BAR2_SCHCO
ID BAR2_SCHCO Reviewed; 627 AA.
AC Q05659;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 4.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Pheromone B alpha 2 receptor;
GN Name=BAR2;
OS Schizophyllum commune (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=5334;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=12-43 / FGSC 9297;
RX PubMed=7489716; DOI=10.1002/j.1460-2075.1995.tb00211.x;
RA Wendland J., Vaillancourt L.J., Hegner J., Lengeler K.B., Laddison K.J.,
RA Specht C.A., Raper C.A., Kothe E.;
RT "The mating-type locus B alpha 1 of Schizophyllum commune contains a
RT pheromone receptor gene and putative pheromone genes.";
RL EMBO J. 14:5271-5278(1995).
RN [2]
RP SEQUENCE REVISION, FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22210832; DOI=10.1128/ec.05214-11;
RA Erdmann S., Freihorst D., Raudaskoski M., Schmidt-Heck W., Jung E.M.,
RA Senftleben D., Kothe E.;
RT "Transcriptome and functional analysis: Mating in the basidiomycete
RT Schizophyllum commune.";
RL Eukaryot. Cell 11:571-589(2012).
CC -!- FUNCTION: Receptor for the BAP2 pheromone, a prenylated mating factor.
CC The receptor/pheromone interaction may have a role in the fusion of
CC clamp cells. {ECO:0000269|PubMed:22210832}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22210832};
CC Multi-pass membrane protein {ECO:0000269|PubMed:22210832}.
CC Note=Localizes to the hyphal plasma membrane and is found predominantly
CC in unfused pseudoclamps.
CC -!- INDUCTION: Induced within 6 to 12 hours after mates contact.
CC {ECO:0000269|PubMed:22210832}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 4 family.
CC {ECO:0000305}.
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DR EMBL; X91168; CAA62595.4; -; Genomic_DNA.
DR PIR; S61920; S61920.
DR AlphaFoldDB; Q05659; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004934; F:mating-type alpha-factor pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR InterPro; IPR000481; GPCR_Pheromne_B_alpha_rcpt.
DR InterPro; IPR001499; GPCR_STE3.
DR PANTHER; PTHR28097; PTHR28097; 1.
DR Pfam; PF02076; STE3; 1.
DR PRINTS; PR00899; GPCRSTE3.
DR PRINTS; PR00901; PHEROMONEBAR.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Pheromone response;
KW Receptor; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..627
FT /note="Pheromone B alpha 2 receptor"
FT /id="PRO_0000195071"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..627
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 363..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 68587 MW; 4497EB1C8642E90E CRC64;
MLDPTYPAFP IFAFLGIVCC LVPLPWHLQS WNSGTCFLMI WTAVACLNMF VNSIIWKDHA
QNVAPVWCEI SIRITLGASV GIPASSLCIV RRLYSIAKKF RAVMVDALIC VLFPILYIIL
QIVVQGHRFN ILENIGCFPA IINTPLTYPL TFMWPVLIGV ISFIYSTLAL IQFNRHRLQF
TQFLHSNSTL SVSRYLRLMA LAMTEMMCTT PMGVFVIILN AKATPVSPYV SWAVTHYGYG
RIDQVPAIIW RSNRLLVASY ELTRWSSPAI ALIFFFYFGF AQEARRNYAA AWGWVRRAVG
LPERVPSLPT TKKPFSSSDK GSGFAEKFAA KAKGLSSFNV KDFTSEFTSK AHDFTFKAKQ
YTLPRPMPQT PSSSGFSSSD STRFGSSVDG KELPSPTTKE FSSPIPIHLS GMQTLASFDS
NKDLPSPPAY DVEAQYGPYN IDNRVSYHIA DAGVRASYPM GVAYSSDSEH RRIVPQHSTV
PQHNTADEPA SPALPDTPSS CSSSATFSTL QSRDFIVLPS TTDVTRGTGS LPTRRSPAGP
PRLPSLSQLF GISSMTRERD VEAQVEDVAT GTASPTTTAP APASTTIAPA SATMAPATTT
TAPTTIANIQ RGEPDVPASP RTHRASV
