ID   BARX1_CHICK             Reviewed;         207 AA.
AC   Q9W6D8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Homeobox protein BarH-like 1;
DE   Flags: Fragment;
GN   Name=BARX1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10213385;
RX   DOI=10.1002/(sici)1097-0177(199904)214:4<291::aid-aja2>3.0.co;2-e;
RA   Barlow A.J., Bogardi J.P., Ladher R., Francis-West P.H.;
RT   "Expression of chick Barx-1 and its differential regulation by FGF-8 and
RT   BMP signaling in the maxillary primordia.";
RL   Dev. Dyn. 214:291-302(1999).
RN   [2]
RP   FUNCTION.
RX   PubMed=10954731; DOI=10.1073/pnas.160245097;
RA   Chen Y., Zhang Y., Jiang T.-X., Barlow A.J., St Amand T.R., Hu Y.,
RA   Heaney S., Francis-West P., Chuong C.-M., Maas R.;
RT   "Conservation of early odontogenic signaling pathways in Aves.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:10044-10049(2000).
CC   -!- FUNCTION: Transcription factor, which is involved in craniofacial
CC       development, in odontogenic region definition, and in stomach
CC       organogenesis. Binds to a regulatory module of the NCAM promoter.
CC       {ECO:0000269|PubMed:10954731}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the facial primordia,
CC       developing stomach, and proximal limbs.
CC   -!- DEVELOPMENTAL STAGE: First detectable in the facial primordia at stage
CC       18 after neural crest migration. Expressed in regions derived from both
CC       mid- and hindbrain neural crest. Also expressed in the developing
CC       cartilage elements of the limb, first within a restricted population in
CC       the prechondrogenic mesenchyme and later in the rounded chondrocytes at
CC       the epiphyses of developing long bones.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AF116460; AAD21043.1; -; mRNA.
DR   AlphaFoldDB; Q9W6D8; -.
DR   BMRB; Q9W6D8; -.
DR   SMR; Q9W6D8; -.
DR   VEuPathDB; HostDB:geneid_374017; -.
DR   InParanoid; Q9W6D8; -.
DR   PhylomeDB; Q9W6D8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..207
FT                   /note="Homeobox protein BarH-like 1"
FT                   /id="PRO_0000048836"
FT   DNA_BIND        95..154
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          157..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   207 AA;  22468 MW;  3EDE64A91D3BCE84 CRC64;
     ANERPPGSCS SSGCRRCCRP GPYHSHLAVL KAEQAAVFKF PLAPLGCSGL GSALLAAGPG
     MPGPAGASHL PLELQLRGKL EAAGSGEPGS KAKKGRRSRT VFTELQLMGL EKRFEKQKYL
     STPDRIDLAE SLGLSQLQVK TWYQNRRMKW KKIVLQGGGL ESPTKPKGRP KKNSIPSSEQ
     LSEQERAKET EKPPESPGEP SERQQEE