BATF2_MOUSE
ID BATF2_MOUSE Reviewed; 277 AA.
AC Q8R1H8; Q3TAI2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Basic leucine zipper transcriptional factor ATF-like 2;
DE Short=B-ATF-2;
GN Name=Batf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=22992524; DOI=10.1038/nature11531;
RA Tussiwand R., Lee W.L., Murphy T.L., Mashayekhi M., Kc W., Albring J.C.,
RA Satpathy A.T., Rotondo J.A., Edelson B.T., Kretzer N.M., Wu X., Weiss L.A.,
RA Glasmacher E., Li P., Liao W., Behnke M., Lam S.S., Aurthur C.T.,
RA Leonard W.J., Singh H., Stallings C.L., Sibley L.D., Schreiber R.D.,
RA Murphy K.M.;
RT "Compensatory dendritic cell development mediated by BATF-IRF
RT interactions.";
RL Nature 490:502-507(2012).
CC -!- FUNCTION: AP-1 family transcription factor that controls the
CC differentiation of lineage-specific cells in the immune system.
CC Selectively suppresses CCN1 transcription and hence blocks the
CC downstream cell proliferation signals produced by CCN1 and inhibits
CC CCN1-induced anchorage-independent growth and invasion in several
CC cancer types. Possibly acts by interfering with AP-1 binding to CCN1
CC promoter (By similarity). Following infection, participates in the
CC differentiation of CD8(+) thymic conventional dendritic cells in the
CC immune system. Acts via the formation of a heterodimer with JUN family
CC proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and
CC regulates expression of target genes. {ECO:0000250,
CC ECO:0000269|PubMed:22992524}.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with JUN family proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R1H8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R1H8-2; Sequence=VSP_025753;
CC -!- INDUCTION: By cytokines in response to infection. By IFN-gamma.
CC {ECO:0000269|PubMed:22992524}.
CC -!- DISRUPTION PHENOTYPE: Mice display normal development of natural killer
CC (NK), T- and B-cells, plasmacytoid dendritic cells (pDCs), neutrophils,
CC resting CD8-alpha(+) classical dendritic cells (cDCs), and peritoneal,
CC liver and lung macrophages. However, they show significantly decreased
CC survival after infection by T.gondii. Notably, mice show significantly
CC decreased numbers of lung-resident CD103(+)CD11b(-) dendritic cells and
CC CD103(+)CD11b(-) macrophages after infection.
CC {ECO:0000269|PubMed:22992524}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; AK150133; BAE29330.1; -; mRNA.
DR EMBL; AK171828; BAE42686.1; -; mRNA.
DR EMBL; BC024521; AAH24521.1; -; mRNA.
DR CCDS; CCDS29497.1; -. [Q8R1H8-1]
DR CCDS; CCDS89321.1; -. [Q8R1H8-2]
DR RefSeq; NP_083243.1; NM_028967.1. [Q8R1H8-1]
DR RefSeq; XP_006531914.1; XM_006531851.2.
DR AlphaFoldDB; Q8R1H8; -.
DR SMR; Q8R1H8; -.
DR STRING; 10090.ENSMUSP00000045744; -.
DR iPTMnet; Q8R1H8; -.
DR PhosphoSitePlus; Q8R1H8; -.
DR PaxDb; Q8R1H8; -.
DR PRIDE; Q8R1H8; -.
DR ProteomicsDB; 273650; -. [Q8R1H8-1]
DR ProteomicsDB; 273651; -. [Q8R1H8-2]
DR Antibodypedia; 29580; 197 antibodies from 28 providers.
DR DNASU; 74481; -.
DR Ensembl; ENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699. [Q8R1H8-1]
DR Ensembl; ENSMUST00000237511; ENSMUSP00000158113; ENSMUSG00000039699. [Q8R1H8-2]
DR GeneID; 74481; -.
DR KEGG; mmu:74481; -.
DR UCSC; uc008ghp.1; mouse. [Q8R1H8-2]
DR UCSC; uc008ghq.1; mouse. [Q8R1H8-1]
DR CTD; 116071; -.
DR MGI; MGI:1921731; Batf2.
DR VEuPathDB; HostDB:ENSMUSG00000039699; -.
DR eggNOG; KOG1414; Eukaryota.
DR GeneTree; ENSGT00940000162373; -.
DR HOGENOM; CLU_088611_0_0_1; -.
DR InParanoid; Q8R1H8; -.
DR OMA; HGCQEQP; -.
DR OrthoDB; 1269564at2759; -.
DR PhylomeDB; Q8R1H8; -.
DR TreeFam; TF332340; -.
DR BioGRID-ORCS; 74481; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Batf2; mouse.
DR PRO; PR:Q8R1H8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8R1H8; protein.
DR Bgee; ENSMUSG00000039699; Expressed in small intestine Peyer's patch and 45 other tissues.
DR Genevisible; Q8R1H8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042832; P:defense response to protozoan; IMP:UniProtKB.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR029857; BATF2.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR PANTHER; PTHR23351:SF11; PTHR23351:SF11; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..277
FT /note="Basic leucine zipper transcriptional factor ATF-like
FT 2"
FT /id="PRO_0000288682"
FT DOMAIN 18..81
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 15..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20..42
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 46..67
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 126..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 48
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025753"
SQ SEQUENCE 277 AA; 29703 MW; A7FA4E1A0A8249C9 CRC64;
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQQH ESLEKQNHAL
RKEIQALQTE LAGWGRTLHL HERLCRVDCD PCPVLLPSGC PIQAKQPSGQ PAPLGYNGCQ
EQLGLFQTPG SSPRAQHLSP GPCSHESPGL LPSLLPSLAF DPLMVRTPLA QLSPSPVLSA
SSPSGSSLLG SFSKLDPLIP SPQDQLAPPQ PLRQEQPTSG RLASSDSPAA LGPECSQNRE
HLPALPGSST HWQKSSVAPS PQALMAFPLL SSAKVHF
