ID   RS6_CAEEL               Reviewed;         246 AA.
AC   Q9NEN6;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=rps-6 {ECO:0000312|EMBL:CAB81996.1}; ORFNames=Y71A12B.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000312|EMBL:CAB81996.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:CAB81996.1}
RP   PROTEIN SEQUENCE OF 3-23; 32-46; 116-131; 144-149 AND 156-170, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RA   Bienvenut W.V.;
RL   Submitted (SEP-2005) to UniProtKB.
RN   [3]
RP   FUNCTION.
RX   PubMed=23879233; DOI=10.1111/acel.12140;
RA   Seo K., Choi E., Lee D., Jeong D.E., Jang S.K., Lee S.J.;
RT   "Heat shock factor 1 mediates the longevity conferred by inhibition of TOR
RT   and insulin/IGF-1 signaling pathways in C. elegans.";
RL   Aging Cell 12:1073-1081(2013).
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). Negatively regulates lifespan (PubMed:23879233).
CC       {ECO:0000250|UniProtKB:P62753, ECO:0000269|PubMed:23879233}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000255}.
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DR   EMBL; AL132902; CAB81996.1; -; Genomic_DNA.
DR   RefSeq; NP_493435.1; NM_061034.6.
DR   AlphaFoldDB; Q9NEN6; -.
DR   SMR; Q9NEN6; -.
DR   BioGRID; 38651; 20.
DR   DIP; DIP-25007N; -.
DR   STRING; 6239.Y71A12B.1a; -.
DR   iPTMnet; Q9NEN6; -.
DR   EPD; Q9NEN6; -.
DR   PaxDb; Q9NEN6; -.
DR   PeptideAtlas; Q9NEN6; -.
DR   EnsemblMetazoa; Y71A12B.1a.1; Y71A12B.1a.1; WBGene00004475.
DR   GeneID; 173260; -.
DR   KEGG; cel:CELE_Y71A12B.1; -.
DR   UCSC; Y71A12B.1; c. elegans.
DR   CTD; 173260; -.
DR   WormBase; Y71A12B.1a; CE24592; WBGene00004475; rps-6.
DR   eggNOG; KOG1646; Eukaryota.
DR   GeneTree; ENSGT00390000009819; -.
DR   HOGENOM; CLU_046346_0_1_1; -.
DR   InParanoid; Q9NEN6; -.
DR   OMA; FYEKRMS; -.
DR   OrthoDB; 1326714at2759; -.
DR   PhylomeDB; Q9NEN6; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-166208; mTORC1-mediated signalling.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q9NEN6; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004475; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q9NEN6; baseline and differential.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..246
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137326"
FT   REGION          220..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  28136 MW;  4D2F142DFAA55F59 CRC64;
     MRLNFAYPAT GLQKSFEVDE EKKLRLFFEK RMSQEVAIDA LGDEWKGYVV RIGGGNDKQG
     FPMKQGILTN GRVRLLLKKG QSCYRERKNG ERKRKSVRGC IVDANMSALS LVIVKKGDGE
     IEGLTDSVLP RKLGPKRASK IRKLFNLTKH DDVTKYVITH DKTFPDGVTK TIAPKIQRLI
     TPARIARKKY LLRQKRNQKI KMRDDAAAYH KLLAKYSKEE HDAKIARRRS SASHHSESEV
     KKTSKK