BANP_HUMAN
ID BANP_HUMAN Reviewed; 519 AA.
AC Q8N9N5; A8MU25; A8MX25; B2RCF7; B4DNJ9; F5GZM0; Q96GJ7; Q9NWY1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein BANP;
DE AltName: Full=BEN domain-containing protein 1;
DE AltName: Full=Btg3-associated nuclear protein;
DE AltName: Full=Scaffold/matrix-associated region-1-binding protein;
GN Name=BANP; Synonyms=BEND1, SMAR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7).
RC TISSUE=Peripheral blood monocyte;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=10940556; DOI=10.1016/s0378-1119(00)00244-4;
RA Birot A.-M., Duret L., Bartholin L., Santalucia B., Tigaud I.,
RA Magaud J.-P., Rouault J.-P.;
RT "Identification and molecular analysis of BANP.";
RL Gene 253:189-196(2000).
RN [5]
RP FUNCTION, INTERACTION WITH HDAC1, IDENTIFICATION IN A COMPLEX WITH HDAC1;
RP SIN3A; SIN3B; RBL1 AND RBL2, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=16166625; DOI=10.1128/mcb.25.19.8415-8429.2005;
RA Rampalli S., Pavithra L., Bhatt A., Kundu T.K., Chattopadhyay S.;
RT "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the
RT SIN3/histone deacetylase 1 complex.";
RL Mol. Cell. Biol. 25:8415-8429(2005).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90 AND SER-100, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-133, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Controls V(D)J recombination during T-cell development by
CC repressing T-cell receptor (TCR) beta enhancer function. Binds to
CC scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA
CC sequence located upstream of the TCR beta enhancer. Represses cyclin D1
CC transcription by recruiting HDAC1 to its promoter, thereby diminishing
CC H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which
CC causes cell cycle arrest (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625}.
CC -!- SUBUNIT: Interacts with TP53 (By similarity). Interacts with CUX1/CDP
CC (By similarity). Interacts with HDAC1 (PubMed:16166625). Part of a
CC corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2
CC (PubMed:16166625). {ECO:0000250|UniProtKB:Q8VBU8,
CC ECO:0000269|PubMed:16166625}.
CC -!- INTERACTION:
CC Q8N9N5; Q13444: ADAM15; NbExp=3; IntAct=EBI-744695, EBI-77818;
CC Q8N9N5; Q8WV93: AFG1L; NbExp=3; IntAct=EBI-744695, EBI-2865743;
CC Q8N9N5; P22557: ALAS2; NbExp=3; IntAct=EBI-744695, EBI-2115743;
CC Q8N9N5; Q9UL15: BAG5; NbExp=3; IntAct=EBI-744695, EBI-356517;
CC Q8N9N5; Q6P1W5: C1orf94; NbExp=4; IntAct=EBI-744695, EBI-946029;
CC Q8N9N5; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-744695, EBI-7317823;
CC Q8N9N5; Q13557: CAMK2D; NbExp=4; IntAct=EBI-744695, EBI-351018;
CC Q8N9N5; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-744695, EBI-10271580;
CC Q8N9N5; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-744695, EBI-742887;
CC Q8N9N5; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-744695, EBI-749051;
CC Q8N9N5; Q03692: COL10A1; NbExp=3; IntAct=EBI-744695, EBI-2528309;
CC Q8N9N5; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-744695, EBI-10173222;
CC Q8N9N5; Q8WW22-2: DNAJA4; NbExp=3; IntAct=EBI-744695, EBI-10277181;
CC Q8N9N5; Q5JZY3-3: EPHA10; NbExp=3; IntAct=EBI-744695, EBI-10244652;
CC Q8N9N5; Q6P1L5: FAM117B; NbExp=3; IntAct=EBI-744695, EBI-3893327;
CC Q8N9N5; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-744695, EBI-752049;
CC Q8N9N5; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-744695, EBI-6658203;
