BARH2_RAT
ID BARH2_RAT Reviewed; 384 AA.
AC O88181;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=BarH-like 2 homeobox protein;
DE AltName: Full=Bar-class homeodomain protein MBH1;
DE AltName: Full=Homeobox protein B-H1;
GN Name=Barhl2; Synonyms=Mbh1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Sprague-Dawley; TISSUE=Head;
RX PubMed=9698441; DOI=10.1006/dbio.1998.8889;
RA Saito T., Sawamoto K., Okano H., Anderson D.J., Mikoshiba K.;
RT "Mammalian BarH homologue is a potential regulator of neural bHLH genes.";
RL Dev. Biol. 199:216-225(1998).
CC -!- FUNCTION: Potential regulator of neural basic helix-loop-helix genes.
CC It may down-regulate expression of ASCL1 and, within the thalamus, up-
CC regulate NGN2, thereby regulating distinct patterns of neuronal
CC differentiation. {ECO:0000269|PubMed:9698441}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in the ganglion cell layer of the retina
CC in the eye and in the ventral zone of the dorsal thalamus of the CNS.
CC {ECO:0000269|PubMed:9698441}.
CC -!- DEVELOPMENTAL STAGE: Transiently expressed during embryonic development
CC of the nervous system, detected at 11.5 days old (E11.5) and declining
CC after E15.5. {ECO:0000269|PubMed:9698441}.
CC -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR EMBL; AB004056; BAA32474.1; -; mRNA.
DR RefSeq; NP_075245.1; NM_022956.2.
DR AlphaFoldDB; O88181; -.
DR SMR; O88181; -.
DR STRING; 10116.ENSRNOP00000002887; -.
DR PaxDb; O88181; -.
DR Ensembl; ENSRNOT00000002887; ENSRNOP00000002887; ENSRNOG00000002117.
DR GeneID; 65050; -.
DR KEGG; rno:65050; -.
DR UCSC; RGD:620726; rat.
DR CTD; 343472; -.
DR RGD; 620726; Barhl2.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000158611; -.
DR HOGENOM; CLU_074592_0_0_1; -.
DR InParanoid; O88181; -.
DR OMA; LDKRDDT; -.
DR OrthoDB; 1353352at2759; -.
DR PhylomeDB; O88181; -.
DR TreeFam; TF316128; -.
DR PRO; PR:O88181; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000002117; Expressed in cerebellum.
DR Genevisible; O88181; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0045165; P:cell fate commitment; ISO:RGD.
DR GO; GO:0001709; P:cell fate determination; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; IDA:RGD.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045727; P:positive regulation of translation; ISO:RGD.
DR GO; GO:0030516; P:regulation of axon extension; ISO:RGD.
DR GO; GO:0045664; P:regulation of neuron differentiation; TAS:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..384
FT /note="BarH-like 2 homeobox protein"
FT /id="PRO_0000048831"
FT DNA_BIND 229..288
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 41463 MW; 0C6CB022ECA1F92F CRC64;
MTAMEGASGS SFGIDTILSG AGSGSPGMMN GDFRSLGEAR TTDFRSQATP SPCSEIDTVG
TAPSSPISVT LEPPEPHLVT DGPQHHHHLH HGQQPPPPSA PPAQSLQPSP QQQPPPQPQS
AAQQLGSAAA APRTSTSSFL IKDILGDSKP LAACAPYSTS VSSPHHTPKQ ECNAAHESFR
PKLEQEDSKT KLDKREDSQS DIKCHGTKEE GDREITSSRE SPPVRAKKPR KARTAFSDHQ
LNQLERSFER QKYLSVQDRM DLAAALNLTD TQVKTWYQNR RTKWKRQTAV GLELLAEAGN
YSALQRMFPS PYFYHPSLLG SMDSTTAAAA AAAMYSSMYR TPPAPHPQLQ RPLVPRVLIH
GLGPGGQPAL NPLSNPIPGT PHPR
