BAP18_MOUSE
ID BAP18_MOUSE Reviewed; 171 AA.
AC Q9DCT6; Q3TFE6; Q7TMP3; Q9D183;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Chromatin complexes subunit BAP18;
DE AltName: Full=BPTF-associated protein of 18 kDa;
GN Name=Bap18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Embryonic heart, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of chromatin complexes such as the MLL1/MLL and
CC NURF complexes. {ECO:0000250}.
CC -!- SUBUNIT: Component of some MLL1/MLL complex, at least composed of the
CC core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well
CC as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
CC LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2,
CC RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
CC TEX10. Component of the nucleosome-remodeling factor (NURF) complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9DCT6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DCT6-2; Sequence=VSP_021893;
CC Name=3;
CC IsoId=Q9DCT6-3; Sequence=VSP_021892;
CC Name=4;
CC IsoId=Q9DCT6-4; Sequence=VSP_021892, VSP_021893;
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DR EMBL; AK002491; BAB22140.1; -; mRNA.
DR EMBL; AK003842; BAB23031.1; -; mRNA.
DR EMBL; AK169173; BAE40952.1; -; mRNA.
DR EMBL; AK170380; BAE41758.1; -; mRNA.
DR EMBL; AL669869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055357; AAH55357.1; -; mRNA.
DR CCDS; CCDS24940.1; -. [Q9DCT6-3]
DR CCDS; CCDS48832.1; -. [Q9DCT6-4]
DR CCDS; CCDS48833.1; -. [Q9DCT6-2]
DR CCDS; CCDS48835.1; -. [Q9DCT6-1]
DR RefSeq; NP_001171072.1; NM_001177601.1.
DR RefSeq; NP_001171074.1; NM_001177603.1. [Q9DCT6-2]
DR RefSeq; NP_001171077.1; NM_001177606.1. [Q9DCT6-4]
DR RefSeq; NP_001171078.1; NM_001177607.1.
DR RefSeq; NP_081033.1; NM_026757.2. [Q9DCT6-3]
DR RefSeq; NP_665701.1; NM_145758.1. [Q9DCT6-1]
DR AlphaFoldDB; Q9DCT6; -.
DR SMR; Q9DCT6; -.
DR BioGRID; 222642; 3.
DR IntAct; Q9DCT6; 2.
DR MINT; Q9DCT6; -.
DR STRING; 10090.ENSMUSP00000104216; -.
DR iPTMnet; Q9DCT6; -.
DR PhosphoSitePlus; Q9DCT6; -.
DR EPD; Q9DCT6; -.
DR jPOST; Q9DCT6; -.
DR MaxQB; Q9DCT6; -.
DR PaxDb; Q9DCT6; -.
DR PeptideAtlas; Q9DCT6; -.
DR PRIDE; Q9DCT6; -.
DR ProteomicsDB; 277106; -. [Q9DCT6-1]
DR ProteomicsDB; 277108; -. [Q9DCT6-3]
DR DNASU; 104457; -.
DR Ensembl; ENSMUST00000021181; ENSMUSP00000021181; ENSMUSG00000020831. [Q9DCT6-2]
DR Ensembl; ENSMUST00000102569; ENSMUSP00000099629; ENSMUSG00000020831. [Q9DCT6-3]
DR Ensembl; ENSMUST00000108578; ENSMUSP00000104219; ENSMUSG00000020831. [Q9DCT6-1]
DR Ensembl; ENSMUST00000108579; ENSMUSP00000104220; ENSMUSG00000020831. [Q9DCT6-4]
DR GeneID; 104457; -.
DR KEGG; mmu:104457; -.
DR UCSC; uc007jud.2; mouse. [Q9DCT6-2]
DR UCSC; uc007jue.2; mouse. [Q9DCT6-4]
DR UCSC; uc007jug.2; mouse. [Q9DCT6-3]
DR UCSC; uc007juh.2; mouse. [Q9DCT6-1]
DR MGI; MGI:1915609; 0610010K14Rik.
DR VEuPathDB; HostDB:ENSMUSG00000020831; -.
DR eggNOG; KOG4834; Eukaryota.
DR GeneTree; ENSGT00390000014721; -.
DR HOGENOM; CLU_104449_0_0_1; -.
DR InParanoid; Q9DCT6; -.
DR OrthoDB; 1590112at2759; -.
DR PhylomeDB; Q9DCT6; -.
DR BioGRID-ORCS; 104457; 5 hits in 72 CRISPR screens.
DR ChiTaRS; 0610010K14Rik; mouse.
DR PRO; PR:Q9DCT6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DCT6; protein.
DR Bgee; ENSMUSG00000020831; Expressed in embryonic brain and 90 other tissues.
DR ExpressionAtlas; Q9DCT6; baseline and differential.
DR Genevisible; Q9DCT6; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0016589; C:NURF complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR037931; BAP18.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR21397:SF2; PTHR21397:SF2; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromatin regulator; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..171
FT /note="Chromatin complexes subunit BAP18"
FT /id="PRO_0000264252"
FT DOMAIN 38..83
FT /note="SANT"
FT REGION 86..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
FT VAR_SEQ 41..74
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021892"
FT VAR_SEQ 137..171
FT /note="VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA -> SLTLDSGLLTTSA
FT DAPLLSC (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_021893"
SQ SEQUENCE 171 AA; 17996 MW; E7D10D1429D0BABF CRC64;
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD
LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS
SVPEAGVPPI KKQKADVTLS ALNDSDANSD LVDVEGLGET PPAKKLNFDQ A