CC Q8N9N5; Q14192: FHL2; NbExp=5; IntAct=EBI-744695, EBI-701903;
CC Q8N9N5; Q6PIV2: FOXR1; NbExp=3; IntAct=EBI-744695, EBI-10253815;
CC Q8N9N5; Q969S9: GFM2; NbExp=3; IntAct=EBI-744695, EBI-2371750;
CC Q8N9N5; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-744695, EBI-1047335;
CC Q8N9N5; Q96JM7: L3MBTL3; NbExp=4; IntAct=EBI-744695, EBI-2686809;
CC Q8N9N5; Q96BZ8: LENG1; NbExp=4; IntAct=EBI-744695, EBI-726510;
CC Q8N9N5; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-744695, EBI-10274069;
CC Q8N9N5; P25791: LMO2; NbExp=3; IntAct=EBI-744695, EBI-739696;
CC Q8N9N5; Q8TAP4: LMO3; NbExp=3; IntAct=EBI-744695, EBI-742259;
CC Q8N9N5; P61968: LMO4; NbExp=3; IntAct=EBI-744695, EBI-2798728;
CC Q8N9N5; Q9Y333: LSM2; NbExp=3; IntAct=EBI-744695, EBI-347416;
CC Q8N9N5; Q02750: MAP2K1; NbExp=3; IntAct=EBI-744695, EBI-492564;
CC Q8N9N5; P61244: MAX; NbExp=3; IntAct=EBI-744695, EBI-751711;
CC Q8N9N5; Q53S70: MGC4677; NbExp=3; IntAct=EBI-744695, EBI-10242717;
CC Q8N9N5; Q13084: MRPL28; NbExp=3; IntAct=EBI-744695, EBI-723426;
CC Q8N9N5; Q14511: NEDD9; NbExp=4; IntAct=EBI-744695, EBI-2108053;
CC Q8N9N5; Q9BQI9: NRIP2; NbExp=3; IntAct=EBI-744695, EBI-3913975;
CC Q8N9N5; Q96BD5: PHF21A; NbExp=4; IntAct=EBI-744695, EBI-745085;
CC Q8N9N5; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-744695, EBI-10256685;
CC Q8N9N5; P11309: PIM1; NbExp=3; IntAct=EBI-744695, EBI-696621;
CC Q8N9N5; Q7Z3K3: POGZ; NbExp=5; IntAct=EBI-744695, EBI-1389308;
CC Q8N9N5; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-744695, EBI-10276663;
CC Q8N9N5; P62875: POLR2L; NbExp=3; IntAct=EBI-744695, EBI-359527;
CC Q8N9N5; P23284: PPIB; NbExp=3; IntAct=EBI-744695, EBI-359252;
CC Q8N9N5; P45877: PPIC; NbExp=3; IntAct=EBI-744695, EBI-953909;
CC Q8N9N5; P30405: PPIF; NbExp=3; IntAct=EBI-744695, EBI-5544229;
CC Q8N9N5; O43741: PRKAB2; NbExp=3; IntAct=EBI-744695, EBI-1053424;
CC Q8N9N5; Q9BVQ0: PRKCH; NbExp=3; IntAct=EBI-744695, EBI-10299920;
CC Q8N9N5; O00233: PSMD9; NbExp=3; IntAct=EBI-744695, EBI-750973;
CC Q8N9N5; Q96QF0: RAB3IP; NbExp=3; IntAct=EBI-744695, EBI-747844;
CC Q8N9N5; Q14498-3: RBM39; NbExp=3; IntAct=EBI-744695, EBI-6654703;
CC Q8N9N5; Q93062: RBPMS; NbExp=3; IntAct=EBI-744695, EBI-740322;
CC Q8N9N5; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-744695, EBI-10225873;
CC Q8N9N5; Q8TEC5: SH3RF2; NbExp=3; IntAct=EBI-744695, EBI-2130111;
CC Q8N9N5; O15427: SLC16A3; NbExp=3; IntAct=EBI-744695, EBI-7600166;
CC Q8N9N5; P14678-2: SNRPB; NbExp=3; IntAct=EBI-744695, EBI-372475;
CC Q8N9N5; Q02086: SP2; NbExp=4; IntAct=EBI-744695, EBI-8651703;
CC Q8N9N5; W5XKT8: SPACA6; NbExp=3; IntAct=EBI-744695, EBI-10176265;
CC Q8N9N5; Q53NU3: tmp_locus_54; NbExp=3; IntAct=EBI-744695, EBI-10242677;
CC Q8N9N5; P22105: TNXB; NbExp=4; IntAct=EBI-744695, EBI-2821024;
CC Q8N9N5; O94842: TOX4; NbExp=3; IntAct=EBI-744695, EBI-948613;
CC Q8N9N5; P04637: TP53; NbExp=3; IntAct=EBI-744695, EBI-366083;
CC Q8N9N5; Q12933: TRAF2; NbExp=4; IntAct=EBI-744695, EBI-355744;
CC Q8N9N5; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-744695, EBI-3650647;
CC Q8N9N5; Q12815: TROAP; NbExp=3; IntAct=EBI-744695, EBI-2349743;
CC Q8N9N5; Q9HD64: XAGE1B; NbExp=3; IntAct=EBI-744695, EBI-2340004;
CC Q8N9N5; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-744695, EBI-740767;
CC Q8N9N5; Q8NF64-2: ZMIZ2; NbExp=3; IntAct=EBI-744695, EBI-10182121;
