RS7_MOUSE
ID RS7_MOUSE Reviewed; 194 AA.
AC P62082; P23821; P24818;
DT 21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=40S ribosomal protein S7;
GN Name=Rps7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=9801797; DOI=10.1080/15216549800203802;
RA Annilo T., Jelina J., Pata I., Metspalu A.;
RT "Isolation and characterization of the mouse ribosomal protein S7 gene.";
RL Biochem. Mol. Biol. Int. 46:287-295(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for rRNA maturation. {ECO:0000250|UniProtKB:P62081}.
CC -!- SUBUNIT: Binds IPO9 with high affinity (By similarity). Interacts with
CC NEK6 (By similarity). Interacts with DESI2 (By similarity). Interacts
CC with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7
CC nuclear import for the assembly of ribosomal subunits (By similarity).
CC {ECO:0000250|UniProtKB:P62081}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:P62081}. Cytoplasm
CC {ECO:0000250|UniProtKB:P62081}. Nucleus {ECO:0000250|UniProtKB:P62081}.
CC Note=Although RPS7 is functional within the cytoplasm, the assembly of
CC ribosomal subunits occurs in the nucleus. RPS7 nuclear import is
CC mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn
CC (By similarity). Colocalizes with NEK6 in the centrosome (By
CC similarity). {ECO:0000250|UniProtKB:P62081}.
CC -!- PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:P62081}.
CC -!- PTM: Ubiquitinated. Deubiquitinated by DESI2, leading to its
CC stabilization. {ECO:0000250|UniProtKB:P62081}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS7 family.
CC {ECO:0000305}.
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DR EMBL; AF043285; AAB97861.1; -; Genomic_DNA.
DR EMBL; BC002014; AAH02014.1; -; mRNA.
DR CCDS; CCDS25851.1; -.
DR RefSeq; NP_035430.1; NM_011300.3.
DR PDB; 7CPU; EM; 2.82 A; SH=1-194.
DR PDB; 7CPV; EM; 3.03 A; SH=1-194.
DR PDB; 7LS1; EM; 3.30 A; t=1-194.
DR PDB; 7LS2; EM; 3.10 A; t=1-194.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P62082; -.
DR SMR; P62082; -.
DR BioGRID; 203016; 82.
DR ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR IntAct; P62082; 6.
DR MINT; P62082; -.
DR STRING; 10090.ENSMUSP00000073880; -.
DR iPTMnet; P62082; -.
DR PhosphoSitePlus; P62082; -.
DR SwissPalm; P62082; -.
DR EPD; P62082; -.
DR jPOST; P62082; -.
DR PaxDb; P62082; -.
DR PeptideAtlas; P62082; -.
DR PRIDE; P62082; -.
DR ProteomicsDB; 262735; -.
DR TopDownProteomics; P62082; -.
DR Antibodypedia; 26343; 189 antibodies from 28 providers.
DR DNASU; 20115; -.
DR Ensembl; ENSMUST00000074267; ENSMUSP00000073880; ENSMUSG00000061477.
DR Ensembl; ENSMUST00000221871; ENSMUSP00000152456; ENSMUSG00000061477.
DR GeneID; 20115; -.
DR KEGG; mmu:20115; -.
DR UCSC; uc007nfs.2; mouse.
DR CTD; 6201; -.
DR MGI; MGI:1333818; Rps7.
DR VEuPathDB; HostDB:ENSMUSG00000061477; -.
DR eggNOG; KOG3320; Eukaryota.
DR GeneTree; ENSGT00390000014122; -.
DR HOGENOM; CLU_088621_1_2_1; -.
DR InParanoid; P62082; -.
DR OMA; AAYHKVQ; -.
DR OrthoDB; 1289550at2759; -.
DR PhylomeDB; P62082; -.
DR TreeFam; TF343364; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72649; Translation initiation complex formation.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 20115; 26 hits in 76 CRISPR screens.
DR ChiTaRS; Rps7; mouse.
DR PRO; PR:P62082; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P62082; protein.
DR Bgee; ENSMUSG00000061477; Expressed in cortical plate and 66 other tissues.
DR ExpressionAtlas; P62082; baseline and differential.
DR Genevisible; P62082; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IDA:SynGO.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; ISO:MGI.
DR GO; GO:0048027; F:mRNA 5'-UTR binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR GO; GO:1904667; P:negative regulation of ubiquitin protein ligase activity; ISO:MGI.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0014033; P:neural crest cell differentiation; IMP:MGI.
DR GO; GO:0001843; P:neural tube closure; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; ISO:MGI.
DR InterPro; IPR000554; Ribosomal_S7e.
DR PANTHER; PTHR11278; PTHR11278; 1.
DR Pfam; PF01251; Ribosomal_S7e; 1.
DR PROSITE; PS00948; RIBOSOMAL_S7E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Cytoskeleton; Isopeptide bond;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..194
FT /note="40S ribosomal protein S7"
FT /id="PRO_0000174191"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT MOD_RES 74
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT CROSSLNK 70
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62081"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62081"
SQ SEQUENCE 194 AA; 22127 MW; E21089929CC061E9 CRC64;
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI
IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI LPKPTRKSRT KNKQKRPRSR
TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL
TGKDVNFEFP EFQL
