RS6_CHICK
ID RS6_CHICK Reviewed; 249 AA.
AC P47838;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=40S ribosomal protein S6;
GN Name=RPS6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=7755614; DOI=10.1006/bbrc.1995.1673;
RA Antoine M., Fried M.;
RT "Use of alternative polyadenylation sites by the chicken S6 ribosomal
RT protein gene.";
RL Biochem. Biophys. Res. Commun. 210:384-391(1995).
CC -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC Plays an important role in controlling cell growth and proliferation
CC through the selective translation of particular classes of mRNA (By
CC similarity). {ECO:0000250|UniProtKB:P62753}.
CC -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC eukaryote ribosomes. The phosphorylation is stimulated by growth
CC factors, tumor promoting agents, and mitogens. It is dephosphorylated
CC at growth arrest. {ECO:0000250|UniProtKB:P62753}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC {ECO:0000305}.
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DR EMBL; X81968; CAA57493.1; -; mRNA.
DR PIR; JC4145; JC4145.
DR RefSeq; NP_990556.1; NM_205225.2.
DR AlphaFoldDB; P47838; -.
DR SMR; P47838; -.
DR STRING; 9031.ENSGALP00000024283; -.
DR iPTMnet; P47838; -.
DR PaxDb; P47838; -.
DR GeneID; 396148; -.
DR KEGG; gga:396148; -.
DR CTD; 6194; -.
DR VEuPathDB; HostDB:geneid_396148; -.
DR eggNOG; KOG1646; Eukaryota.
DR InParanoid; P47838; -.
DR OrthoDB; 1326714at2759; -.
DR PhylomeDB; P47838; -.
DR PRO; PR:P47838; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:AgBase.
DR GO; GO:0005634; C:nucleus; ISS:AgBase.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0042593; P:glucose homeostasis; ISS:AgBase.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR InterPro; IPR014401; Ribosomal_S6_euk.
DR InterPro; IPR001377; Ribosomal_S6e.
DR InterPro; IPR018282; Ribosomal_S6e_CS.
DR PANTHER; PTHR11502; PTHR11502; 1.
DR Pfam; PF01092; Ribosomal_S6e; 1.
DR PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR SMART; SM01405; Ribosomal_S6e; 1.
DR PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..249
FT /note="40S ribosomal protein S6"
FT /id="PRO_0000137315"
FT REGION 216..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 240
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 247
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 249 AA; 28654 MW; 39DC4A81BD432ADC CRC64;
MKLNISFPAT GCQKLIEVDD ERNVRTFYEK RMATEVAADS LGEEWKGYVV RISGGNDKQG
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV
TPRVLQHKRR RIALKKQRTQ KNKEEAADYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS
TSKSESSQK