CC Q8N9N5; Q96MN9: ZNF488; NbExp=3; IntAct=EBI-744695, EBI-948288;
CC Q8N9N5; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-744695, EBI-745520;
CC Q8N9N5-2; O94929-2: ABLIM3; NbExp=3; IntAct=EBI-11524452, EBI-11961672;
CC Q8N9N5-2; P22557-2: ALAS2; NbExp=6; IntAct=EBI-11524452, EBI-12257000;
CC Q8N9N5-2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11524452, EBI-12224467;
CC Q8N9N5-2; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-11524452, EBI-14493093;
CC Q8N9N5-2; Q9BQD7: ANTKMT; NbExp=3; IntAct=EBI-11524452, EBI-713602;
CC Q8N9N5-2; Q03989: ARID5A; NbExp=3; IntAct=EBI-11524452, EBI-948603;
CC Q8N9N5-2; P15336: ATF2; NbExp=3; IntAct=EBI-11524452, EBI-1170906;
CC Q8N9N5-2; A0A0S2Z5G4: BANP; NbExp=3; IntAct=EBI-11524452, EBI-16429704;
CC Q8N9N5-2; B4DE54: BANP; NbExp=4; IntAct=EBI-11524452, EBI-16429313;
CC Q8N9N5-2; E9PJI6: BANP; NbExp=3; IntAct=EBI-11524452, EBI-16437731;
CC Q8N9N5-2; Q8N9N5-2: BANP; NbExp=6; IntAct=EBI-11524452, EBI-11524452;
CC Q8N9N5-2; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-11524452, EBI-16429296;
CC Q8N9N5-2; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-11524452, EBI-1012434;
CC Q8N9N5-2; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-11524452, EBI-2548012;
CC Q8N9N5-2; Q96DN7: BOC; NbExp=3; IntAct=EBI-11524452, EBI-12208129;
CC Q8N9N5-2; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-11524452, EBI-946029;
CC Q8N9N5-2; Q9BXJ5: C1QTNF2; NbExp=3; IntAct=EBI-11524452, EBI-2817707;
CC Q8N9N5-2; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-11524452, EBI-12030460;
CC Q8N9N5-2; Q53S99: C2orf83; NbExp=3; IntAct=EBI-11524452, EBI-18232868;
CC Q8N9N5-2; Q3SXR2: C3orf36; NbExp=3; IntAct=EBI-11524452, EBI-18036948;
CC Q8N9N5-2; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-11524452, EBI-12020542;
CC Q8N9N5-2; Q9HC52: CBX8; NbExp=3; IntAct=EBI-11524452, EBI-712912;
CC Q8N9N5-2; Q96LY2-2: CCDC74B; NbExp=3; IntAct=EBI-11524452, EBI-17967022;
CC Q8N9N5-2; O00311: CDC7; NbExp=3; IntAct=EBI-11524452, EBI-374980;
CC Q8N9N5-2; P46527: CDKN1B; NbExp=3; IntAct=EBI-11524452, EBI-519280;
CC Q8N9N5-2; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-11524452, EBI-742887;
CC Q8N9N5-2; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-11524452, EBI-749051;
CC Q8N9N5-2; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-11524452, EBI-12593838;
CC Q8N9N5-2; Q03692: COL10A1; NbExp=6; IntAct=EBI-11524452, EBI-2528309;
CC Q8N9N5-2; O43186: CRX; NbExp=6; IntAct=EBI-11524452, EBI-748171;
CC Q8N9N5-2; P67870: CSNK2B; NbExp=3; IntAct=EBI-11524452, EBI-348169;
CC Q8N9N5-2; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-11524452, EBI-8636823;
CC Q8N9N5-2; O60479: DLX3; NbExp=3; IntAct=EBI-11524452, EBI-3908248;
CC Q8N9N5-2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11524452, EBI-744099;
CC Q8N9N5-2; Q9NQ30: ESM1; NbExp=3; IntAct=EBI-11524452, EBI-12260294;
CC Q8N9N5-2; Q6P1L5: FAM117B; NbExp=4; IntAct=EBI-11524452, EBI-3893327;
CC Q8N9N5-2; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-11524452, EBI-19153639;
CC Q8N9N5-2; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-11524452, EBI-2807642;
CC Q8N9N5-2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11524452, EBI-6658203;
CC Q8N9N5-2; O95363: FARS2; NbExp=4; IntAct=EBI-11524452, EBI-2513774;
CC Q8N9N5-2; Q14192: FHL2; NbExp=6; IntAct=EBI-11524452, EBI-701903;
