BARX1_MOUSE
ID BARX1_MOUSE Reviewed; 254 AA.
AC Q9ER42; O09066; P70159; Q0VF04; Q9ERV2;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Homeobox protein BarH-like 1;
GN Name=Barx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Head;
RA Buchner G.;
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-254.
RC STRAIN=BALB/cJ;
RA Meech R., Edelman D.B., Jones F.S.;
RT "Characterization of the mouse Barx1 gene.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-254.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 108-254, AND DEVELOPMENTAL STAGE.
RC STRAIN=NMRI;
RX PubMed=7669690; DOI=10.1016/0925-4773(94)00343-l;
RA Tissier-Seta J.-P., Mucchielli M.L., Mark M., Mattei M.-G., Goridis C.,
RA Brunet J.-F.;
RT "Barx1, a new mouse homeodomain transcription factor expressed in cranio-
RT facial ectomesenchyme and the stomach.";
RL Mech. Dev. 51:3-15(1995).
RN [5]
RP FUNCTION.
RX PubMed=15809042; DOI=10.1016/j.devcel.2005.01.015;
RA Kim B.-M., Buchner G., Miletich I., Sharpe P.T., Shivdasani R.A.;
RT "The stomach mesenchymal transcription factor Barx1 specifies gastric
RT epithelial identity through inhibition of transient Wnt signaling.";
RL Dev. Cell 8:611-622(2005).
RN [6]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17855428; DOI=10.1242/dev.009308;
RA Kim B.M., Miletich I., Mao J., McMahon A.P., Sharpe P.A., Shivdasani R.A.;
RT "Independent functions and mechanisms for homeobox gene Barx1 in patterning
RT mouse stomach and spleen.";
RL Development 134:3603-3613(2007).
CC -!- FUNCTION: Transcription factor, which is involved in craniofacial
CC development, in odontogenesis and in stomach organogenesis. May have a
CC role in the differentiation of molars from incisors. Plays a role in
CC suppressing endodermal Wnt activity. Binds to a regulatory module of
CC the NCAM promoter. {ECO:0000269|PubMed:15809042,
CC ECO:0000269|PubMed:17855428}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the facial primordia,
CC developing stomach, and proximal limbs.
CC -!- DEVELOPMENTAL STAGE: Expressed in areas of the first and second
CC branchial arches, before any apparent cellular or morphologic
CC differentiation. Later in development, all expressing tissue in this
CC region, including the mesenchyme underlying the olfactory epithelium,
CC the primary and secondary palate, the molar tooth papillae, and the
CC stroma of the submandibular gland, appear to be derived from
CC ectomesenchyme of neural crest origin. By day 16.5, all areas except
CC the developing molars are BARX1-negative. In addition, BARX1 marks the
CC area of the future stomach in the primitive gut at embryonic day 9.5,
CC and is present in the mesenchymal wall of the stomach until embryonic
CC day 16.5. {ECO:0000269|PubMed:17855428, ECO:0000269|PubMed:7669690}.
CC -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR EMBL; AJ297677; CAC10357.1; -; mRNA.
DR EMBL; AF277160; AAG18573.1; -; Genomic_DNA.
DR EMBL; BC119047; AAI19048.2; -; mRNA.
DR EMBL; BC119049; AAI19050.2; -; mRNA.
DR EMBL; Y07960; CAA69257.1; -; mRNA.
DR CCDS; CCDS49258.1; -.
DR RefSeq; NP_031552.2; NM_007526.4.
DR AlphaFoldDB; Q9ER42; -.
DR BMRB; Q9ER42; -.
DR SMR; Q9ER42; -.
DR BioGRID; 198302; 4.
DR IntAct; Q9ER42; 2.
DR STRING; 10090.ENSMUSP00000021813; -.
DR iPTMnet; Q9ER42; -.
DR PhosphoSitePlus; Q9ER42; -.
DR PaxDb; Q9ER42; -.
DR PRIDE; Q9ER42; -.
DR ProteomicsDB; 277179; -.
DR Antibodypedia; 28447; 251 antibodies from 26 providers.
DR DNASU; 12022; -.
DR Ensembl; ENSMUST00000021813; ENSMUSP00000021813; ENSMUSG00000021381.
DR GeneID; 12022; -.
DR KEGG; mmu:12022; -.
DR UCSC; uc007qil.1; mouse.
DR CTD; 56033; -.
DR MGI; MGI:103124; Barx1.
DR VEuPathDB; HostDB:ENSMUSG00000021381; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000160218; -.
DR HOGENOM; CLU_090214_1_0_1; -.
DR InParanoid; Q9ER42; -.
DR OMA; LGAHYYP; -.
DR OrthoDB; 1382174at2759; -.
DR PhylomeDB; Q9ER42; -.
DR TreeFam; TF350735; -.
DR BioGRID-ORCS; 12022; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Barx1; mouse.
DR PRO; PR:Q9ER42; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9ER42; protein.
DR Bgee; ENSMUSG00000021381; Expressed in mandibular prominence and 78 other tissues.
DR Genevisible; Q9ER42; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IMP:MGI.
DR GO; GO:0048513; P:animal organ development; IMP:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0007267; P:cell-cell signaling; IMP:MGI.
DR GO; GO:0055123; P:digestive system development; IMP:MGI.
DR GO; GO:0045446; P:endothelial cell differentiation; IMP:MGI.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048536; P:spleen development; IMP:MGI.
DR GO; GO:0009888; P:tissue development; IMP:MGI.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..254
FT /note="Homeobox protein BarH-like 1"
FT /id="PRO_0000048835"
FT DNA_BIND 142..201
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 27282 MW; 48586B28F4A23FCC CRC64;
MQRPGEPGAA RFGPPEGCAD HRPHRYRSFM IEEILTEPPG PKGAAPAAAA AAAGELLKFG
VQALLAARPF HSHLAVLKAE QAAVFKFPLA PLGCSGLGSA LLAAGPGMPG PAGASHLPLE
LQLRGKLEAA GSGEPGAKAK KGRRSRTVFT ELQLMGLEKR FEKQKYLSTP DRIDLAESLG
LSQLQVKTWY QNRRMKWKKI VLQGGGLESP TKPKGRPKKN SIPTSEQLTE QERAKETEKP
AETPGEPSDR NCED
