ID   RS6_LEIIN               Reviewed;         249 AA.
AC   O44012;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=RPS6; Synonyms=RS6;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PB75;
RX   PubMed=9703947; DOI=10.1006/bbrc.1998.8927;
RA   Gonzalez-Aseguinolaza G., Taladriz S., Marquet A., Larraga V.;
RT   "Cloning and structural analysis of the gene encoding the ribosomal protein
RT   S6 from the parasite Leishmania infantum.";
RL   Biochem. Biophys. Res. Commun. 248:464-468(1998).
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
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DR   EMBL; AF045457; AAC32260.1; -; mRNA.
DR   PIR; JE0265; JE0265.
DR   PDB; 6AZ1; EM; 2.70 A; G=1-249.
DR   PDBsum; 6AZ1; -.
DR   AlphaFoldDB; O44012; -.
DR   SMR; O44012; -.
DR   STRING; 5671.XP_001465475.1; -.
DR   PRIDE; O44012; -.
DR   VEuPathDB; TriTrypDB:LINF_350025100; -.
DR   eggNOG; KOG1646; Eukaryota.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..249
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137327"
FT   REGION          223..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          2..7
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   TURN            8..10
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          11..15
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   HELIX           20..23
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          24..26
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          36..38
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   HELIX           39..41
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          50..57
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          71..78
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          82..85
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          87..90
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          96..101
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          110..118
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   TURN            126..128
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   HELIX           143..147
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   STRAND          152..154
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   HELIX           185..210
FT                   /evidence="ECO:0007829|PDB:6AZ1"
FT   HELIX           212..237
FT                   /evidence="ECO:0007829|PDB:6AZ1"
SQ   SEQUENCE   249 AA;  28311 MW;  9E020862575AC7CB CRC64;
     MYLNIAYPRN GTVKQFEISD EVLRRVQLQD YRLGNEVDGA IFGSEFKGYI FRLRGGSDKD
     GFPMVPGVLA SSRVSLLVKR GAIGFNTFRG YQGERRRKNV RGCVLASDIA LVNVTISKVG
     DQPIEGVTDT TAPRRLGPKR ASKIRKLFNL SRTEDVRKYV VRRRVVKSGK KDRLKAPKIQ
     RLITPRVKAR RAKKAKDAIA KVRASAAERR EYLRLIASNR RALRQRDHSK KHTQKVHAQR
     AEVAAFQKK