CC Q8N9N5-2; Q5TD97: FHL5; NbExp=3; IntAct=EBI-11524452, EBI-750641;
CC Q8N9N5-2; O75955: FLOT1; NbExp=3; IntAct=EBI-11524452, EBI-603643;
CC Q8N9N5-2; Q08050: FOXM1; NbExp=3; IntAct=EBI-11524452, EBI-866480;
CC Q8N9N5-2; Q08050-2: FOXM1; NbExp=3; IntAct=EBI-11524452, EBI-5237510;
CC Q8N9N5-2; Q6PIV2: FOXR1; NbExp=3; IntAct=EBI-11524452, EBI-10253815;
CC Q8N9N5-2; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-11524452, EBI-7960826;
CC Q8N9N5-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11524452, EBI-5916454;
CC Q8N9N5-2; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-11524452, EBI-11956675;
CC Q8N9N5-2; Q9NQ87: HEYL; NbExp=3; IntAct=EBI-11524452, EBI-751092;
CC Q8N9N5-2; Q96JK4-2: HHIPL1; NbExp=3; IntAct=EBI-11524452, EBI-12083878;
CC Q8N9N5-2; Q6ZQW0-2: IDO2; NbExp=6; IntAct=EBI-11524452, EBI-12233645;
CC Q8N9N5-2; P05019-2: IGF1; NbExp=3; IntAct=EBI-11524452, EBI-12837046;
CC Q8N9N5-2; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-11524452, EBI-11955401;
CC Q8N9N5-2; Q9C086: INO80B; NbExp=3; IntAct=EBI-11524452, EBI-715611;
CC Q8N9N5-2; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11524452, EBI-4397613;
CC Q8N9N5-2; Q7Z7F0-4: KHDC4; NbExp=3; IntAct=EBI-11524452, EBI-9089060;
CC Q8N9N5-2; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-11524452, EBI-2796400;
CC Q8N9N5-2; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-11524452, EBI-10261141;
CC Q8N9N5-2; P28838: LAP3; NbExp=3; IntAct=EBI-11524452, EBI-2339312;
CC Q8N9N5-2; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-11524452, EBI-10274069;
CC Q8N9N5-2; P56470: LGALS4; NbExp=3; IntAct=EBI-11524452, EBI-720805;
CC Q8N9N5-2; Q969G2: LHX4; NbExp=3; IntAct=EBI-11524452, EBI-2865388;
CC Q8N9N5-2; Q68G74: LHX8; NbExp=3; IntAct=EBI-11524452, EBI-8474075;
CC Q8N9N5-2; Q6MZP7: LIN54; NbExp=3; IntAct=EBI-11524452, EBI-1389411;
CC Q8N9N5-2; P25800: LMO1; NbExp=3; IntAct=EBI-11524452, EBI-8639312;
CC Q8N9N5-2; Q8TAP4-4: LMO3; NbExp=6; IntAct=EBI-11524452, EBI-11742507;
CC Q8N9N5-2; P61968: LMO4; NbExp=3; IntAct=EBI-11524452, EBI-2798728;
CC Q8N9N5-2; Q5T3J3: LRIF1; NbExp=3; IntAct=EBI-11524452, EBI-473196;
CC Q8N9N5-2; Q02750: MAP2K1; NbExp=3; IntAct=EBI-11524452, EBI-492564;
CC Q8N9N5-2; Q99750: MDFI; NbExp=6; IntAct=EBI-11524452, EBI-724076;
CC Q8N9N5-2; P50221: MEOX1; NbExp=3; IntAct=EBI-11524452, EBI-2864512;
CC Q8N9N5-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11524452, EBI-16439278;
CC Q8N9N5-2; Q96E11: MRRF; NbExp=3; IntAct=EBI-11524452, EBI-2855755;
CC Q8N9N5-2; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-11524452, EBI-10699187;
CC Q8N9N5-2; Q7Z6M4: MTERF4; NbExp=3; IntAct=EBI-11524452, EBI-948435;
CC Q8N9N5-2; Q14511-2: NEDD9; NbExp=3; IntAct=EBI-11524452, EBI-11746523;
CC Q8N9N5-2; P23511-2: NFYA; NbExp=3; IntAct=EBI-11524452, EBI-11061759;
CC Q8N9N5-2; Q9HAN9: NMNAT1; NbExp=7; IntAct=EBI-11524452, EBI-3917542;
CC Q8N9N5-2; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-11524452, EBI-17490746;
CC Q8N9N5-2; Q9BQI9: NRIP2; NbExp=3; IntAct=EBI-11524452, EBI-3913975;
CC Q8N9N5-2; Q495U3: PANX2; NbExp=3; IntAct=EBI-11524452, EBI-17242559;
CC Q8N9N5-2; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-11524452, EBI-295391;
CC Q8N9N5-2; P26367: PAX6; NbExp=3; IntAct=EBI-11524452, EBI-747278;
CC Q8N9N5-2; Q96BD5: PHF21A; NbExp=4; IntAct=EBI-11524452, EBI-745085;
CC Q8N9N5-2; A0A0S2Z615: PHF21B; NbExp=3; IntAct=EBI-11524452, EBI-16434035;
