BATF2_HUMAN
ID BATF2_HUMAN Reviewed; 274 AA.
AC Q8N1L9; D9IC56; Q8NAF4; Q8NAL8; Q96EH4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Basic leucine zipper transcriptional factor ATF-like 2;
DE Short=B-ATF-2;
DE AltName: Full=Suppressor of AP-1 regulated by IFN;
DE Short=SARI;
GN Name=BATF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
RX PubMed=19074269; DOI=10.1073/pnas.0807975106;
RA Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D.,
RA Fisher P.B.;
RT "Cloning and characterization of SARI (suppressor of AP-1, regulated by
RT IFN).";
RL Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Pericardium, Placenta, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=20531301; DOI=10.1038/onc.2010.194;
RA Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.;
RT "Inhibition of AP-1 by SARI negatively regulates transformation progression
RT mediated by CCN1.";
RL Oncogene 29:4412-4423(2010).
RN [6]
RP INDUCTION.
RX PubMed=20473897; DOI=10.1002/ijc.25407;
RA Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J.,
RA Li J., Chen M., Xia J.;
RT "Decreased expression of BATF2 is associated with a poor prognosis in
RT hepatocellular carcinoma.";
RL Int. J. Cancer 128:771-777(2011).
CC -!- FUNCTION: AP-1 family transcription factor that controls the
CC differentiation of lineage-specific cells in the immune system.
CC Following infection, participates in the differentiation of CD8(+)
CC thymic conventional dendritic cells in the immune system. Acts via the
CC formation of a heterodimer with JUN family proteins that recognizes and
CC binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target
CC genes (By similarity). Selectively suppresses CCN1 transcription and
CC hence blocks the downstream cell proliferation signals produced by CCN1
CC and inhibits CCN1-induced anchorage-independent growth and invasion in
CC several cancer types, such as breast cancer, malignant glioma and
CC metastatic melanoma. Possibly acts by interfering with AP-1 binding to
CC CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with JUN family proteins.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N1L9; P49715: CEBPA; NbExp=2; IntAct=EBI-742695, EBI-1172054;
CC Q8N1L9; P53567: CEBPG; NbExp=2; IntAct=EBI-742695, EBI-740209;
CC Q8N1L9; Q15038: DAZAP2; NbExp=3; IntAct=EBI-742695, EBI-724310;
CC Q8N1L9; P35638: DDIT3; NbExp=2; IntAct=EBI-742695, EBI-742651;
CC Q8N1L9; O75593: FOXH1; NbExp=3; IntAct=EBI-742695, EBI-1759806;
CC Q8N1L9; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-742695, EBI-12018822;
CC Q8N1L9; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-742695, EBI-347538;
CC Q8N1L9; P49639: HOXA1; NbExp=3; IntAct=EBI-742695, EBI-740785;
CC Q8N1L9; P05412: JUN; NbExp=2; IntAct=EBI-742695, EBI-852823;
CC Q8N1L9; P17275: JUNB; NbExp=5; IntAct=EBI-742695, EBI-748062;
CC Q8N1L9; O76011: KRT34; NbExp=3; IntAct=EBI-742695, EBI-1047093;
CC Q8N1L9; Q9ULX9: MAFF; NbExp=2; IntAct=EBI-742695, EBI-721128;
CC Q8N1L9; Q13064: MKRN3; NbExp=3; IntAct=EBI-742695, EBI-2340269;
CC Q8N1L9; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-742695, EBI-710402;
CC Q8N1L9; O75360: PROP1; NbExp=3; IntAct=EBI-742695, EBI-9027467;
CC Q8N1L9; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-742695, EBI-11959123;
CC Q8N1L9; O95231: VENTX; NbExp=3; IntAct=EBI-742695, EBI-10191303;
CC Q8N1L9; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-742695, EBI-1051237;
CC Q8N1L9-1; P05412: JUN; NbExp=3; IntAct=EBI-15746052, EBI-852823;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N1L9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N1L9-2; Sequence=VSP_025752;
CC -!- INDUCTION: By type I interferon. Down-regulated in most hepatocellular
CC carcinoma tumorous tissues (at protein level).
CC {ECO:0000269|PubMed:19074269, ECO:0000269|PubMed:20473897}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; HM134154; ADJ55304.1; -; mRNA.
DR EMBL; AK092453; BAC03894.2; -; mRNA.
DR EMBL; AK092761; BAC03968.2; -; mRNA.
DR EMBL; AK096702; BAC04846.1; -; mRNA.
DR EMBL; CH471076; EAW74330.1; -; Genomic_DNA.
DR EMBL; BC012330; AAH12330.1; -; mRNA.
DR CCDS; CCDS73317.1; -. [Q8N1L9-2]
DR CCDS; CCDS8087.1; -. [Q8N1L9-1]
DR RefSeq; NP_001287736.1; NM_001300807.1.
