ID   BAT_HALSA               Reviewed;         674 AA.
AC   Q9HPU8; P13260;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Bacterioopsin transcriptional activator;
GN   Name=bat; OrderedLocusNames=VNG_1464G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3170488; DOI=10.1128/jb.170.10.4903-4909.1988;
RA   Leong D., Pfeifer F., Boyer H., Betlach M.;
RT   "Characterization of a second gene involved in bacterio-opsin gene
RT   expression in a halophilic archaebacterium.";
RL   J. Bacteriol. 170:4903-4909(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   FUNCTION.
RX   PubMed=2459111; DOI=10.1128/jb.170.10.4910-4915.1988;
RA   Leong D., Boyer H., Betlach M.;
RT   "Transcription of genes involved in bacterio-opsin gene expression in
RT   mutants of a halophilic archaebacterium.";
RL   J. Bacteriol. 170:4910-4915(1988).
RN   [4]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RX   PubMed=8202511; DOI=10.1073/pnas.91.12.5475;
RA   Gropp F., Betlach M.C.;
RT   "The bat gene of Halobacterium halobium encodes a trans-acting oxygen
RT   inducibility factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:5475-5479(1994).
CC   -!- FUNCTION: Involved in activating bop (bacterioopsin) and brp gene
CC       expression at low-oxygen tension, which naturally occurs in stationary
CC       phase. {ECO:0000269|PubMed:2459111, ECO:0000269|PubMed:8202511}.
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DR   EMBL; M23247; AAA72719.1; -; Genomic_DNA.
DR   EMBL; AE004437; AAG19769.1; -; Genomic_DNA.
DR   PIR; A43650; A43650.
DR   PIR; E84300; E84300.
DR   RefSeq; WP_010903066.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPU8; -.
DR   SMR; Q9HPU8; -.
DR   STRING; 64091.VNG_1464G; -.
DR   PaxDb; Q9HPU8; -.
DR   PRIDE; Q9HPU8; -.
DR   EnsemblBacteria; AAG19769; AAG19769; VNG_1464G.
DR   GeneID; 5953588; -.
DR   KEGG; hal:VNG_1464G; -.
DR   PATRIC; fig|64091.14.peg.1119; -.
DR   HOGENOM; CLU_010057_3_0_2; -.
DR   OMA; KLCRAFF; -.
DR   OrthoDB; 16486at2157; -.
DR   PhylomeDB; Q9HPU8; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR031803; BAT_GAF/HTH-assoc.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR007050; HTH_bacterioopsin.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF15915; BAT; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF04967; HTH_10; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Activator; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..674
FT                   /note="Bacterioopsin transcriptional activator"
FT                   /id="PRO_0000064835"
FT   DOMAIN          19..131
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          156..229
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          230..284
FT                   /note="PAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT   DOMAIN          285..454
FT                   /note="GAF"
FT   DOMAIN          617..668
FT                   /note="HTH bat-type"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        217..221
FT                   /note="DRVAE -> EPRGG (in Ref. 1; AAA72719)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   674 AA;  73396 MW;  645D776F3E66D778 CRC64;
     MTSVQNTESE TAAGATTIGV LFAGSDPETG PAACDLDEDG RFDVTQIRDF VAARDRVDDP
     DIDCVVAVHE PDGFDGVAFL EAVRQTHAEF PVVVVPTAVD EDVARRAVDA DATGLVPAVS
     EDATAAIADR IEQSAPAHSE DTETRMPISD LTVESERRLK EQALDEAPIG ITISDATDPE
     EPIIYINDSF EDITGYSPDE VVGANHRFLQ GPKTNEDRVA EFWTAITEDH DTQVVLRNYR
     RDGSLFWNQV DISPIYDEDG TVSHYVGFQM DVSERMAAQQ ELQGERQSLD RLLDRVNGLM
     NDVTSALVRA ADREEIETRI TDRIGTGGEY AGAWFGRYDA TEDTITVAEA AGDCEGCDGD
     VFDLASAGEA VALLQDVVEQ REALVSTDAD GVSGTADGDA CVLVPVTYRS TTYGVLAVST
     AEHRIDDREQ VLLRSLGRTT GASINDALTR RTIATDTVLN IGVELSDTAL FLVELAGATD
     TTFEQEATIA DSQTQGVLML VTTPHDDPQA VVDTALGYDA VQDAEVIVST DDESVVQFDL
     SSSPLVDVLS ECGSRVIRMH ADRTTLELDV RVGTEGAARR VLSTLRDKYA DVELVAYHED
     DPEQTPHGFR EELRNDLTDR QLTALQKAYV SGYFEWPRRA EGKQLAESMD IVPSTYHQHL
     QAAKQKLVGA FFEE