ID   RS6_DICDI               Reviewed;         236 AA.
AC   Q54UU3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=rps6; ORFNames=DDB_G0280823;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-15; 32-80; 116-136; 144-154; 177-188 AND 203-217, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=AX2;
RA   Bienvenut W.V., Ura S., Insall R.H.;
RL   Submitted (JUL-2009) to UniProtKB.
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000025; EAL67023.1; -; Genomic_DNA.
DR   RefSeq; XP_640998.1; XM_635906.1.
DR   AlphaFoldDB; Q54UU3; -.
DR   SMR; Q54UU3; -.
DR   STRING; 44689.DDB0230023; -.
DR   PaxDb; Q54UU3; -.
DR   EnsemblProtists; EAL67023; EAL67023; DDB_G0280823.
DR   GeneID; 8621805; -.
DR   KEGG; ddi:DDB_G0280823; -.
DR   dictyBase; DDB_G0280823; rps6.
DR   eggNOG; KOG1646; Eukaryota.
DR   HOGENOM; CLU_046346_0_1_1; -.
DR   InParanoid; Q54UU3; -.
DR   OMA; SEFKGYI; -.
DR   PhylomeDB; Q54UU3; -.
DR   Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR   Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DDI-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q54UU3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR   GO; GO:0070938; C:contractile ring; IDA:dictyBase.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISS:dictyBase.
DR   GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR   GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR   GO; GO:0006412; P:translation; ISS:dictyBase.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..236
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000326190"
SQ   SEQUENCE   236 AA;  26166 MW;  0360345CA7731F99 CRC64;
     MKLNIAYPVN GSQKKINIED KNKVRCFMEK RIGQEVEATT LGDEFKGYVF KITGGNDTEG
     FPMMQGVGAP TRVRLLLDGR SGCFKPSRDG ERKRKSVRGC IVAEDIASLQ LIIVKKGDAE
     IPGLTDVSFP ASKGPKRASN IRKLFKLSKD EDVRSFVIRR ELPATDKRKA KSKAPKIQRL
     VTPTTVARRK ALRAKKAARH TKASNEAAEY AKLVAQRQQA KAKRSVKVSS KKVVAK