CC Q8N9N5-2; Q96EK2-3: PHF21B; NbExp=3; IntAct=EBI-11524452, EBI-16437793;
CC Q8N9N5-2; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-11524452, EBI-10232538;
CC Q8N9N5-2; Q9NPJ4: PNRC2; NbExp=3; IntAct=EBI-11524452, EBI-726549;
CC Q8N9N5-2; Q7Z3K3: POGZ; NbExp=10; IntAct=EBI-11524452, EBI-1389308;
CC Q8N9N5-2; P78424: POU6F2; NbExp=3; IntAct=EBI-11524452, EBI-12029004;
CC Q8N9N5-2; P45877: PPIC; NbExp=3; IntAct=EBI-11524452, EBI-953909;
CC Q8N9N5-2; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11524452, EBI-11320284;
CC Q8N9N5-2; O43741: PRKAB2; NbExp=5; IntAct=EBI-11524452, EBI-1053424;
CC Q8N9N5-2; P17252: PRKCA; NbExp=3; IntAct=EBI-11524452, EBI-1383528;
CC Q8N9N5-2; P86480: PRR20D; NbExp=3; IntAct=EBI-11524452, EBI-12754095;
CC Q8N9N5-2; Q6ZRT6: PRR23B; NbExp=3; IntAct=EBI-11524452, EBI-12845180;
CC Q8N9N5-2; Q9NV39: PRR34; NbExp=3; IntAct=EBI-11524452, EBI-11959565;
CC Q8N9N5-2; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-11524452, EBI-11974061;
CC Q8N9N5-2; Q96QF0-7: RAB3IP; NbExp=6; IntAct=EBI-11524452, EBI-11984839;
CC Q8N9N5-2; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-11524452, EBI-948156;
CC Q8N9N5-2; Q04864-2: REL; NbExp=6; IntAct=EBI-11524452, EBI-10829018;
CC Q8N9N5-2; Q96CP1: RELA; NbExp=3; IntAct=EBI-11524452, EBI-10489476;
CC Q8N9N5-2; Q9BSD3: RHNO1; NbExp=3; IntAct=EBI-11524452, EBI-9658624;
CC Q8N9N5-2; Q15669: RHOH; NbExp=3; IntAct=EBI-11524452, EBI-1244971;
CC Q8N9N5-2; P17081: RHOQ; NbExp=3; IntAct=EBI-11524452, EBI-689202;
CC Q8N9N5-2; P52758: RIDA; NbExp=3; IntAct=EBI-11524452, EBI-1045080;
CC Q8N9N5-2; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-11524452, EBI-366570;
CC Q8N9N5-2; Q8N488: RYBP; NbExp=3; IntAct=EBI-11524452, EBI-752324;
CC Q8N9N5-2; Q5SSQ6-2: SAPCD1; NbExp=3; IntAct=EBI-11524452, EBI-13072754;
CC Q8N9N5-2; Q14524-3: SCN5A; NbExp=3; IntAct=EBI-11524452, EBI-14276801;
CC Q8N9N5-2; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-11524452, EBI-9090795;
CC Q8N9N5-2; O95295: SNAPIN; NbExp=3; IntAct=EBI-11524452, EBI-296723;
CC Q8N9N5-2; P14678-2: SNRPB; NbExp=3; IntAct=EBI-11524452, EBI-372475;
CC Q8N9N5-2; Q9Y5X3-2: SNX5; NbExp=3; IntAct=EBI-11524452, EBI-12229025;
CC Q8N9N5-2; Q02086-2: SP2; NbExp=3; IntAct=EBI-11524452, EBI-9088579;
CC Q8N9N5-2; Q02446: SP4; NbExp=3; IntAct=EBI-11524452, EBI-10198587;
CC Q8N9N5-2; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-11524452, EBI-12023934;
CC Q8N9N5-2; Q8NEQ6: SRARP; NbExp=3; IntAct=EBI-11524452, EBI-17858294;
CC Q8N9N5-2; Q15208: STK38; NbExp=3; IntAct=EBI-11524452, EBI-458376;
CC Q8N9N5-2; Q6ZVD7: STOX1; NbExp=3; IntAct=EBI-11524452, EBI-3923644;
CC Q8N9N5-2; P49848-3: TAF6; NbExp=3; IntAct=EBI-11524452, EBI-12940148;
CC Q8N9N5-2; P22105-1: TNXB; NbExp=3; IntAct=EBI-11524452, EBI-20753895;
CC Q8N9N5-2; O94900: TOX; NbExp=3; IntAct=EBI-11524452, EBI-9088321;
CC Q8N9N5-2; O94842: TOX4; NbExp=6; IntAct=EBI-11524452, EBI-948613;
CC Q8N9N5-2; Q12933: TRAF2; NbExp=3; IntAct=EBI-11524452, EBI-355744;
CC Q8N9N5-2; Q9BUZ4: TRAF4; NbExp=6; IntAct=EBI-11524452, EBI-3650647;
CC Q8N9N5-2; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-11524452, EBI-17716262;
CC Q8N9N5-2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11524452, EBI-9090990;
CC Q8N9N5-2; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-11524452, EBI-2514383;
CC Q8N9N5-2; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11524452, EBI-10180829;
