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RS7_BOVIN
ID   RS7_BOVIN               Reviewed;         194 AA.
AC   A6H769;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=40S ribosomal protein S7;
GN   Name=RPS7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for rRNA maturation. {ECO:0000250|UniProtKB:P62081}.
CC   -!- SUBUNIT: Binds IPO9 with high affinity (By similarity). Interacts with
CC       NEK6 (By similarity). Interacts with DESI2 (By similarity). Interacts
CC       with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7
CC       nuclear import for the assembly of ribosomal subunits (By similarity).
CC       {ECO:0000250|UniProtKB:P62081}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:P62081}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P62081}. Nucleus {ECO:0000250|UniProtKB:P62081}.
CC       Note=Although RPS7 is functional within the cytoplasm, the assembly of
CC       ribosomal subunits occurs in the nucleus. RPS7 nuclear import is
CC       mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn
CC       (By similarity). Colocalizes with NEK6 in the centrosome (By
CC       similarity). {ECO:0000250|UniProtKB:P62081}.
CC   -!- PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:P62081}.
CC   -!- PTM: Ubiquitinated. Deubiquitinated by DESI2, leading to its
CC       stabilization. {ECO:0000250|UniProtKB:P62081}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS7 family.
CC       {ECO:0000305}.
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DR   EMBL; BC146133; AAI46134.1; -; mRNA.
DR   RefSeq; NP_001092344.1; NM_001098874.2.
DR   PDB; 6ZVK; EM; 3.49 A; P3=5-193.
DR   PDB; 7A01; EM; 3.60 A; P3=5-193.
DR   PDBsum; 6ZVK; -.
DR   PDBsum; 7A01; -.
DR   AlphaFoldDB; A6H769; -.
DR   SMR; A6H769; -.
DR   STRING; 9913.ENSBTAP00000021587; -.
DR   PaxDb; A6H769; -.
DR   PeptideAtlas; A6H769; -.
DR   PRIDE; A6H769; -.
DR   Ensembl; ENSBTAT00000021587; ENSBTAP00000021587; ENSBTAG00000016224.
DR   GeneID; 505507; -.
DR   KEGG; bta:505507; -.
DR   CTD; 6201; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016224; -.
DR   VGNC; VGNC:34150; RPS7.
DR   eggNOG; KOG3320; Eukaryota.
DR   GeneTree; ENSGT00390000014122; -.
DR   HOGENOM; CLU_088621_1_2_1; -.
DR   InParanoid; A6H769; -.
DR   OMA; AAYHKVQ; -.
DR   OrthoDB; 1289550at2759; -.
DR   TreeFam; TF343364; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000016224; Expressed in ileocecal valve and 106 other tissues.
DR   ExpressionAtlas; A6H769; baseline and differential.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR000554; Ribosomal_S7e.
DR   PANTHER; PTHR11278; PTHR11278; 1.
DR   Pfam; PF01251; Ribosomal_S7e; 1.
DR   PROSITE; PS00948; RIBOSOMAL_S7E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Cytoskeleton; Isopeptide bond;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Ubl conjugation.
FT   CHAIN           1..194
FT                   /note="40S ribosomal protein S7"
FT                   /id="PRO_0000319302"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P62081"
FT   MOD_RES         74
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P62081"
FT   CROSSLNK        70
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P62081"
FT   CROSSLNK        74
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2); alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P62081"
SQ   SEQUENCE   194 AA;  22127 MW;  E21089929CC061E9 CRC64;
     MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI
     IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI LPKPTRKSRT KNKQKRPRSR
     TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL
     TGKDVNFEFP EFQL
 
 
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