ID   RS6_ICTPU               Reviewed;         249 AA.
AC   Q90YR8;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=rps6;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12095691; DOI=10.1016/s0378-1119(02)00595-4;
RA   Karsi A., Patterson A., Feng J., Liu Z.-J.;
RT   "Translational machinery of channel catfish: I. A transcriptomic approach
RT   to the analysis of 32 40S ribosomal protein genes and their expression.";
RL   Gene 291:177-186(2002).
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. The phosphorylation is stimulated by growth
CC       factors, tumor promoting agents, and mitogens. It is dephosphorylated
CC       at growth arrest. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF402814; AAK95188.1; -; mRNA.
DR   RefSeq; NP_001187071.1; NM_001200142.1.
DR   AlphaFoldDB; Q90YR8; -.
DR   SMR; Q90YR8; -.
DR   STRING; 7998.ENSIPUP00000024820; -.
DR   GeneID; 100304560; -.
DR   KEGG; ipu:100304560; -.
DR   CTD; 6194; -.
DR   OMA; FYEKRMS; -.
DR   OrthoDB; 1326714at2759; -.
DR   Proteomes; UP000221080; Chromosome 29.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:AgBase.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0042593; P:glucose homeostasis; ISS:AgBase.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..249
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137316"
FT   REGION          219..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         235
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         236
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         240
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  28736 MW;  BE670BE8FAFC0BCC CRC64;
     MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADP LGDEWKGYVV RISGGNDKQG
     FPMKQGVLTN GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIIRKGEKD
     IPGLTDSTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRR PLTKEGKKPR TKAPKIQRLV
     TPRVLQHKRR RIALKRQRTQ KNKDEAAEYA KLLAKRLKEA KEKRQEKIAK RRRLSSLRAS
     QSKSESSQK