CC Q8N9N5-2; Q14119: VEZF1; NbExp=3; IntAct=EBI-11524452, EBI-11980193;
CC Q8N9N5-2; Q2NL98: VMAC; NbExp=4; IntAct=EBI-11524452, EBI-2803134;
CC Q8N9N5-2; Q9BW85: YJU2; NbExp=3; IntAct=EBI-11524452, EBI-10300345;
CC Q8N9N5-2; P61981: YWHAG; NbExp=3; IntAct=EBI-11524452, EBI-359832;
CC Q8N9N5-2; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-11524452, EBI-2564133;
CC Q8N9N5-2; Q8NF64: ZMIZ2; NbExp=3; IntAct=EBI-11524452, EBI-745786;
CC Q8N9N5-2; O95789-4: ZMYM6; NbExp=3; IntAct=EBI-11524452, EBI-12949277;
CC Q8N9N5-2; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-11524452, EBI-11741890;
CC Q8N9N5-2; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-11524452, EBI-11962468;
CC Q8N9N5-2; Q6S9Z5: ZNF474; NbExp=3; IntAct=EBI-11524452, EBI-17269964;
CC Q8N9N5-2; Q96KM6: ZNF512B; NbExp=3; IntAct=EBI-11524452, EBI-1049952;
CC Q8N9N5-2; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-11524452, EBI-746277;
CC Q8N9N5-2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-11524452, EBI-745520;
CC Q8N9N5-2; A0A1U9X8X8; NbExp=3; IntAct=EBI-11524452, EBI-17234977;
CC Q8N9N5-7; O14627: CDX4; NbExp=3; IntAct=EBI-16429296, EBI-10181162;
CC Q8N9N5-7; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-16429296, EBI-742887;
CC Q8N9N5-7; O43186: CRX; NbExp=3; IntAct=EBI-16429296, EBI-748171;
CC Q8N9N5-7; O60479: DLX3; NbExp=3; IntAct=EBI-16429296, EBI-3908248;
CC Q8N9N5-7; Q14192: FHL2; NbExp=3; IntAct=EBI-16429296, EBI-701903;
CC Q8N9N5-7; Q5TD97: FHL5; NbExp=3; IntAct=EBI-16429296, EBI-750641;
CC Q8N9N5-7; Q08050: FOXM1; NbExp=3; IntAct=EBI-16429296, EBI-866480;
CC Q8N9N5-7; Q08050-2: FOXM1; NbExp=3; IntAct=EBI-16429296, EBI-5237510;
CC Q8N9N5-7; Q96LI6: HSFY2; NbExp=3; IntAct=EBI-16429296, EBI-3957665;
CC Q8N9N5-7; Q99750: MDFI; NbExp=3; IntAct=EBI-16429296, EBI-724076;
CC Q8N9N5-7; P50221: MEOX1; NbExp=3; IntAct=EBI-16429296, EBI-2864512;
CC Q8N9N5-7; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-16429296, EBI-16439278;
CC Q8N9N5-7; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-16429296, EBI-1389308;
CC Q8N9N5-7; P86478: PRR20E; NbExp=3; IntAct=EBI-16429296, EBI-12700196;
CC Q8N9N5-7; Q96QF0-7: RAB3IP; NbExp=3; IntAct=EBI-16429296, EBI-11984839;
CC Q8N9N5-7; Q04864-2: REL; NbExp=3; IntAct=EBI-16429296, EBI-10829018;
CC Q8N9N5-7; Q02446: SP4; NbExp=3; IntAct=EBI-16429296, EBI-10198587;
CC Q8N9N5-7; O94842: TOX4; NbExp=3; IntAct=EBI-16429296, EBI-948613;
CC Q8N9N5-7; Q12933: TRAF2; NbExp=3; IntAct=EBI-16429296, EBI-355744;
CC Q8N9N5-7; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-16429296, EBI-3650647;
CC Q8N9N5-7; Q8NF64: ZMIZ2; NbExp=3; IntAct=EBI-16429296, EBI-745786;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166625}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q8N9N5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N9N5-2; Sequence=VSP_027399, VSP_027400, VSP_027401,
CC VSP_027402;
CC Name=3;
CC IsoId=Q8N9N5-3; Sequence=VSP_027396, VSP_027398, VSP_027399,
CC VSP_027400, VSP_027402;
CC Name=4;
CC IsoId=Q8N9N5-4; Sequence=VSP_027399, VSP_027400, VSP_027401;
CC Name=5;
CC IsoId=Q8N9N5-5; Sequence=VSP_043558, VSP_027399, VSP_027400,
CC VSP_027401;
CC Name=6;
CC IsoId=Q8N9N5-6; Sequence=VSP_027399, VSP_027400, VSP_027402;
CC Name=7;
CC IsoId=Q8N9N5-7; Sequence=VSP_027399, VSP_027401, VSP_027402;
CC -!- TISSUE SPECIFICITY: Down-regulated in breast cancer cell lines.
