ID   RS6_LEIMA               Reviewed;         249 AA.
AC   Q9NE83; Q4FWR9; Q4QC05;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=RPS6; ORFNames=L3640.11, Lmj_1130, LmjF21.1780, LmjF_21_1780;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
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DR   EMBL; FR796417; CAJ05109.1; -; Genomic_DNA.
DR   RefSeq; XP_001683143.1; XM_001683091.1.
DR   RefSeq; XP_003722593.1; XM_003722545.1.
DR   PDB; 5OSG; EM; 2.90 A; P=1-249.
DR   PDBsum; 5OSG; -.
DR   AlphaFoldDB; Q9NE83; -.
DR   SMR; Q9NE83; -.
DR   STRING; 5664.LmjF.21.1780; -.
DR   EnsemblProtists; CAJ05109; CAJ05109; LMJF_21_1780.
DR   GeneID; 12982497; -.
DR   GeneID; 5651750; -.
DR   KEGG; lma:LMJF_21_1780; -.
DR   KEGG; lma:LMJF_35_2010; -.
DR   VEuPathDB; TriTrypDB:LmjF.21.1780; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_210027300; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_210027500; -.
DR   eggNOG; KOG1646; Eukaryota.
DR   InParanoid; Q9NE83; -.
DR   OMA; SEFKGYI; -.
DR   Proteomes; UP000000542; Chromosome 21.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..249
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137328"
FT   REGION          223..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           218..229
FT                   /evidence="ECO:0007829|PDB:5OSG"
FT   TURN            230..234
FT                   /evidence="ECO:0007829|PDB:5OSG"
FT   HELIX           235..243
FT                   /evidence="ECO:0007829|PDB:5OSG"
FT   TURN            244..248
FT                   /evidence="ECO:0007829|PDB:5OSG"
SQ   SEQUENCE   249 AA;  28304 MW;  E9920868375AC7CF CRC64;
     MKLNIAYPRN GTVKQFEISD EVLRRVQLQD YRLGNEVDGA IFGSEFKGYI FRLRGGSDKD
     GFPMVPGVLA SSRVSLLVKR GAIGFNTFRG YQGERRRKNV RGCVLASDIA LVNVTISKVG
     DQPIEGVTDT TAPRRLGPKR ASKIRKLFNL SRTEDVRKYV VRRRVVKSGK KDRLKAPKIQ
     RLITPRVKAR RAKKAKDAIA KVRASAAERR EYLRLIASNR RALRQRDHSK KHTRKVHAQR
     AEVAAFQKK