ID   RS6_XENLA               Reviewed;         249 AA.
AC   P39017; Q5D086;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=40S ribosomal protein S6;
GN   Name=rps6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=7513848; DOI=10.1093/nar/21.21.4981;
RA   Odenwald P.W., Jones K.L., Dimario P.J.;
RT   "A complete cDNA sequence for ribosomal protein S6 of Xenopus laevis.";
RL   Nucleic Acids Res. 21:4981-4981(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10231577; DOI=10.1016/s0378-1119(99)00100-6;
RA   Antoine M., Kiefer P.;
RT   "Isolation, characterization and expression of the Xenopus laevis ribosomal
RT   protein S6 gene.";
RL   Gene 231:127-135(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 40S small ribosomal subunit (By similarity).
CC       Plays an important role in controlling cell growth and proliferation
CC       through the selective translation of particular classes of mRNA (By
CC       similarity). {ECO:0000250|UniProtKB:P62753}.
CC   -!- PTM: Ribosomal protein S6 is the major substrate of protein kinases in
CC       eukaryote ribosomes. The phosphorylation is stimulated by growth
CC       factors, tumor promoting agents, and mitogens. It is dephosphorylated
CC       at growth arrest. {ECO:0000250|UniProtKB:P62753}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000305}.
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DR   EMBL; L19996; AAC38014.1; -; mRNA.
DR   EMBL; AF020551; AAD01647.1; -; Genomic_DNA.
DR   EMBL; BC054151; AAH54151.1; -; mRNA.
DR   PIR; S41468; S41468.
DR   RefSeq; NP_001080589.1; NM_001087120.2.
DR   AlphaFoldDB; P39017; -.
DR   SMR; P39017; -.
DR   BioGRID; 98523; 2.
DR   IntAct; P39017; 1.
DR   DNASU; 380281; -.
DR   GeneID; 380281; -.
DR   KEGG; xla:380281; -.
DR   CTD; 380281; -.
DR   Xenbase; XB-GENE-1003294; rps6.S.
DR   OMA; FYEKRMS; -.
DR   OrthoDB; 1326714at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 380281; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR014401; Ribosomal_S6_euk.
DR   InterPro; IPR001377; Ribosomal_S6e.
DR   InterPro; IPR018282; Ribosomal_S6e_CS.
DR   PANTHER; PTHR11502; PTHR11502; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..249
FT                   /note="40S ribosomal protein S6"
FT                   /id="PRO_0000137318"
FT   REGION          161..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         235
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         236
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         240
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  28677 MW;  494C7F04AD91BA3F CRC64;
     MKLNISFPAT GCQKLIEVED ERKLRTFYEK RMATEVAADP LGDEWKGYVV RISGGNDKQG
     FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVRKGEKD
     IPGLTDNTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLAKEGKKPR TKAPKIQRLV
     TPRVLQHKRR RIALKKQRTQ KNKEEASEYA KLLAKRSKEA KEKRQEQIAK RRRLSSLRAS
     TSKSESSQK