ID   BAUR_PSEAE              Reviewed;         305 AA.
AC   Q9I6Z9;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=HTH-type transcriptional activator BauR;
GN   Name=bauR; OrderedLocusNames=PA0133;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=21622750; DOI=10.1128/jb.05105-11;
RA   Yao X., He W., Lu C.D.;
RT   "Functional characterization of seven gamma-glutamylpolyamine synthetase
RT   genes and the bauRABCD locus for polyamine and beta-alanine utilization in
RT   Pseudomonas aeruginosa PAO1.";
RL   J. Bacteriol. 193:3923-3930(2011).
CC   -!- FUNCTION: Involved in the degradation of beta-alanine. BauR activates
CC       the transcription of the bauABCD operon. {ECO:0000269|PubMed:21622750}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene grow normally on
CC       putrescine, cadaverine, and GABA, but growth on beta-alanine is
CC       completely abolished. {ECO:0000269|PubMed:21622750}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG03523.1; -; Genomic_DNA.
DR   PIR; G83628; G83628.
DR   RefSeq; NP_248823.1; NC_002516.2.
DR   RefSeq; WP_003083805.1; NZ_QZGE01000015.1.
DR   AlphaFoldDB; Q9I6Z9; -.
DR   SMR; Q9I6Z9; -.
DR   STRING; 287.DR97_3090; -.
DR   PaxDb; Q9I6Z9; -.
DR   PRIDE; Q9I6Z9; -.
DR   EnsemblBacteria; AAG03523; AAG03523; PA0133.
DR   GeneID; 879432; -.
DR   KEGG; pae:PA0133; -.
DR   PATRIC; fig|208964.12.peg.138; -.
DR   PseudoCAP; PA0133; -.
DR   HOGENOM; CLU_039613_0_0_6; -.
DR   OMA; YRCRFVS; -.
DR   PhylomeDB; Q9I6Z9; -.
DR   BioCyc; PAER208964:G1FZ6-135-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009896; P:positive regulation of catabolic process; IMP:PseudoCAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..305
FT                   /note="HTH-type transcriptional activator BauR"
FT                   /id="PRO_0000428949"
FT   DOMAIN          15..72
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   305 AA;  33425 MW;  C50405AFF43FD1D2 CRC64;
     MAKSRNPSLG QVSDFDIRLL RIFKTIVECG SFSAAESTLG LSRSAISLHM GDLEKRLGMR
     LCQRGRAGFA LTDEGREVYR ATQTLLAALE GFRAEVNDLH QHLRGELNIG IINNLVTLPQ
     MRITHALSAL KGQGPQVRIN IGMTTPNEIE LGVLDGHLHV GVVPLISPLS GLEYLPLYDE
     HAQLYCSRGH ALFERADGDI AVDEVLAADA VAPSYRLPAE AQARHQELNN SASASDREGM
     AFLILTGNFI GYLPSHYAAD WVAAGMLRPL LPERFHYAIA LTIVTRKGRR PNLVLERFLE
     AVAVS