BATF_XENTR
ID BATF_XENTR Reviewed; 115 AA.
AC F7EMX9;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Basic leucine zipper transcriptional factor ATF-like;
DE AltName: Full=B-cell-activating transcription factor;
DE Short=B-ATF;
GN Name=batf;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
CC -!- FUNCTION: AP-1 family transcription factor that controls the
CC differentiation of lineage-specific cells in the immune system:
CC specifically mediates the differentiation of T-helper 17 cells (Th17),
CC follicular T-helper cells (TfH), CD8(+) dendritic cells and class-
CC switch recombination (CSR) in B-cells. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but
CC shows increased nuclear translocation after activation of T-cells.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; AAMC01082899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002938637.1; XM_002938591.4.
DR AlphaFoldDB; F7EMX9; -.
DR SMR; F7EMX9; -.
DR STRING; 8364.ENSXETP00000028965; -.
DR PaxDb; F7EMX9; -.
DR GeneID; 100492340; -.
DR KEGG; xtr:100492340; -.
DR CTD; 10538; -.
DR Xenbase; XB-GENE-6258076; batf.
DR eggNOG; KOG1414; Eukaryota.
DR HOGENOM; CLU_088612_4_0_1; -.
DR InParanoid; F7EMX9; -.
DR OMA; APQTTHD; -.
DR OrthoDB; 1509232at2759; -.
DR PhylomeDB; F7EMX9; -.
DR TreeFam; TF332340; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISS:UniProtKB.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
DR GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072539; P:T-helper 17 cell differentiation; ISS:UniProtKB.
DR GO; GO:0072540; P:T-helper 17 cell lineage commitment; ISS:UniProtKB.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; ISS:UniProtKB.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR029820; BATF.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR PANTHER; PTHR23351:SF14; PTHR23351:SF14; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00042; LEUZIPPRFOS.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..115
FT /note="Basic leucine zipper transcriptional factor ATF-
FT like"
FT /id="PRO_0000420467"
FT DOMAIN 27..90
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 29..51
FT /note="Basic motif"
FT REGION 55..83
FT /note="Leucine-zipper"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 115 AA; 13083 MW; 6E7439852FE4618B CRC64;
MQQEPDRNEQ GYCSSPPSSN KQDSSDDTKK IQRREKNRIA AQKSRQRQTQ KADSLHIESE
NLERLNSALR GEISGLREEL KYLTCVLSTH QPVCVLGPTK PQAILPHVGS TRYQH
