BAUD_PSEAE
ID BAUD_PSEAE Reviewed; 475 AA.
AC Q9I703;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Probable GABA permease;
DE AltName: Full=4-amino butyrate transport carrier;
DE AltName: Full=Gamma-aminobutyrate permease;
GN Name=bauD; Synonyms=gabP; OrderedLocusNames=PA0129;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21622750; DOI=10.1128/jb.05105-11;
RA Yao X., He W., Lu C.D.;
RT "Functional characterization of seven gamma-glutamylpolyamine synthetase
RT genes and the bauRABCD locus for polyamine and beta-alanine utilization in
RT Pseudomonas aeruginosa PAO1.";
RL J. Bacteriol. 193:3923-3930(2011).
CC -!- FUNCTION: Involved in the degradation of beta-alanine.
CC {ECO:0000269|PubMed:21622750}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Activated by BauR. {ECO:0000269|PubMed:21622750}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene grow normally on
CC putrescine, cadaverine, and GABA, but growth on beta-alanine is
CC completely abolished. {ECO:0000269|PubMed:21622750}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC {ECO:0000305}.
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DR EMBL; AE004091; AAG03519.1; -; Genomic_DNA.
DR PIR; B83631; B83631.
DR RefSeq; NP_248819.1; NC_002516.2.
DR RefSeq; WP_003083784.1; NZ_QZGE01000015.1.
DR AlphaFoldDB; Q9I703; -.
DR SMR; Q9I703; -.
DR STRING; 287.DR97_3086; -.
DR PaxDb; Q9I703; -.
DR EnsemblBacteria; AAG03519; AAG03519; PA0129.
DR GeneID; 880844; -.
DR KEGG; pae:PA0129; -.
DR PATRIC; fig|208964.12.peg.134; -.
DR PseudoCAP; PA0129; -.
DR HOGENOM; CLU_007946_9_3_6; -.
DR InParanoid; Q9I703; -.
DR OMA; WEGGVHL; -.
DR PhylomeDB; Q9I703; -.
DR BioCyc; PAER208964:G1FZ6-131-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015185; F:gamma-aminobutyric acid transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019483; P:beta-alanine biosynthetic process; IDA:PseudoCAP.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR InterPro; IPR011265; GABA_permease.
DR Pfam; PF00324; AA_permease; 1.
DR TIGRFAMs; TIGR01773; GABAperm; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..475
FT /note="Probable GABA permease"
FT /id="PRO_0000428973"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 475 AA; 51313 MW; C48E317173820A4E CRC64;
MSKVVLASQL PNKRNASLAP GLKQRHVTML SIAGVIGAGL FVGSGHAIAA AGPAALLAYL
IAGTLVVLVM RMLGEMAVAS PDTGSFSTYA DRSIGRWAGF TIGWLYWWFW VLVIPLEAIA
AAAILNAWFP AIDTWIFALA VTFLLTVTNL FSVARYGEFE FWFALLKVIA IIAFIVLGAV
AIVGGLPERE VSGLSSLMAS HGGFVPNGYG AVLGALLTTM FSFMGTEIVT IAAAESKDPA
KQITRATNSV IWRIGLFYLV SIFIVISIVP WNDPLLIQVG SYQRALELLD IPHAKLIVDL
VVLVAVASCL NSAIYTSSRM VFSLAKRGDA PSVLKLTNTA HVPRPAVLAS TAVGFLTTIV
NYFAPEKVFT FLLASSGAVA LLVYLVIAVA QLRMRKQLQA SGQPIEFRMW LYPWLTWAVI
LFIVAALSIM LIMPEHRHEV FATALLTIFT VCLGLLNARR KPRLGEDYAG KTARV
