ID   BARH1_RAT               Reviewed;         327 AA.
AC   P63156; Q9JK26;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=BarH-like 1 homeobox protein;
DE   AltName: Full=Bar-class homeodomain protein MBH2;
DE   AltName: Full=BarH-related homeobox protein 1;
GN   Name=Barhl1; Synonyms=Mbh2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Hama T., Saba R., Nakatsuji N., Saito T.;
RT   "Identification of a mammalian Bar-class homeobox gene.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AB043981; BAB18600.1; -; mRNA.
DR   RefSeq; NP_476450.1; NM_057109.1.
DR   AlphaFoldDB; P63156; -.
DR   SMR; P63156; -.
DR   STRING; 10116.ENSRNOP00000017725; -.
DR   PaxDb; P63156; -.
DR   Ensembl; ENSRNOT00000017725; ENSRNOP00000017725; ENSRNOG00000013209.
DR   GeneID; 117232; -.
DR   KEGG; rno:117232; -.
DR   UCSC; RGD:620648; rat.
DR   CTD; 56751; -.
DR   RGD; 620648; Barhl1.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000160428; -.
DR   HOGENOM; CLU_074592_0_0_1; -.
DR   InParanoid; P63156; -.
DR   OMA; VRMKKPR; -.
DR   OrthoDB; 1353352at2759; -.
DR   PhylomeDB; P63156; -.
DR   TreeFam; TF316128; -.
DR   PRO; PR:P63156; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000013209; Expressed in cerebellum.
DR   Genevisible; P63156; RN.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0030901; P:midbrain development; ISO:RGD.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:1905586; P:negative regulation of outer hair cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; ISO:RGD.
DR   GO; GO:1905584; P:outer hair cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..327
FT                   /note="BarH-like 1 homeobox protein"
FT                   /id="PRO_0000048828"
FT   DNA_BIND        178..237
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..327
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35136 MW;  4130725E55D322FD CRC64;
     MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS PASPGRDCLE
     TSTSRPGAAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD ILADCKPLAA CAPYSSSGQP
     AAPEPGGRLA AKAGEDFRDK LDKSVSSASS DSEYKVKEEG DREISSSRDS PPVRLKKPRK
     ARTAFTDHQL AQLERSFERQ KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG
     LELLAEAGNY SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
     HGLQGASEPP PPLPPLPGVL PRAAQPR