BARH1_DROAN
ID BARH1_DROAN Reviewed; 606 AA.
AC P22544; Q23838;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Homeobox protein B-H1;
DE AltName: Full=Homeobox BarH1 protein;
GN Name=B-H1; Synonyms=BarH1, OM(1D);
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Eye-antennal disk;
RX PubMed=1671353; DOI=10.1002/j.1460-2075.1991.tb07962.x;
RA Tanda S., Corces V.G.;
RT "Retrotransposon-induced overexpression of a homeobox gene causes defects
RT in eye morphogenesis in Drosophila.";
RL EMBO J. 10:407-417(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=1674606; DOI=10.1073/pnas.88.10.4343;
RA Saigo K., Emori Y., Sone M., Akimaru H., Takayama E., Higashijima S.,
RA Ishimaru S., Kojima T.;
RT "Identification of a different-type homeobox gene, BarH1, possibly causing
RT Bar (B) and Om(1D) mutations in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:4343-4347(1991).
CC -!- FUNCTION: Functionally required in R1 and R6 receptor cells and primary
CC pigment cells for normal eye development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Abundant in the eye-antenna imaginal disk.
CC {ECO:0000269|PubMed:1671353}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels throughout development,
CC lowest level is in larvae. {ECO:0000269|PubMed:1671353,
CC ECO:0000269|PubMed:1674606}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X56682; CAA40011.1; -; Genomic_DNA.
DR EMBL; M59963; AAA28381.1; -; Genomic_DNA.
DR EMBL; M59962; AAA28381.1; JOINED; Genomic_DNA.
DR PIR; A39369; A39369.
DR PIR; S13367; S13367.
DR AlphaFoldDB; P22544; -.
DR SMR; P22544; -.
DR eggNOG; KOG0488; Eukaryota.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR GO; GO:0008407; P:chaeta morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0008057; P:eye pigment granule organization; IEA:EnsemblMetazoa.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007479; P:leg disc proximal/distal pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0008052; P:sensory organ boundary specification; IEA:EnsemblMetazoa.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Sensory transduction; Vision.
FT CHAIN 1..606
FT /note="Homeobox protein B-H1"
FT /id="PRO_0000049004"
FT DNA_BIND 331..390
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..188
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..583
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 132..133
FT /note="TS -> QG (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="P -> S (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="H -> P (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 285..292
FT /note="GGSAGGGG -> AAARRRR (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="D -> A (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="K -> E (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="S -> R (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="A -> S (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="M -> K (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 450
FT /note="Missing (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 524..527
FT /note="AAAA -> GGGG (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 535
FT /note="I -> S (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
FT CONFLICT 543..549
FT /note="AGSPTGG -> RAAPPAV (in Ref. 2; AAA28381)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 61735 MW; AA7B8B6367370FBB CRC64;
MKDSMSILTQ TPSETPAAHS QLHHHLSHHH HPALHHHPVL QHHYSLQQQH QQQQQQQPPA
PPAVATTTVV NMSGSTTTAA NLKPNRSRFM INDILAGSAA AAFYKQQQQH HHHHHQSHHN
NNNHSGGSSG GTSPTHHNNN NGEGFEPPSG GAGAGAGAAA PPPPLHHLHP QSHPHPHPHP
HSHPHPHALV HPHAKLAAGG GAANGLNVAQ YAAAMQQHYA AAAAAAAARN SAAAAAAAAA
AAASAAAAGG GGGGGLGVGG APAGAELDDS SDYHEENEDC DSDEGGSAGG GGGGSNHMDD
HSVCSNGGKD DDGNSIKSGS TSDMSGLSKK QRKARTAFTD HQLQTLEKSF ERQKYLSVQE
RQELAHKLDL SDCQVKTWYQ NRRTKWMRQT AVGLELLAEA GNFAAFQRLY GGSPYLGAWP
YAAAAGAGAA AAAAHGATPH TSIDIYYRQA AAAAAMQKPL PYNLYAGVPN VGVGVGVGVG
PAPFSHLSAS SSLSSLSSYY QSAAAAAAAA NPGGPPPPPP PSSAAAATGG SPSPIGGLIK
PLAGSPTGGM PPHHPSRPDS ASPPLPLPLA RPPSTPSPTL NPGSPPGRSV DSCSQAQSDD
EDQIQV
