BAT42_CAEEL
ID BAT42_CAEEL Reviewed; 410 AA.
AC P34371;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=BTB and MATH domain-containing protein 42;
GN Name=bath-42; ORFNames=C50C3.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
RX PubMed=13679922; DOI=10.1038/nature01985;
RA Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J.,
RA Harper J.W.;
RT "BTB proteins are substrate-specific adaptors in an SCF-like modular
RT ubiquitin ligase containing CUL-3.";
RL Nature 425:316-321(2003).
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins.
CC {ECO:0000269|PubMed:13679922}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with cul-3. {ECO:0000269|PubMed:13679922}.
CC -!- INTERACTION:
CC P34371; Q17391: cul-3; NbExp=3; IntAct=EBI-315422, EBI-593075;
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DR EMBL; FO080718; CCD66124.1; -; Genomic_DNA.
DR PIR; S44626; S44626.
DR RefSeq; NP_498784.1; NM_066383.3.
DR AlphaFoldDB; P34371; -.
DR SMR; P34371; -.
DR BioGRID; 41357; 14.
DR DIP; DIP-26215N; -.
DR IntAct; P34371; 7.
DR STRING; 6239.C50C3.8; -.
DR EPD; P34371; -.
DR PaxDb; P34371; -.
DR PeptideAtlas; P34371; -.
DR EnsemblMetazoa; C50C3.8.1; C50C3.8.1; WBGene00016803.
DR GeneID; 176152; -.
DR KEGG; cel:CELE_C50C3.8; -.
DR UCSC; C50C3.8.1; c. elegans.
DR CTD; 176152; -.
DR WormBase; C50C3.8; CE00124; WBGene00016803; bath-42.
DR eggNOG; KOG1987; Eukaryota.
DR GeneTree; ENSGT00990000209887; -.
DR HOGENOM; CLU_056825_0_0_1; -.
DR InParanoid; P34371; -.
DR OMA; TLFLICE; -.
DR OrthoDB; 864323at2759; -.
DR PhylomeDB; P34371; -.
DR Reactome; R-CEL-5632684; Hedgehog 'on' state.
DR UniPathway; UPA00143; -.
DR PRO; PR:P34371; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016803; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..410
FT /note="BTB and MATH domain-containing protein 42"
FT /id="PRO_0000065254"
FT DOMAIN 45..173
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT DOMAIN 219..287
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46714 MW; ED0E2ED32A0CDA3C CRC64;
MSSRSSWSST EQINRTISSR ADDLPPQPRR LEVVSKQATR VTALSTKLEW KIEQFEKLMK
LIKNGSNLIS RMFSVPDAPT VCWELHVYPN GKRDEDVNNV SFFLRQVGLA RGEEPIMTEF
QIYALDANNQ RVSVCRDTKD FTNQQGRGKF QVSRDKMLGA LRSDGTLFLI CEVEYFPPGS
KISVEPVVDE DVSTEEQEEM PEVIVRANNR SMWEDELFTD CVIHVGNKHI KAHRCILGQN
SPVFKSMFSS PNMIEAQKGE IHIEDAKYDS VRAMVEFMYT GATESLESQG NIDEILAIAD
KYEVLMLKDQ CERLIAQTIN LKNVTQIAMF SDTYTADYLK SAVIRFLTTH HRVVIKTQDW
ISLKKSRHEL ANELLEAVLS TDQDDDDVTS NIPISVSPPP ARKRLRRSAK
