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BASR_EMENI
ID   BASR_EMENI              Reviewed;         305 AA.
AC   A0A1U8QVN4; C8VD49; Q5AX06;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Myb-like transcriptional regulator basR {ECO:0000303|PubMed:30311911};
GN   Name=basR {ECO:0000303|PubMed:30311911}; ORFNames=AN7174;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=30311911; DOI=10.7554/elife.40969;
RA   Fischer J., Mueller S.Y., Netzker T., Jaeger N., Gacek-Matthews A.,
RA   Scherlach K., Stroe M.C., Garcia-Altares M., Pezzini F., Schoeler H.,
RA   Reichelt M., Gershenzon J., Krespach M.K., Shelest E., Schroeckh V.,
RA   Valiante V., Heinzel T., Hertweck C., Strauss J., Brakhage A.A.;
RT   "Chromatin mapping identifies BasR, a key regulator of bacteria-triggered
RT   production of fungal secondary metabolites.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Transcription regulator that acts as a central regulatory
CC       node for the integration of external bacterial signals leading to the
CC       regulation of secondary metabolite gene clusters such as orsellinic,
CC       lecanoric acid, cichorine, 2,4-dihydroxy-3-methyl-6-(2-
CC       oxopropyl)benzaldehyde (dba), emericellamide or microperfuranone
CC       clusters. {ECO:0000269|PubMed:30311911}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:30311911}.
CC   -!- INDUCTION: Expression is induced during co-cultivation with
CC       Streptomyces rapamycinicus. {ECO:0000269|PubMed:30311911}.
CC   -!- DISRUPTION PHENOTYPE: Results in a significantly reduced expression of
CC       orsA and orsD, and in complete loss of orsellinic acid production,
CC       during response to Streptomyces rapamycinicus.
CC       {ECO:0000269|PubMed:30311911}.
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DR   EMBL; BN001304; CBF78928.1; -; Genomic_DNA.
DR   EMBL; AACD01000122; EAA61426.1; -; Genomic_DNA.
DR   RefSeq; XP_664778.1; XM_659686.1.
DR   SMR; A0A1U8QVN4; -.
DR   STRING; 162425.CADANIAP00000281; -.
DR   EnsemblFungi; CBF78928; CBF78928; ANIA_07174.
DR   EnsemblFungi; EAA61426; EAA61426; AN7174.2.
DR   GeneID; 2869822; -.
DR   KEGG; ani:AN7174.2; -.
DR   VEuPathDB; FungiDB:AN7174; -.
DR   eggNOG; KOG0048; Eukaryota.
DR   HOGENOM; CLU_912241_0_0_1; -.
DR   OMA; YITIHGP; -.
DR   OrthoDB; 1499244at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd00167; SANT; 3.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 3.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51294; HTH_MYB; 2.
DR   PROSITE; PS50090; MYB_LIKE; 3.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..305
FT                   /note="Myb-like transcriptional regulator basR"
FT                   /id="PRO_0000454890"
FT   DOMAIN          5..59
FT                   /note="Myb-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DOMAIN          60..110
FT                   /note="Myb-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DOMAIN          111..162
FT                   /note="Myb-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   REGION          175..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   305 AA;  35020 MW;  4DE210B99E39BBFA CRC64;
     MTEPRRRWTA AEDALLWDLY QVQEKAPTGK CQKINWNEIA RHIPGRTNKD CRKRYYNRFT
     GGLRKGSWTQ EEDERLFRLV ERYQYRWATI AQKMETRNAD QCSKRWHHCL NPELERSPWT
     VDENMLLLSA VNTHGSSWKD IQKCHFPTRS ANNIKNQYTI LSRKNISLAP AHLHPCCDSP
     SPSKSSRRPP STPTSTPQVP GSRQGSSYDP YDYGSLSSTP QLSATDYLPA TPEAPAVNFD
     MAMGAFGDSC GYMPQYQPSP SFYANSPDGS ELMMPETMGM RMRYDFRDGL EQEGVRYPGQ
     ETFGY
 
 
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