BARH1_MOUSE
ID BARH1_MOUSE Reviewed; 327 AA.
AC P63157; Q9JK26;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=BarH-like 1 homeobox protein;
DE AltName: Full=Bar-class homeodomain protein MBH2;
DE AltName: Full=BarH-related homeobox protein 1;
GN Name=Barhl1; Synonyms=Bhx1, Mbh2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=10814725; DOI=10.1093/hmg/9.9.1443;
RA Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C.,
RA Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.;
RT "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes,
RT is expressed in migrating neurons of the CNS.";
RL Hum. Mol. Genet. 9:1443-1452(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR;
RA Hama T., Saba R., Nakatsuji N., Saito T.;
RT "Identification of a mammalian Bar-class homeobox gene.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RA Toresson H., Campbell K.;
RT "Identification of bhx1, a BarH-related homeobox gene expressed in the
RT developing mouse nervous system.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Exclusively expressed in restricted domains of the
CC developing central nervous system, in particular the diencephalon and
CC rhombencephalon, where it is expressed in migrating cells giving rise
CC to the cerebellar external granular layer and to specific populations
CC of dorsal sensory interneurons of the spinal cord.
CC {ECO:0000269|PubMed:10814725}.
CC -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR EMBL; AJ237590; CAB92529.1; -; mRNA.
DR EMBL; AB043980; BAB18599.1; -; mRNA.
DR EMBL; AF264026; AAK58534.1; -; mRNA.
DR EMBL; BC055731; AAH55731.1; -; mRNA.
DR CCDS; CCDS15849.1; -.
DR RefSeq; NP_001157658.1; NM_001164186.1.
DR RefSeq; NP_062319.1; NM_019446.4.
DR RefSeq; XP_006498245.1; XM_006498182.3.
DR RefSeq; XP_006498246.1; XM_006498183.2.
DR RefSeq; XP_011237440.1; XM_011239138.2.
DR AlphaFoldDB; P63157; -.
DR SMR; P63157; -.
DR BioGRID; 207657; 3.
DR IntAct; P63157; 2.
DR STRING; 10090.ENSMUSP00000053147; -.
DR PhosphoSitePlus; P63157; -.
DR PaxDb; P63157; -.
DR PRIDE; P63157; -.
DR ProteomicsDB; 277178; -.
DR Antibodypedia; 1441; 141 antibodies from 16 providers.
DR DNASU; 54422; -.
DR Ensembl; ENSMUST00000050776; ENSMUSP00000053147; ENSMUSG00000026805.
DR Ensembl; ENSMUST00000113847; ENSMUSP00000109478; ENSMUSG00000026805.
DR Ensembl; ENSMUST00000113849; ENSMUSP00000109480; ENSMUSG00000026805.
DR GeneID; 54422; -.
DR KEGG; mmu:54422; -.
DR UCSC; uc008izh.2; mouse.
DR CTD; 56751; -.
DR MGI; MGI:1859288; Barhl1.
DR VEuPathDB; HostDB:ENSMUSG00000026805; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000160428; -.
DR HOGENOM; CLU_074592_0_0_1; -.
DR InParanoid; P63157; -.
DR OMA; VRMKKPR; -.
DR OrthoDB; 1353352at2759; -.
DR PhylomeDB; P63157; -.
DR TreeFam; TF316128; -.
DR BioGRID-ORCS; 54422; 1 hit in 73 CRISPR screens.
DR PRO; PR:P63157; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P63157; protein.
DR Bgee; ENSMUSG00000026805; Expressed in spinal cord mantle layer and 32 other tissues.
DR Genevisible; P63157; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030901; P:midbrain development; IMP:MGI.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
DR GO; GO:1905586; P:negative regulation of outer hair cell apoptotic process; IMP:MGI.
DR GO; GO:0051402; P:neuron apoptotic process; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:1905584; P:outer hair cell apoptotic process; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..327
FT /note="BarH-like 1 homeobox protein"
FT /id="PRO_0000048827"
FT DNA_BIND 178..237
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 35136 MW; 4130725E55D322FD CRC64;
MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS PASPGRDCLE
TSTSRPGAAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD ILADCKPLAA CAPYSSSGQP
AAPEPGGRLA AKAGEDFRDK LDKSVSSASS DSEYKVKEEG DREISSSRDS PPVRLKKPRK
ARTAFTDHQL AQLERSFERQ KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG
LELLAEAGNY SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
HGLQGASEPP PPLPPLPGVL PRAAQPR
