ID   BAP2_ARATH              Reviewed;         207 AA.
AC   Q58FX0; O80843; Q84N41;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=BON1-associated protein 2;
DE   AltName: Full=Protein BON1-ASSOCIATED PROTEIN 1-LIKE;
GN   Name=BAP2; Synonyms=BAL; OrderedLocusNames=At2g45760; ORFNames=F4I18.26;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION BY PATHOGEN; NEMATODE;
RP   CHEMICALS AND SALT STRESS, INTERACTION WITH BON1; BON2 AND BON3, TISSUE
RP   SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=17631528; DOI=10.1104/pp.107.100800;
RA   Yang H., Yang S., Li Y., Hua J.;
RT   "The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed
RT   cell death.";
RL   Plant Physiol. 145:135-146(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=12481096; DOI=10.1104/pp.010207;
RA   Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT   "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT   of Arabidopsis.";
RL   Plant Physiol. 130:2118-2128(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=11544183; DOI=10.1101/gad.918101;
RA   Hua J., Grisafi P., Cheng S.H., Fink G.R.;
RT   "Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1
RT   genes.";
RL   Genes Dev. 15:2263-2272(2001).
CC   -!- FUNCTION: Negative regulator of cell death and defense responses.
CC       Exhibits calcium-dependent phospholipid binding properties (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:17631528}.
CC   -!- SUBUNIT: Interacts with BON1, BON2 and BON3.
CC       {ECO:0000269|PubMed:17631528}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC       {ECO:0000269|PubMed:17631528}.
CC   -!- INDUCTION: Down-regulated by high temperature. Up-regulated by
CC       salicylic acid, AgNO(3), chitin, cycloheximide, ozone, syringolin, salt
CC       stress and upon pathogen or nematode infection.
CC       {ECO:0000269|PubMed:17631528}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype, but accelerated
CC       hypersensitive response (HR). Bap1 and bap2 double mutant is seedling
CC       lethal. {ECO:0000269|PubMed:17631528}.
CC   -!- MISCELLANEOUS: Overexpression of BAP2 can suppress defects in bap1
CC       mutants.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC28548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC004665; AAC28548.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC10598.1; -; Genomic_DNA.
DR   EMBL; AY954839; AAX55165.1; -; Genomic_DNA.
DR   EMBL; AY262052; AAP22496.1; -; mRNA.
DR   EMBL; BT025263; ABF19016.1; -; mRNA.
DR   PIR; T02471; T02471.
DR   RefSeq; NP_182100.2; NM_130139.3.
DR   AlphaFoldDB; Q58FX0; -.
DR   SMR; Q58FX0; -.
DR   IntAct; Q58FX0; 3.
DR   STRING; 3702.AT2G45760.1; -.
DR   PaxDb; Q58FX0; -.
DR   PRIDE; Q58FX0; -.
DR   EnsemblPlants; AT2G45760.1; AT2G45760.1; AT2G45760.
DR   GeneID; 819184; -.
DR   Gramene; AT2G45760.1; AT2G45760.1; AT2G45760.
DR   KEGG; ath:AT2G45760; -.
DR   Araport; AT2G45760; -.
DR   TAIR; locus:2050782; AT2G45760.
DR   eggNOG; ENOG502SU1K; Eukaryota.
DR   HOGENOM; CLU_088397_1_0_1; -.
DR   InParanoid; Q58FX0; -.
DR   OMA; RVCKLDE; -.
DR   OrthoDB; 1275083at2759; -.
DR   PhylomeDB; Q58FX0; -.
DR   PRO; PR:Q58FX0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q58FX0; baseline and differential.
DR   Genevisible; Q58FX0; AT.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   CDD; cd04051; C2_SRC2_like; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR044750; C2_SRC2/BAP.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Plant defense; Reference proteome.
FT   CHAIN           1..207
FT                   /note="BON1-associated protein 2"
FT                   /id="PRO_0000399506"
FT   DOMAIN          1..112
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ   SEQUENCE   207 AA;  22993 MW;  F25D8FD116990444 CRC64;
     MSYSTFKRSL EIEVISAEGL KVDRKPLKKK TYSVVRIDEK SWASKVDELG GSYPIWKDRF
     DMEMPINASV RFISIEVYYR TSGSGRDKNV GYAKIPVTDF MGGFAPQGHL NFLSYRLRDE
     YGDKCGIVNV SIMVKPDGND HKSSLPSSSF AVAPVDYAAC SWQATAAARN NQMWRPRTSS
     SMVSTAGYGG GRVVTGVPVW CAYQRPS