ID   BARX1_DANRE             Reviewed;         248 AA.
AC   Q503F2; A3KNS7; Q53B62;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Homeobox protein BarH-like 1;
DE   AltName: Full=BarH-class homeodomain transcription factor 4;
GN   Name=barx1; Synonyms=barh4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kim H.-T., Yoo K.-W., Kim C.-H.;
RT   "Danio rerio barH-class homeodomain transcription factor mRNA.";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor, is involved in craniofacial
CC       development, and in stomach organogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AY596188; AAU00060.1; -; mRNA.
DR   EMBL; BC095353; AAH95353.1; -; mRNA.
DR   EMBL; BC133991; AAI33992.1; -; mRNA.
DR   EMBL; BC162220; AAI62220.1; -; mRNA.
DR   EMBL; BC162228; AAI62228.1; -; mRNA.
DR   RefSeq; NP_001020120.1; NM_001024949.1.
DR   AlphaFoldDB; Q503F2; -.
DR   SMR; Q503F2; -.
DR   STRING; 7955.ENSDARP00000014797; -.
DR   PaxDb; Q503F2; -.
DR   GeneID; 553644; -.
DR   KEGG; dre:553644; -.
DR   CTD; 56033; -.
DR   ZFIN; ZDB-GENE-050522-28; barx1.
DR   eggNOG; KOG0488; Eukaryota.
DR   InParanoid; Q503F2; -.
DR   OrthoDB; 1382174at2759; -.
DR   PhylomeDB; Q503F2; -.
DR   TreeFam; TF350735; -.
DR   PRO; PR:Q503F2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR   GO; GO:0060037; P:pharyngeal system development; IMP:ZFIN.
DR   GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..248
FT                   /note="Homeobox protein BarH-like 1"
FT                   /id="PRO_0000343797"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          197..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        42
FT                   /note="I -> V (in Ref. 2; AAH95353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        105
FT                   /note="V -> G (in Ref. 1; AAU00060)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   248 AA;  27558 MW;  574BC89D4930DB21 CRC64;
     MQHPLEIGAH YYPPDAHLDQ RSHRYRSFMI EEILTDHPDQ KISSPTGDLL KFGVHALLSA
     RPYHNHLVLK ADQTGILKFP VSPLSCSLGA PLSSALLSGA AGLQVGSSSH HLPLDLHLRG
     KLDPGADAVS KTKKGRRSRT VFTELQLMGL EKRFEKQKYL STPDRIDLAE SLGLSQLQVK
     TWYQNRRMKW KKIVLQGGGL ESPTKPKGRP KKNSIPTSEQ LSEQERTREA DRLSDGGASS
     LSDANQEE