ID   BATF_XENLA              Reviewed;         115 AA.
AC   A1L2X1;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Basic leucine zipper transcriptional factor ATF-like;
DE   AltName: Full=B-cell-activating transcription factor;
DE            Short=B-ATF;
GN   Name=batf;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: AP-1 family transcription factor that controls the
CC       differentiation of lineage-specific cells in the immune system:
CC       specifically mediates the differentiation of T-helper 17 cells (Th17),
CC       follicular T-helper cells (TfH), CD8(+) dendritic cells and class-
CC       switch recombination (CSR) in B-cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC       Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but
CC       shows increased nuclear translocation after activation of T-cells.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; BC129757; AAI29758.1; -; mRNA.
DR   RefSeq; NP_001091208.1; NM_001097739.1.
DR   AlphaFoldDB; A1L2X1; -.
DR   SMR; A1L2X1; -.
DR   DNASU; 100036977; -.
DR   GeneID; 100036977; -.
DR   KEGG; xla:100036977; -.
DR   CTD; 100036977; -.
DR   Xenbase; XB-GENE-6255842; batf.L.
DR   OMA; CTGLTPQ; -.
DR   OrthoDB; 1509232at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 100036977; Expressed in spleen and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
DR   GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0072539; P:T-helper 17 cell differentiation; ISS:UniProtKB.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; ISS:UniProtKB.
DR   GO; GO:0045064; P:T-helper 2 cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR000837; AP-1.
DR   InterPro; IPR029820; BATF.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   PANTHER; PTHR23351; PTHR23351; 1.
DR   PANTHER; PTHR23351:SF14; PTHR23351:SF14; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   PRINTS; PR00042; LEUZIPPRFOS.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..115
FT                   /note="Basic leucine zipper transcriptional factor ATF-
FT                   like"
FT                   /id="PRO_0000420466"
FT   DOMAIN          27..90
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..51
FT                   /note="Basic motif"
FT   REGION          55..83
FT                   /note="Leucine-zipper"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  13067 MW;  3228AFA44A0F9A20 CRC64;
     MQQESDRNEQ GYSSSPPSSN KQDSSDDTKK NHRREKNRIA AQKSRQRQTE KADSLHIESE
     NLERLNSALR GEISGLREEL KYLTCVLSTH QPVCVLGPTK PQAILPHVGS TRYQH