ID   BAT15_CAEEL             Reviewed;         273 AA.
AC   P34324;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=BTB and MATH domain-containing protein 15;
DE   Flags: Fragment;
GN   Name=bath-15; ORFNames=C08C3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
RX   PubMed=13679922; DOI=10.1038/nature01985;
RA   Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J.,
RA   Harper J.W.;
RT   "BTB proteins are substrate-specific adaptors in an SCF-like modular
RT   ubiquitin ligase containing CUL-3.";
RL   Nature 425:316-321(2003).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins.
CC       {ECO:0000269|PubMed:13679922}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with cul-3. {ECO:0000269|PubMed:13679922}.
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DR   EMBL; FO080429; CCD63644.1; -; Genomic_DNA.
DR   PIR; S44616; S44616.
DR   RefSeq; NP_498694.2; NM_066293.4.
DR   AlphaFoldDB; P34324; -.
DR   SMR; P34324; -.
DR   BioGRID; 47245; 6.
DR   IntAct; P34324; 1.
DR   STRING; 6239.C08C3.2; -.
DR   PaxDb; P34324; -.
DR   EnsemblMetazoa; C08C3.2a.1; C08C3.2a.1; WBGene00015590.
DR   GeneID; 182393; -.
DR   KEGG; cel:CELE_C08C3.2; -.
DR   UCSC; C08C3.2; c. elegans.
DR   CTD; 182393; -.
DR   WormBase; C08C3.2a; CE39087; WBGene00015590; bath-15.
DR   eggNOG; ENOG502RXUT; Eukaryota.
DR   GeneTree; ENSGT00390000016595; -.
DR   HOGENOM; CLU_051249_1_0_1; -.
DR   InParanoid; P34324; -.
DR   PhylomeDB; P34324; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015590; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; P34324; baseline and differential.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR008974; TRAF-like.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00917; MATH; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00061; MATH; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS50144; MATH; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..>273
FT                   /note="BTB and MATH domain-containing protein 15"
FT                   /id="PRO_0000065167"
FT   DOMAIN          7..123
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   DOMAIN          147..206
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   NON_TER         273
SQ   SEQUENCE   273 AA;  31274 MW;  F5F2F1457B77C5E1 CRC64;
     MVAASKEFVF HHTFKDVSQL EDGDFFKSPE EIHYNAEWFI LVIRTKDQLE AYLHCDNEKD
     DNVAWTVDAE FSLKIASSSG SYAMKFQKGC FDGFGLGWND FVSWDSLTED FLYDNSFTIE
     ACVKITKMTG FSKDVLRSFD ESEKRFSDVI LVVGDEKFYV LKLFLASHSS YFNALFLGKF
     KEADQSEVTL QNIDPTDFQS LLEVLYGEPA IDDGTIDGVL LLAHMLDVTL AIRKCEEFLI
     EKSMKSMREL LKMANQYQLE NLKTVCISKI NTI