BASP1_BOVIN
ID BASP1_BOVIN Reviewed; 227 AA.
AC P80724; O02692; Q08E19;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Brain acid soluble protein 1;
DE AltName: Full=22 kDa neuronal tissue-enriched acidic protein;
DE AltName: Full=Neuronal axonal membrane protein NAP-22;
GN Name=BASP1; Synonyms=NAP22;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9749536;
RA Park S., Kim Y.-I., Kim B., Seong C., Oh Y., Baek K., Yoon J.;
RT "Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa
RT neuronal tissue-enriched acidic protein) homologs.";
RL Mol. Cells 8:471-477(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 2-227, AND MYRISTOYLATION AT GLY-2.
RC TISSUE=Brain;
RX PubMed=9310187; DOI=10.1016/s0300-9084(97)80032-6;
RA Mosevitsky M.I., Capony J.-P., Skladchikova G.Y.U., Novitskaya V.A.,
RA Plekhanov A.Y.U., Zakharov V.V.;
RT "The BASP1 family of myristoylated proteins abundant in axonal termini.
RT Primary structure analysis and physico-chemical properties.";
RL Biochimie 79:373-384(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Cell projection,
CC growth cone. Note=Associated with the membranes of growth cones that
CC form the tips of elongating axons.
CC -!- TISSUE SPECIFICITY: Brain.
CC -!- SIMILARITY: Belongs to the BASP1 family. {ECO:0000305}.
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DR EMBL; U92535; AAC67307.1; -; mRNA.
DR EMBL; BC123462; AAI23463.1; -; mRNA.
DR RefSeq; NP_777205.1; NM_174780.3.
DR AlphaFoldDB; P80724; -.
DR iPTMnet; P80724; -.
DR PeptideAtlas; P80724; -.
DR PRIDE; P80724; -.
DR Ensembl; ENSBTAT00000078276; ENSBTAP00000056785; ENSBTAG00000048565.
DR GeneID; 286842; -.
DR KEGG; bta:286842; -.
DR CTD; 10409; -.
DR VEuPathDB; HostDB:ENSBTAG00000048565; -.
DR VGNC; VGNC:106649; BASP1.
DR GeneTree; ENSGT00730000111450; -.
DR InParanoid; P80724; -.
DR OMA; QLKRGFK; -.
DR OrthoDB; 1607515at2759; -.
DR Proteomes; UP000009136; Chromosome 20.
DR Bgee; ENSBTAG00000048565; Expressed in Ammon's horn and 106 other tissues.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR008408; BASP1.
DR PANTHER; PTHR23212; PTHR23212; 1.
DR Pfam; PF05466; BASP1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Direct protein sequencing; Isopeptide bond;
KW Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9310187"
FT CHAIN 2..227
FT /note="Brain acid soluble protein 1"
FT /id="PRO_0000142894"
FT REGION 1..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 36
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 170
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 172
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91XV3"
FT MOD_RES 196
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:9310187"
FT CROSSLNK 25
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT CROSSLNK 87
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT CROSSLNK 99
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P80723"
FT CROSSLNK 163
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P80723"
SQ SEQUENCE 227 AA; 23011 MW; 44DB3207A6FC768E CRC64;
MGGKLSKKKK GYNVNDEKAK DKDKKAEGAG TEEEGTPKEN EAQAAAETPE VKEGKEEKPE
KDAQDTTKPE DKEGEKDAEA AKEDAPKAEP EPTEGAEGKP EPPKDAEQEP AAASGPSTGG
DAPKASEAEA AEPAAPTKDD KSKEGGDATK TEAPAAPAAQ ETKSDGAPAS DSKPSSTEAA
PSSKETPAAT EAPSSTPKAQ APAAPADEVK PAETPAANSD QTVAVKE
