ID   BAR3_CHITE              Reviewed;        1700 AA.
AC   Q03376;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Balbiani ring protein 3;
DE   Flags: Precursor;
GN   Name=BR3;
OS   Chironomus tentans (Midge) (Camptochironomus tentans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=7153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=1689777; DOI=10.1016/0022-2836(90)90355-p;
RA   Paulsson G., Lendahl U., Galli J., Ericsson C., Wieslander L.;
RT   "The Balbiani ring 3 gene in Chironomus tentans has a diverged repetitive
RT   structure split by many introns.";
RL   J. Mol. Biol. 211:331-349(1990).
CC   -!- FUNCTION: Used by the larvae to construct a supramolecular structure,
CC       the larval tube. Balbiani ring protein 3 could play a role as a
CC       transport protein that binds to other proteins intracellularly and in
CC       the gland lumen in order to prevent these from forming water-insoluble
CC       fibers too early.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Salivary gland.
CC   -!- DOMAIN: Has 82 approximate repeats of Cys-x-Cys-x-cys.
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DR   EMBL; X52263; CAA36506.1; -; mRNA.
DR   PIR; JQ0542; JQ0542.
DR   PIR; S08167; S08167.
DR   AlphaFoldDB; Q03376; -.
DR   PRIDE; Q03376; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004153; CXCXC_repeat.
DR   Pfam; PF03128; CXCXC; 10.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..1700
FT                   /note="Balbiani ring protein 3"
FT                   /id="PRO_0000020792"
SQ   SEQUENCE   1700 AA;  186146 MW;  34202B28521B0815 CRC64;
     MKTLSSLLLV LAVNVLLIQA SPDPDNRCPA RKYWNERKQA CVCKRENRCY PIGAIFDPES
     CTFSMCQSKG CSAKQIFNKD KCACECRNDQ PKDGCGAGRY WCNQDCSCKC STPMSAGGCS
     GSQIWCEKSC ACVCPNADKC TAPQVWNKDT CCCGCPVNMQ EPADGCTKPL IWDKVDCRCE
     CPLKKDCGKN RDWSDSSCSC ECKGDGKCQG SKIWCKNNCR CICPTAEPAG GCSAPLKWDD
     DKCSCACPAK MEEKKEKCVE SGKIWNPNTC ECGCAQLNCP DNKKANKETC QCECKEVKKC
     NGGQVFCKDS CSCVCPGGDK DKTCTAPQVY DGVACSCSCP VNMQKPADGC PRPQKWDKEE
     CRCECPVKHD CKNGKVWDET ICQCICPRDA PVCTAGKERC GESCECKCIN REPKEGCAKP
     LVWNENTCKC VCPADKQMSP GGCGSGKSFN KLTCQCECDQ SASKCGLKRW NADTCKCECQ
     PGMPPEGCGK QTWISDKCKC ECSPTITCQA PQILDLNTCE CKCPVNMLAQ KEKCKSPRQW
     TDSKCLCECS TTPATCEGKQ TWCGEACQCI CPGGDKNCGN KKFFDKPSCE CKCKNNPTCT
     SPQVWDADDC ECKCPKDKQK PQGGCDGGQK WNDRVCSCGC PVPRPDCTNG QIYNINTCAC
     GCGIDKPSCP KQQIYNWKTC DCECPNGMKE PVGGCGAKTW LDDECQCDCV PGKPKGGCTG
     AQKWCDKTCK CKCEKEMPTG GCENNKKWCD ETCDCVCPQK NTCIAPKVWD AKTCSCICVN
     PPKCNSPQVL KDTCCCGCQN VKSCKAPQKF IENICDCACP NKKQCKAPLV WSDEFCDCVC
     PNSASMKTCL SPKEWNKVTC TCDCNPPKPD CCPGTQKWMD DKCKCGCPNA QTDCAGGKKF
     NDFTCSCGCP SGKLDCTGNT KWSAETCTCG CGDVNRNCGN LKNFNDNLCQ CECKNKQEMA
     NCKSPRTWNY DTCKCVCKNA DDSDDCVKPQ IWLDDQCKCG CPASAQMTCP ANKRFIEKSC
     SCECKSPMPS PIPQGKKWNE DKCVVECANV KTCEGPQRWC DNQCKCICPQ VNTKCSDKQK
     FIESKCECGC ETQTQCKDGF RWSNLECGCL CDDKKCPGKQ VFDKNTCQCK CPNQKPGDTC
     GNGKDFCPLD CSCKCKNPKP ANGCTGVQEW NEEKCQCECP KDKPKKQCPG GQDWNNHQCQ
     CGCPTPAPTC SNNQKYSNVS CSCGCNPGKP KNGCPGNQIW CDNTCRCVCP KNMEKPADNC
     KTKWWNDEMC QCVCKPGCPE GGCKGVMKWN ANTCSCECPA DKAKPASCGD KKSWNDDSCS
     CQCKSKMPCG GCPPNQQWNE KDCECKCSAT GNCPAGQTWN SQTCQCSCPA TGKCTGAQVW
     CSKACKCVCP AQKKCDSPKT WDENSCSCQC PKNMRPPTGG CNAGRTWDDA TCSEKCAATP
     KCDSPKVFDP TTCGCKCGNK PNKLDAGRTW DEQKCKMTCD LPAIPCCHYE GQVYDSNTCK
     CGCPKEETCK QGFSFSPKSG CKCILECNKK DPGCGAKKIW CQETCKCECA SEPPRMGCGP
     NRYWDKEDCA CQCLKTKVCT DSDFSFFSHD TCDCECSNAK DFILNCNQKL NKVSCQPQCI
     QRPPPEGCAE KFGEFFSWDP KACECKCIEQ KTTVKGRVFD KATCNFKCTN EPKTNPKCAN
     TAESWDSQIC ACKVCSTCKH