BAP29_MOUSE
ID BAP29_MOUSE Reviewed; 240 AA.
AC Q61334;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=B-cell receptor-associated protein 29;
DE Short=BCR-associated protein 29;
DE Short=Bap29;
GN Name=Bcap29; Synonyms=Bap29;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 150-157; 160-177; 179-183;
RP 201-205; 209-216 AND 217-223, AND INTERACTION WITH BCAP31 AND IGD.
RC STRAIN=NIH Swiss; TISSUE=Lymphoid tissue;
RX PubMed=8070407; DOI=10.1002/j.1460-2075.1994.tb06690.x;
RA Kim K.-M., Adachi T., Nielsen P.J., Terashima M., Lamers M.C., Koehler G.,
RA Reth M.;
RT "Two new proteins preferentially associated with membrane immunoglobulin
RT D.";
RL EMBO J. 13:3793-3800(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in anterograde transport of membrane proteins
CC from the endoplasmic reticulum to the Golgi. May be involved in CASP8-
CC mediated apoptosis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and heterodimer with BCAP31. Binds CASP8 as a
CC complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with
CC VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1
CC and non-muscle myosin II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and testis; detected at
CC lower levels in thymus, spleen, liver, lung and bone marrow.
CC -!- SIMILARITY: Belongs to the BCAP29/BCAP31 family. {ECO:0000305}.
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DR EMBL; X78684; CAA55351.1; -; mRNA.
DR EMBL; BC003303; AAH03303.1; -; mRNA.
DR EMBL; BC021661; AAH21661.1; -; mRNA.
DR CCDS; CCDS25864.1; -.
DR PIR; S46997; S46997.
DR RefSeq; NP_001157562.1; NM_001164090.1.
DR RefSeq; NP_031556.1; NM_007530.3.
DR AlphaFoldDB; Q61334; -.
DR SMR; Q61334; -.
DR IntAct; Q61334; 2.
DR MINT; Q61334; -.
DR STRING; 10090.ENSMUSP00000020979; -.
DR iPTMnet; Q61334; -.
DR PhosphoSitePlus; Q61334; -.
DR EPD; Q61334; -.
DR jPOST; Q61334; -.
DR MaxQB; Q61334; -.
DR PaxDb; Q61334; -.
DR PRIDE; Q61334; -.
DR ProteomicsDB; 277161; -.
DR TopDownProteomics; Q61334; -.
DR Antibodypedia; 17207; 297 antibodies from 32 providers.
DR DNASU; 12033; -.
DR Ensembl; ENSMUST00000020979; ENSMUSP00000020979; ENSMUSG00000020650.
DR Ensembl; ENSMUST00000177962; ENSMUSP00000137260; ENSMUSG00000020650.
DR GeneID; 12033; -.
DR KEGG; mmu:12033; -.
DR UCSC; uc007nhp.1; mouse.
DR CTD; 55973; -.
DR MGI; MGI:101917; Bcap29.
DR VEuPathDB; HostDB:ENSMUSG00000020650; -.
DR eggNOG; KOG1962; Eukaryota.
DR GeneTree; ENSGT00390000011863; -.
DR HOGENOM; CLU_070975_1_0_1; -.
DR InParanoid; Q61334; -.
DR OMA; KYSSKEH; -.
DR OrthoDB; 1514108at2759; -.
DR PhylomeDB; Q61334; -.
DR TreeFam; TF315310; -.
DR BioGRID-ORCS; 12033; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Bcap29; mouse.
DR PRO; PR:Q61334; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q61334; protein.
DR Bgee; ENSMUSG00000020650; Expressed in spermatocyte and 261 other tissues.
DR ExpressionAtlas; Q61334; baseline and differential.
DR Genevisible; Q61334; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IGI:MGI.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070973; P:protein localization to endoplasmic reticulum exit site; IGI:MGI.
DR InterPro; IPR008417; BAP29/BAP31.
DR InterPro; IPR040463; BAP29/BAP31_N.
DR InterPro; IPR041672; Bap31/Bap29_C.
DR PANTHER; PTHR12701; PTHR12701; 1.
DR Pfam; PF05529; Bap31; 1.
DR Pfam; PF18035; Bap31_Bap29_C; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Coiled coil; Direct protein sequencing; Endoplasmic reticulum;
KW ER-Golgi transport; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..240
FT /note="B-cell receptor-associated protein 29"
FT /id="PRO_0000142889"
FT TOPO_DOM 1..6
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..103
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT COILED 166..232
FT /evidence="ECO:0000250"
FT MOTIF 237..240
FT /note="Di-lysine motif"
SQ SEQUENCE 240 AA; 27964 MW; 6592492403C4AF1D CRC64;
MTIQWAAVAS FLYAEIGLIL LFCLPFIPPQ RWQKIFSFSV WGKIASFWNK AFLTIIILLI
ILFLDAVREV RKYSSTNVVE KNSAIRPSAF EHTQMKLFRS QRNLYISGFS LFFWLVLRRL
VTLITQLAKE IANKGVLKIQ AENTNKAAKK FMEENEKLKL GLRNDNAEEH LLEAENKKLI
ESKENLKTEL KKASDALLKA QNDVMTMKIQ SERLSKEYDR LLKEHSELQN RLEKEKKKGL