CC {ECO:0000269|PubMed:16166625}.
CC -!- SIMILARITY: Belongs to the BANP/SMAR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04296.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK000545; BAA91244.1; -; mRNA.
DR EMBL; AK094158; BAC04296.1; ALT_INIT; mRNA.
DR EMBL; AK125232; BAG54171.1; -; mRNA.
DR EMBL; AK297945; BAG60261.1; -; mRNA.
DR EMBL; AK315089; BAG37554.1; -; mRNA.
DR EMBL; AK315535; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC127455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC134312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009424; AAH09424.1; -; mRNA.
DR CCDS; CCDS10966.2; -. [Q8N9N5-4]
DR CCDS; CCDS42215.1; -. [Q8N9N5-2]
DR CCDS; CCDS54052.1; -. [Q8N9N5-7]
DR CCDS; CCDS54053.1; -. [Q8N9N5-6]
DR CCDS; CCDS54054.1; -. [Q8N9N5-1]
DR CCDS; CCDS54055.1; -. [Q8N9N5-5]
DR RefSeq; NP_001167010.1; NM_001173539.1.
DR RefSeq; NP_001167011.1; NM_001173540.1. [Q8N9N5-5]
DR RefSeq; NP_001167012.1; NM_001173541.1. [Q8N9N5-6]
DR RefSeq; NP_001167013.1; NM_001173542.1. [Q8N9N5-7]
DR RefSeq; NP_001167014.1; NM_001173543.1. [Q8N9N5-1]
DR RefSeq; NP_060339.2; NM_017869.3. [Q8N9N5-2]
DR RefSeq; NP_524576.2; NM_079837.2. [Q8N9N5-4]
DR AlphaFoldDB; Q8N9N5; -.
DR SMR; Q8N9N5; -.
DR BioGRID; 120308; 321.
DR CORUM; Q8N9N5; -.
DR IntAct; Q8N9N5; 213.
DR MINT; Q8N9N5; -.
DR STRING; 9606.ENSP00000376902; -.
DR GlyGen; Q8N9N5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N9N5; -.
DR PhosphoSitePlus; Q8N9N5; -.
DR BioMuta; BANP; -.
DR DMDM; 308153628; -.
DR EPD; Q8N9N5; -.
DR jPOST; Q8N9N5; -.
DR MassIVE; Q8N9N5; -.
DR MaxQB; Q8N9N5; -.
DR PaxDb; Q8N9N5; -.
DR PeptideAtlas; Q8N9N5; -.
DR PRIDE; Q8N9N5; -.
DR ProteomicsDB; 25071; -.
DR ProteomicsDB; 72563; -. [Q8N9N5-1]
DR ProteomicsDB; 72564; -. [Q8N9N5-2]
DR ProteomicsDB; 72565; -. [Q8N9N5-3]
DR ProteomicsDB; 72566; -. [Q8N9N5-4]
DR ProteomicsDB; 72567; -. [Q8N9N5-5]
DR ProteomicsDB; 72568; -. [Q8N9N5-6]
DR Antibodypedia; 30702; 164 antibodies from 31 providers.
DR DNASU; 54971; -.
DR Ensembl; ENST00000286122.11; ENSP00000286122.7; ENSG00000172530.21. [Q8N9N5-1]
DR Ensembl; ENST00000355022.8; ENSP00000347125.4; ENSG00000172530.21. [Q8N9N5-2]
DR Ensembl; ENST00000393207.5; ENSP00000376902.1; ENSG00000172530.21. [Q8N9N5-1]
DR Ensembl; ENST00000393208.6; ENSP00000376903.2; ENSG00000172530.21. [Q8N9N5-4]
DR Ensembl; ENST00000479780.6; ENSP00000432508.1; ENSG00000172530.21. [Q8N9N5-6]
DR Ensembl; ENST00000538234.5; ENSP00000444352.1; ENSG00000172530.21. [Q8N9N5-7]
DR Ensembl; ENST00000626016.2; ENSP00000487304.1; ENSG00000172530.21. [Q8N9N5-5]
DR GeneID; 54971; -.
