394677; -.
DR VEuPathDB; HostDB:ENSG00000153064; -.
DR eggNOG; ENOG502REIM; Eukaryota.
DR GeneTree; ENSGT00390000008787; -.
DR HOGENOM; CLU_012993_1_0_1; -.
DR InParanoid; Q8NDB2; -.
DR OMA; KINIVHH; -.
DR OrthoDB; 280243at2759; -.
DR PhylomeDB; Q8NDB2; -.
DR TreeFam; TF328570; -.
DR PathwayCommons; Q8NDB2; -.
DR SignaLink; Q8NDB2; -.
DR BioGRID-ORCS; 55024; 21 hits in 1066 CRISPR screens.
DR ChiTaRS; BANK1; human.
DR GenomeRNAi; 55024; -.
DR Pharos; Q8NDB2; Tbio.
DR PRO; PR:Q8NDB2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8NDB2; protein.
DR Bgee; ENSG00000153064; Expressed in lymph node and 146 other tissues.
DR Genevisible; Q8NDB2; HS.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ARUK-UCL.
DR GO; GO:0043274; F:phospholipase binding; IPI:ARUK-UCL.
DR GO; GO:0002020; F:protease binding; IPI:ARUK-UCL.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IPI:UniProtKB.
DR GO; GO:0035591; F:signaling adaptor activity; IDA:ARUK-UCL.
DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR GO; GO:0042113; P:B cell activation; IDA:UniProtKB.
DR GO; GO:0050853; P:B cell receptor signaling pathway; TAS:ARUK-UCL.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0050869; P:negative regulation of B cell activation; IBA:GO_Central.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of protein kinase B signaling; IBA:GO_Central.
DR GO; GO:0045947; P:negative regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:UniProtKB.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR Gene3D; 3.40.50.10140; -; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR017893; DBB_domain.
DR InterPro; IPR041340; PIK3AP1_TIR.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR Pfam; PF14545; DBB; 1.
DR Pfam; PF18567; TIR_3; 1.
DR SMART; SM01282; DBB; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS51376; DBB; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; B-cell activation; Phosphoprotein;
KW Reference proteome; Repeat; Systemic lupus erythematosus.
FT CHAIN 1..785
FT /note="B-cell scaffold protein with ankyrin repeats"
FT /id="PRO_0000251927"
FT DOMAIN 25..153
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT DOMAIN 200..327
FT /note="DBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00707"
FT REPEAT 342..371
FT /note="ANK 1"
FT REPEAT 378..408
FT /note="ANK 2"
FT REGION 1..154
FT /note="Interaction with ITPR2"
FT /evidence="ECO:0000269|PubMed:11782428"
FT REGION 433..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..30
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11782428,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_020803"
FT VAR_SEQ 1..14
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020804"
FT VAR_SEQ 15..23
FT /note="PAPCGPAPP -> MVNCHLKI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020805"
FT VAR_SEQ 24..156
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:18204447"
FT /id="VSP_034214"
FT VARIANT 61
FT /note="R -> H (may influence susceptibility to SLE;
FT dbSNP:rs10516487)"
FT /evidence="ECO:0000269|PubMed:18204447"
FT /id="VAR_027729"
FT VARIANT 383
FT /note="A -> T (may influence susceptibility to SLE;
FT dbSNP:rs3733197)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:18204447"
FT /id="VAR_027730"
FT VARIANT 650
FT /note="C -> R (in dbSNP:rs3113676)"
FT /evidence="ECO:0000269|PubMed:11782428,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:18204447"
FT /id="VAR_027731"
FT CONFLICT 143
FT /note="P -> L (in Ref. 4; BAA91337)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="N -> D (in Ref. 4; BAC03685)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="S -> R (in Ref. 4; BAF84822)"
FT /evidence="ECO:0000305"
FT CONFLICT 436
FT /note="H -> R (in Ref. 1; BAB79255)"
FT /evidence="ECO:0000305"
FT CONFLICT 557
FT /note="E -> D (in Ref. 4; BAA91337)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 89282 MW; A4A833E4A13FC6A6 CRC64;
MLPAAPGKGL GSPDPAPCGP APPGNTKDII MIYEEDAEEW ALYLTEVFLH VVKREAILLY
RLENFSFRHL ELLNLTSYKC KLLILSNSLL RDLTPKKCQF LEKILHSPKS VVTLLCGVKS
SDQLYELLNI SQSRWEISTE QEPEDYISVI QSIIFKDSED YFEVNIPTDL RAKHSGEISE
RKEIEELSEA SRNTIPLAVV LPTEIPCENP GEIFIILRDE VIGDTVEVEF TSSNKRIRTR
PALWNKKVWC MKALEFPAGS VHVNVYCDGI VKATTKIKYY PTAKAKECLF RMADSGESLC
QNSIEELDGV LTSIFKHEIP YYEFQSLQTE ICSQNKYTHF KELPTLLHCA AKFGLKNLAI
HLLQCSGATW ASKMKNMEGS DPAHIAERHG HKELKKIFED FSIQEIDINN EQENDYEEDI
ASFSTYIPST QNPAFHHESR KTYGQSADGA EANEMEGEGK QNGSGMETKH SPLEVGSESS
EDQYDDLYVF IPGADPENNS QEPLMSSRPP LPPPRPVANA FQLERPHFTL PGTMVEGQME
RSQNWGHPGV RQETGDEPKG EKEKKEEEKE QEEEEDPYTF AEIDDSEYDM ILANLSIKKK
TGSRSFIINR PPAPTPRPTS IPPKEETTPY IAQVFQQKTA RRQSDDDKFC GLPKKQDRAR
IESPAFSTLR GCLTDGQEEL ILLQEKVKNG KMSMDEALEK FKHWQMGKSG LEMIQQEKLR
QLRDCIIGKR PEEENVYNKL TIVHHPGGKE TAHNENKFYN VHFSNKLPAR PQVEKEFGFC
CKKDH
