ID   BAT40_CAEEL             Reviewed;         402 AA.
AC   Q9NF14;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=BTB and MATH domain-containing protein 40;
GN   Name=bath-40; ORFNames=Y105E8B.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
RX   PubMed=13679922; DOI=10.1038/nature01985;
RA   Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J.,
RA   Harper J.W.;
RT   "BTB proteins are substrate-specific adaptors in an SCF-like modular
RT   ubiquitin ligase containing CUL-3.";
RL   Nature 425:316-321(2003).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins.
CC       {ECO:0000269|PubMed:13679922}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with cul-3. {ECO:0000269|PubMed:13679922}.
CC   -!- INTERACTION:
CC       Q9NF14; Q17391: cul-3; NbExp=2; IntAct=EBI-313743, EBI-593075;
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DR   EMBL; AL132877; CAB60850.1; -; Genomic_DNA.
DR   RefSeq; NP_493543.1; NM_061142.5.
DR   AlphaFoldDB; Q9NF14; -.
DR   SMR; Q9NF14; -.
DR   BioGRID; 38706; 6.
DR   DIP; DIP-25100N; -.
DR   IntAct; Q9NF14; 7.
DR   STRING; 6239.Y105E8B.4; -.
DR   EPD; Q9NF14; -.
DR   PaxDb; Q9NF14; -.
DR   PeptideAtlas; Q9NF14; -.
DR   EnsemblMetazoa; Y105E8B.4.1; Y105E8B.4.1; WBGene00013689.
DR   GeneID; 173321; -.
DR   KEGG; cel:CELE_Y105E8B.4; -.
DR   UCSC; Y105E8B.4; c. elegans.
DR   CTD; 173321; -.
DR   WormBase; Y105E8B.4; CE24096; WBGene00013689; bath-40.
DR   eggNOG; KOG1987; Eukaryota.
DR   HOGENOM; CLU_056825_0_0_1; -.
DR   InParanoid; Q9NF14; -.
DR   OMA; AEYRFYF; -.
DR   OrthoDB; 864323at2759; -.
DR   PhylomeDB; Q9NF14; -.
DR   Reactome; R-CEL-5632684; Hedgehog 'on' state.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9NF14; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00013689; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR008974; TRAF-like.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS50144; MATH; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..402
FT                   /note="BTB and MATH domain-containing protein 40"
FT                   /id="PRO_0000246701"
FT   DOMAIN          43..177
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   DOMAIN          222..295
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  45550 MW;  0C181814BC97C115 CRC64;
     MSDRHLYGSD HSYLSSKPSC SSCRRQSSTS QKNECMTNPG SIVLTQRWTV CNFESLLKLS
     RPGSCLRSTV FKDDAVPDAC WQLCLYPGGK REENANNVSL FLKMSATSPS KEVVLKAEYR
     FYFLDDNDEP KFSNVNVGEF HAKPPKGGHS WGLRNIPTQK VQNSIRQDKS LVISCHIELI
     PDASKVPCKR VPITPSIEMP FAQIPRAHVE SELEMLASGD GTDMTIVAGP LDGEREQFRV
     HAYKLRAHSD VFQMMLSHTE MRENQEKRIE ILDFSPTSVR AMVEFIYAGV IKSDIDVYQA
     VDVMQIAEKY QILALKMTCE QHLLDRLNVN NVLECITHAE RYNTDVLYDA CVDFAIHNRQ
     HVMALTSWRN FISDEPVLAS NLLEKMVKSN DNSSPPVKKP RV