RS7_BOVIN
ID RS7_BOVIN Reviewed; 194 AA.
AC A6H769;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=40S ribosomal protein S7;
GN Name=RPS7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for rRNA maturation. {ECO:0000250|UniProtKB:P62081}.
CC -!- SUBUNIT: Binds IPO9 with high affinity (By similarity). Interacts with
CC NEK6 (By similarity). Interacts with DESI2 (By similarity). Interacts
CC with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7
CC nuclear import for the assembly of ribosomal subunits (By similarity).
CC {ECO:0000250|UniProtKB:P62081}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:P62081}. Cytoplasm
CC {ECO:0000250|UniProtKB:P62081}. Nucleus {ECO:0000250|UniProtKB:P62081}.
CC Note=Although RPS7 is functional within the cytoplasm, the assembly of
CC ribosomal subunits occurs in the nucleus. RPS7 nuclear import is
CC mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn
CC (By similarity). Colocalizes with NEK6 in the centrosome (By
CC similarity). {ECO:0000250|UniProtKB:P62081}.
CC -!- PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:P62081}.
CC -!- PTM: Ubiquitinated. Deubiquitinated by DESI2, leading to its
CC stabilization. {ECO:0000250|UniProtKB:P62081}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS7 family.
CC {ECO:0000305}.
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DR EMBL; BC146133; AAI46134.1; -; mRNA.
DR RefSeq; NP_001092344.1; NM_001098874.2.
DR PDB; 6ZVK; EM; 3.49 A; P3=5-193.
DR PDB; 7A01; EM; 3.60 A; P3=5-193.
DR PDBsum; 6ZVK; -.
DR PDBsum; 7A01; -.
DR AlphaFoldDB; A6H769; -.
DR SMR; A6H769; -.
DR STRING; 9913.ENSBTAP00000021587; -.
DR PaxDb; A6H769; -.
DR PeptideAtlas; A6H769; -.
DR PRIDE; A6H769; -.
DR Ensembl; ENSBTAT00000021587; ENSBTAP00000021587; ENSBTAG00000016224.
DR GeneID; 505507; -.
DR KEGG; bta:505507; -.
DR CTD; 6201; -.
DR VEuPathDB; HostDB:ENSBTAG00000016224; -.
DR VGNC; VGNC:34150; RPS7.
DR eggNOG; KOG3320; Eukaryota.
DR GeneTree; ENSGT00390000014122; -.
DR HOGENOM; CLU_088621_1_2_1; -.
DR InParanoid; A6H769; -.
DR OMA; AAYHKVQ; -.
DR OrthoDB; 1289550at2759; -.
DR TreeFam; TF343364; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000016224; Expressed in ileocecal valve and 106 other tissues.
DR ExpressionAtlas; A6H769; baseline and differential.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR InterPro; IPR000554; Ribosomal_S7e.
DR PANTHER; PTHR11278; PTHR11278; 1.
DR Pfam; PF01251; Ribosomal_S7e; 1.
DR PROSITE; PS00948; RIBOSOMAL_S7E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Cytoskeleton; Isopeptide bond;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..194
FT /note="40S ribosomal protein S7"
FT /id="PRO_0000319302"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT MOD_RES 74
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT CROSSLNK 70
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62081"
SQ SEQUENCE 194 AA; 22127 MW; E21089929CC061E9 CRC64;
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI
IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI LPKPTRKSRT KNKQKRPRSR
TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL
TGKDVNFEFP EFQL