DR KEGG; hsa:54971; -.
DR UCSC; uc002fkp.4; human. [Q8N9N5-1]
DR CTD; 54971; -.
DR DisGeNET; 54971; -.
DR GeneCards; BANP; -.
DR HGNC; HGNC:13450; BANP.
DR HPA; ENSG00000172530; Low tissue specificity.
DR MIM; 611564; gene.
DR neXtProt; NX_Q8N9N5; -.
DR OpenTargets; ENSG00000172530; -.
DR PharmGKB; PA134933411; -.
DR VEuPathDB; HostDB:ENSG00000172530; -.
DR eggNOG; ENOG502QRIF; Eukaryota.
DR GeneTree; ENSGT00390000011116; -.
DR HOGENOM; CLU_037322_0_0_1; -.
DR InParanoid; Q8N9N5; -.
DR OMA; VSREHTK; -.
DR OrthoDB; 1401911at2759; -.
DR PhylomeDB; Q8N9N5; -.
DR TreeFam; TF331908; -.
DR PathwayCommons; Q8N9N5; -.
DR Reactome; R-HSA-6804759; Regulation of TP53 Activity through Association with Co-factors.
DR SignaLink; Q8N9N5; -.
DR SIGNOR; Q8N9N5; -.
DR BioGRID-ORCS; 54971; 611 hits in 1049 CRISPR screens.
DR ChiTaRS; BANP; human.
DR GeneWiki; BANP; -.
DR GenomeRNAi; 54971; -.
DR Pharos; Q8N9N5; Tbio.
DR PRO; PR:Q8N9N5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N9N5; protein.
DR Bgee; ENSG00000172530; Expressed in oocyte and 195 other tissues.
DR ExpressionAtlas; Q8N9N5; baseline and differential.
DR Genevisible; Q8N9N5; HS.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0042177; P:negative regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0034504; P:protein localization to nucleus; IBA:GO_Central.
DR InterPro; IPR042343; BANP.
DR InterPro; IPR018379; BEN_domain.
DR PANTHER; PTHR16243; PTHR16243; 1.
DR Pfam; PF10523; BEN; 1.
DR SMART; SM01025; BEN; 1.
DR PROSITE; PS51457; BEN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell cycle; Chromatin regulator;
KW Coiled coil; Developmental protein; DNA-binding; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Tumor suppressor; Ubl conjugation.
FT CHAIN 1..519
FT /note="Protein BANP"
FT /id="PRO_0000297910"
FT DOMAIN 226..322
FT /note="BEN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT REGION 152..342
FT /note="Interaction with CUX1 and HDAC1"
FT /evidence="ECO:0000250"
FT REGION 168..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..393
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT COILED 53..90
FT /evidence="ECO:0000255"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 100
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 275
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8VBU8"
FT CROSSLNK 133
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027396"
FT VAR_SEQ 24
FT /note="V -> GTELWDI (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043558"
FT VAR_SEQ 25..36
FT /note="VLENHVVTDEDE -> MTREFVKRSIFL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027398"
FT VAR_SEQ 54
FT /note="K -> KSFLYSINQ (in isoform 2, isoform 3, isoform 4,
FT isoform 5, isoform 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027399"
FT VAR_SEQ 114..152
FT /note="Missing (in isoform 2, isoform 3, isoform 4, isoform
FT 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027400"
FT VAR_SEQ 392
FT /note="V -> VIPQ (in isoform 2, isoform 4, isoform 5 and
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027401"
FT VAR_SEQ 425..446
FT /note="Missing (in isoform 2, isoform 3, isoform 6 and
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027402"
FT CONFLICT 123
FT /note="N -> S (in Ref. 1; AK315535)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="P -> S (in Ref. 1; BAA91244)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 519 AA; 56494 MW; 521C53F367A3A29E CRC64;
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKTICLRL
DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS PLGATQTCNK VRCVVPQTTV
ILNNDRQNAI VAKMEDPLSN RAPDSLENVI SNAVPGRRQN TIVVKVPGQE DSHHEDGESG
SEASDSVSSC GQAGSQSIGS NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH
ISTNCRTAEK MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM STPPPASELP
QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV PQGEQVQITQ DSEGNLQIHH
VGQDGQLLEA TRIPCLLAPS VFKASSGQVL QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV
QYVQLAPVSD HTAGAQTAEA LQPTLQPEMQ LEHGAIQIQ
