BARH2_MOUSE
ID BARH2_MOUSE Reviewed; 384 AA.
AC Q8VIB5; Q66L43;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=BarH-like 2 homeobox protein;
DE AltName: Full=Bar-class homeodomain protein MBH1;
DE AltName: Full=Homeobox protein B-H1;
GN Name=Barhl2; Synonyms=Barh1, Mbh1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-205.
RC STRAIN=129/SvJ; TISSUE=Liver;
RA Saba R., Hama T., Nakatsuji N., Saito T.;
RT "Genomic structure, chromosomal localization, and mouse mammalian Barh1
RT gene.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential regulator of neural basic helix-loop-helix genes.
CC It may down-regulate expression of ASCL1 and, within the thalamus, up-
CC regulate NGN2, thereby regulating distinct patterns of neuronal
CC differentiation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR EMBL; BC078444; AAH78444.1; -; mRNA.
DR EMBL; AB063281; BAB79292.1; -; Genomic_DNA.
DR CCDS; CCDS19497.1; -.
DR RefSeq; NP_001005477.1; NM_001005477.1.
DR AlphaFoldDB; Q8VIB5; -.
DR SMR; Q8VIB5; -.
DR STRING; 10090.ENSMUSP00000084005; -.
DR iPTMnet; Q8VIB5; -.
DR PhosphoSitePlus; Q8VIB5; -.
DR PaxDb; Q8VIB5; -.
DR PRIDE; Q8VIB5; -.
DR ProteomicsDB; 277162; -.
DR Antibodypedia; 19858; 81 antibodies from 24 providers.
DR DNASU; 104382; -.
DR Ensembl; ENSMUST00000086795; ENSMUSP00000084005; ENSMUSG00000034384.
DR GeneID; 104382; -.
DR KEGG; mmu:104382; -.
DR UCSC; uc008ylm.1; mouse.
DR CTD; 343472; -.
DR MGI; MGI:1859314; Barhl2.
DR VEuPathDB; HostDB:ENSMUSG00000034384; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000158611; -.
DR HOGENOM; CLU_074592_0_0_1; -.
DR InParanoid; Q8VIB5; -.
DR OMA; LDKRDDT; -.
DR OrthoDB; 1353352at2759; -.
DR PhylomeDB; Q8VIB5; -.
DR TreeFam; TF316128; -.
DR BioGRID-ORCS; 104382; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Barhl2; mouse.
DR PRO; PR:Q8VIB5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8VIB5; protein.
DR Bgee; ENSMUSG00000034384; Expressed in future spinal cord and 128 other tissues.
DR Genevisible; Q8VIB5; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0035881; P:amacrine cell differentiation; IDA:MGI.
DR GO; GO:0045165; P:cell fate commitment; IDA:MGI.
DR GO; GO:0001709; P:cell fate determination; IMP:MGI.
DR GO; GO:0007399; P:nervous system development; ISO:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045727; P:positive regulation of translation; IMP:MGI.
DR GO; GO:0030516; P:regulation of axon extension; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..384
FT /note="BarH-like 2 homeobox protein"
FT /id="PRO_0000048830"
FT DNA_BIND 229..288
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 41459 MW; 0ECD1F92E8C22B7B CRC64;
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP SPCSEIDTVG
TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HSQQPPPPSA VPAQSLQPSP QQQPPPQPQS
AAQQLGSAAA APRTSTSSFL IKDILGDSKP LAACAPYSTS VSSPHHTPKQ ESNAAHESFR
PKLEQEDGKT KLDKREDPQS DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ
LNQLERSFER QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ RPLVPRVLIH
GLGPGGQPAL NPLSNPIPGT PHPR