DR RefSeq; NP_001287737.1; NM_001300808.1. [Q8N1L9-2]
DR RefSeq; NP_612465.3; NM_138456.3. [Q8N1L9-1]
DR AlphaFoldDB; Q8N1L9; -.
DR SMR; Q8N1L9; -.
DR BioGRID; 125470; 29.
DR ComplexPortal; CPX-6523; bZIP transcription factor complex, ATF4-BATF2.
DR ComplexPortal; CPX-7061; bZIP transcription factor complex, BATF2-JUNB.
DR ComplexPortal; CPX-7063; bZIP transcription factor complex, BATF2-JUN.
DR ComplexPortal; CPX-7064; bZIP transcription factor complex, BATF2-DDIT3.
DR ComplexPortal; CPX-7065; bZIP transcription factor complex, BATF2-CEBPA.
DR ComplexPortal; CPX-7066; bZIP transcription factor complex, BATF2-CEBPG.
DR ComplexPortal; CPX-7067; bZIP transcription factor complex, BATF2-CEBPE.
DR ComplexPortal; CPX-7068; bZIP transcription factor complex, BATF2-DBP.
DR ComplexPortal; CPX-7081; bZIP transcription factor complex, BATF2-HLF.
DR ComplexPortal; CPX-7085; bZIP transcription factor complex, BATF2-MAFF.
DR DIP; DIP-48662N; -.
DR IntAct; Q8N1L9; 28.
DR STRING; 9606.ENSP00000301887; -.
DR GlyGen; Q8N1L9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N1L9; -.
DR PhosphoSitePlus; Q8N1L9; -.
DR BioMuta; BATF2; -.
DR DMDM; 74750901; -.
DR MassIVE; Q8N1L9; -.
DR PaxDb; Q8N1L9; -.
DR PeptideAtlas; Q8N1L9; -.
DR PRIDE; Q8N1L9; -.
DR Antibodypedia; 29580; 197 antibodies from 28 providers.
DR DNASU; 116071; -.
DR Ensembl; ENST00000301887.9; ENSP00000301887.4; ENSG00000168062.10. [Q8N1L9-1]
DR Ensembl; ENST00000435842.2; ENSP00000398911.2; ENSG00000168062.10. [Q8N1L9-2]
DR GeneID; 116071; -.
DR KEGG; hsa:116071; -.
DR MANE-Select; ENST00000301887.9; ENSP00000301887.4; NM_138456.4; NP_612465.3.
DR UCSC; uc001oce.1; human. [Q8N1L9-1]
DR CTD; 116071; -.
DR DisGeNET; 116071; -.
DR GeneCards; BATF2; -.
DR HGNC; HGNC:25163; BATF2.
DR HPA; ENSG00000168062; Low tissue specificity.
DR MIM; 614983; gene.
DR neXtProt; NX_Q8N1L9; -.
DR OpenTargets; ENSG00000168062; -.
DR PharmGKB; PA143485315; -.
DR VEuPathDB; HostDB:ENSG00000168062; -.
DR eggNOG; KOG1414; Eukaryota.
DR GeneTree; ENSGT00940000162373; -.
DR HOGENOM; CLU_088611_0_0_1; -.
DR InParanoid; Q8N1L9; -.
DR OMA; HGCQEQP; -.
DR OrthoDB; 1269564at2759; -.
DR PhylomeDB; Q8N1L9; -.
DR TreeFam; TF332340; -.
DR PathwayCommons; Q8N1L9; -.
DR SignaLink; Q8N1L9; -.
DR BioGRID-ORCS; 116071; 12 hits in 1101 CRISPR screens.
DR ChiTaRS; BATF2; human.
DR GenomeRNAi; 116071; -.
DR Pharos; Q8N1L9; Tbio.
DR PRO; PR:Q8N1L9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N1L9; protein.
DR Bgee; ENSG00000168062; Expressed in pancreatic ductal cell and 123 other tissues.
DR ExpressionAtlas; Q8N1L9; baseline and differential.
DR Genevisible; Q8N1L9; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR GO; GO:0140467; P:integrated stress response signaling; IC:ComplexPortal.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR029857; BATF2.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR PANTHER; PTHR23351:SF11; PTHR23351:SF11; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..274
FT /note="Basic leucine zipper transcriptional factor ATF-like
FT 2"
FT /id="PRO_0000288681"
FT DOMAIN 17..80
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20..41
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 45..66
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 128..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025752"
FT VARIANT 6
FT /note="G -> S (in dbSNP:rs12419103)"
FT /id="VAR_048443"
SQ SEQUENCE 274 AA; 29398 MW; CC4BDAA61A681B14 CRC64;
MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR
KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ
LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH
TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH
KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF
