ID   BARX2_SHEEP             Reviewed;         133 AA.
AC   Q9N0M2;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Homeobox protein BarH-like 2;
DE   Flags: Fragment;
GN   Name=BARX2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Wool follicle;
RX   PubMed=10998155; DOI=10.1046/j.1523-1747.2000.00122.x;
RA   Sander G., Bawden C.S., Hynd P.I., Nesci A., Rogers G., Powell B.C.;
RT   "Communications: expression of the homeobox gene, barx2, in wool follicle
RT   development.";
RL   J. Invest. Dermatol. 115:753-756(2000).
CC   -!- FUNCTION: Transcription factor. Binds optimally to the DNA consensus
CC       sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural
CC       adhesion molecules such as L1 or Ng-CAM during embryonic development of
CC       both the central and peripherical nervous system. May be involved in
CC       controlling adhesive processes in keratinizing epithelia.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in keratinizing epithelia such as wool
CC       follicle, tongue and esophagus. Expressed at low level in thymus. Not
CC       detected in spleen, skeletal muscle, brain, heart kidney, liver and
CC       lung.
CC   -!- DEVELOPMENTAL STAGE: Uniformly expressed in the embryonic ectoderm but
CC       is transiently down-regulated during the initiation of wool follicle
CC       morphogenesis. Subsequently expressed throughout the epithelial
CC       component of the developing follicle except for a small group of cells
CC       at the leading edge of the follicle placode. In adult follicles,
CC       expressed throughout the outer root sheath but not in the inner root
CC       sheath or hair shaft, or in dermal cells associated with the follicle.
CC   -!- SIMILARITY: Belongs to the BAR homeobox family. {ECO:0000305}.
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DR   EMBL; AF265552; AAF73466.1; -; mRNA.
DR   AlphaFoldDB; Q9N0M2; -.
DR   SMR; Q9N0M2; -.
DR   STRING; 9940.ENSOARP00000014523; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..133
FT                   /note="Homeobox protein BarH-like 2"
FT                   /id="PRO_0000048840"
FT   DNA_BIND        <1..46
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          45..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   133 AA;  14979 MW;  F9E6F017E8819714 CRC64;
     ELEKEFQKQK YLSTPDRLDL AQSLGLTQLQ VKTWYQNRRM KWKKMVLKGG QEAPTKPKGR
     PKKNSIPTSE EIEAEEKLNS QVQSQELREP SQGLEGLCDT QEPKARVVPV EVAESPGQAQ
     ELPVTSPEPP PSS