BARH2_HUMAN
ID BARH2_HUMAN Reviewed; 387 AA.
AC Q9NY43; A0AVP2; Q7Z4N7;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=BarH-like 2 homeobox protein;
GN Name=BARHL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shan Y.X., Yu L., Huang C.Q., Guo Z.K.;
RT "Cloning and characterization of human novel homeodomain box gene BARHL2.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-364.
RX PubMed=10814725; DOI=10.1093/hmg/9.9.1443;
RA Bulfone A., Menguzzato E., Broccoli V., Marchitiello A., Gattuso C.,
RA Mariani M., Consalez G.G., Martinez S., Ballabio A., Banfi S.;
RT "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes,
RT is expressed in migrating neurons of the CNS.";
RL Hum. Mol. Genet. 9:1443-1452(2000).
CC -!- FUNCTION: Potential regulator of neural basic helix-loop-helix genes.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NY43; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10316571, EBI-742388;
CC Q9NY43; Q04864: REL; NbExp=3; IntAct=EBI-10316571, EBI-307352;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY338397; AAQ01189.1; -; mRNA.
DR EMBL; BC126439; AAI26440.1; -; mRNA.
DR EMBL; BC126441; AAI26442.1; -; mRNA.
DR EMBL; AJ251753; CAB92440.1; -; Genomic_DNA.
DR CCDS; CCDS730.1; -.
DR RefSeq; NP_064447.1; NM_020063.1.
DR AlphaFoldDB; Q9NY43; -.
DR SMR; Q9NY43; -.
DR BioGRID; 131253; 2.
DR IntAct; Q9NY43; 2.
DR STRING; 9606.ENSP00000359474; -.
DR iPTMnet; Q9NY43; -.
DR PhosphoSitePlus; Q9NY43; -.
DR BioMuta; BARHL2; -.
DR DMDM; 47117915; -.
DR jPOST; Q9NY43; -.
DR MassIVE; Q9NY43; -.
DR PaxDb; Q9NY43; -.
DR PeptideAtlas; Q9NY43; -.
DR PRIDE; Q9NY43; -.
DR ProteomicsDB; 83164; -.
DR Antibodypedia; 19858; 81 antibodies from 24 providers.
DR DNASU; 343472; -.
DR Ensembl; ENST00000370445.5; ENSP00000359474.3; ENSG00000143032.8.
DR GeneID; 343472; -.
DR KEGG; hsa:343472; -.
DR MANE-Select; ENST00000370445.5; ENSP00000359474.3; NM_020063.2; NP_064447.1.
DR UCSC; uc001dns.4; human.
DR CTD; 343472; -.
DR DisGeNET; 343472; -.
DR GeneCards; BARHL2; -.
DR HGNC; HGNC:954; BARHL2.
DR HPA; ENSG00000143032; Tissue enriched (brain).
DR MIM; 605212; gene.
DR neXtProt; NX_Q9NY43; -.
DR OpenTargets; ENSG00000143032; -.
DR PharmGKB; PA25258; -.
DR VEuPathDB; HostDB:ENSG00000143032; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000158611; -.
DR HOGENOM; CLU_074592_0_0_1; -.
DR InParanoid; Q9NY43; -.
DR OMA; LDKRDDT; -.
DR OrthoDB; 1353352at2759; -.
DR PhylomeDB; Q9NY43; -.
DR TreeFam; TF316128; -.
DR PathwayCommons; Q9NY43; -.
DR SignaLink; Q9NY43; -.
DR BioGRID-ORCS; 343472; 13 hits in 1091 CRISPR screens.
DR GenomeRNAi; 343472; -.
DR Pharos; Q9NY43; Tbio.
DR PRO; PR:Q9NY43; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NY43; protein.
DR Bgee; ENSG00000143032; Expressed in cerebellum and 18 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..387
FT /note="BarH-like 2 homeobox protein"
FT /id="PRO_0000048829"
FT DNA_BIND 232..291
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 41981 MW; F563EA63489D936D CRC64;
MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS PCSEIDTVGT
APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA PTQSLQPLPQ QQQPLPPQQP
PPPPPQQLGS AASAPRTSTS SFLIKDILGD SKPLAACAPY STSVSSPHHT PKQESNAVHE
SFRPKLEQED SKTKLDKRED SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS
DHQLNQLERS FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE
AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP QLQRPLVPRV
LIHGLGPGGQ PALNPLSSPI PGTPHPR
